High expression of LMO2 in Hodgkin, Burkitt and germinal center diffuse large B cell lymphomas

Shams, Tahany M.

doi:10.1016/j.jnci.2011.10.006

Cited by 6 publications

(3 citation statements)

References 23 publications

(29 reference statements)

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“…An increasing number of studies have shown that lymphoma is considered the fourth most common tumor in Egypt; in particular, in adults, it represents 76.6% NHL and 23.4% HL [1].…”

Section: Discussionmentioning

confidence: 99%

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Clinical significance of LncRNA-MIAT as a non-invasive diagnostic marker of non-Hodgkin's lymphoma associated with occult hepatitis C virus infection

Rashad

Soliman

Obaya

et al. 2023

African Journal of Gastroenterology and Hepatology

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Aims: the current research aimed to investigate LncRNA-MIAT in patients with non-Hodgkin lymphoma (NHL) and to assess its correlation with clinicopathological features and treatment protocols of NHLs among Egyptian patients with Occult hepatitis C virus (HCV) infection (OCI).Patients & Methods: This study was conducted on 20 patients with NHL and 30 healthy subjects as the control group. All subjects were screened for HCV-RNA in both plasma and PBMCs. RT-PCR determined lncRNA-MIAT.Results: lncRNA-MIAT relative expression level was upregulated in NHL groups (2.73±0.86) compared to controls (1.06±0.07), P ˂0.001*. Among NHL, patients with OCI (3.2±0.63) had significantly higher levels of lncRNA-MIAT compared to HCV (2.6±1.08) and non-HCV (2.4±0.4), P ˂0.001*. Additionally, the relative expression levels of lncRNA-MIAT were significantly positively correlated with laboratory and clinicopathological features of NHL. Interestingly, concerning the treatment of DLBCL-NHL, there were significantly higher levels of lncRNA-MIAT in no treatment subgroup (n=10, 3.31±0.95) compared to successfully treated subgroups [CHOP (n=7, 1.58±0.34) and R-CHOP (n=3, 11.16±0.21), P ˂0.001* Conclusions: lncRNA-MIAT level was upregulated in NHL patients, particularly patients with OCI. Thus, circulatory lncRNA-MIAT may serve as a promising non-invasive diagnostic marker for NHL associated with OCI.

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“…An increasing number of studies have shown that lymphoma is considered the fourth most common tumor in Egypt; in particular, in adults, it represents 76.6% NHL and 23.4% HL [1].…”

Section: Discussionmentioning

confidence: 99%

“…Intriguingly, NHLs prevalence is about 4% of all diagnosed cancer and rank seventh in frequency among all cancers. Furthermore, many studies have shown that Original research lymphoma is considered the fourth most common tumor in Egypt, particularly in adults [1].…”

Section: Introductionmentioning

confidence: 99%

Clinical significance of LncRNA-MIAT as a non-invasive diagnostic marker of non-Hodgkin's lymphoma associated with occult hepatitis C virus infection

Rashad

Soliman

Obaya

et al. 2023

African Journal of Gastroenterology and Hepatology

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“…These cells can be found in the bone marrow, lymph nodes, spleen, thymus, and other organs. During lymphoma, lymphocytes alter and proliferate uncontrollably (1) .…”

Section: Introductionmentioning

confidence: 99%

Quality of Life for Family Caregivers of Patients with Lymph Nodes Cancer

El-Hamid¹,

Shafik²,

Saad³

2023

The Egyptian Journal of Hospital Medicine

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Background: Lymph nodes cancer is one of chronic diseases that require long-term care. Family caregivers as the closest one who lives with the cancer patient takes a significant role in providing care. This causes an important burden on caregivers and decreases their quality of life. Objective: The aim of the current study is to assess the quality of life for family caregivers of patients with lymph nodes cancer. Subjects and methods: A descriptive study was conducted in outpatient Cancer Clinic of General Fayoum Hospitals. Purposive sample was used and included 240 family caregivers. Tools of the study included: (1): Interviewing Questionnaire sheet that included two parts, Part I: Demographic characteristics, Part II: Knowledge Assessment Sheet, (2): Caregiver Quality of Life Index. Result: Up to 80% of the sample under investigation knew too little overall about lymph node cancer. There were statistically significant associations between the total knowledge scores of family caregiver of lymph node cancer patients and their age, educational attainment, and monthly income, as well as statistically significant associations between some socio-demographic data and their quality of life. Additionally, there was a highly statistically significant positive correlation between the total knowledge scores and the total quality of life. Conclusion: Majority of family caregivers with cancer patients had poor quality of life and unsatisfactory knowledge. Implementation of educational programe for family caregivers with cancer patients to enhance their quality of life is needed.

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Diagnostic Utility of the Germinal Center–associated Markers GCET1, HGAL, and LMO2 in Hematolymphoid Neoplasms

Menter

Gasser²,

Juškevičius³

et al. 2015

Applied Immunohistochemistry &Amp; Molecular Morphology

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Implementation of new phenotypic markers in routine diagnostics of hematolymphoid neoplasms is a challenging task with a plethora of potentially relevant proteins. We investigated 3 recently discovered proteins expressed in the germinal centers of lymph nodes (LMO2, GCET1, and HGAL) in a compilation of leukemia, lymphoma, and thymic tumor entities. Altogether, 1590 cases (1519 on tissue microarrays, 71 on conventional slides) were included. Expressions of LMO2, GCET1, and HGAL were investigated by immunohistochemistry, evaluated for their differential diagnostic relevance, and correlated with the clinical outcome of patients. In Hodgkin lymphoma (HL), the expression of LMO2, GCET1, and HGAL could be largely seen in tumor cells of nodular lymphocyte predominant HL (NLPHL) but only occasionally in classic HL. The majority of B-cell lymphoma cases was positive for LMO2 [except for Burkitt lymphoma (BL)] and HGAL with weaker to moderate staining intensity, compared with the intensely staining follicular lymphomas (FL). Except for FL (60% of cases) and diffuse large B-cell lymphomas (DLBCL, 36% of cases), all other B-cell lymphomas expressed little or no GCET1. In thymomas, the non-neoplastic immature T-cells were LMO2-negative, whereas the neoplastic lymphoblasts were LMO2-positive in more than half of the lymphoblastic lymphomas (LBL). Our findings provide new potential assistance in the differential diagnosis of FL to marginal zone lymphoma, classic HL to NLPHL and primary mediastinal B-cell lymphoma, DLBCL to BL, and thymoma to LBL. Finally, HGAL proved to be a prognostic marker for classic HL regarding the background population and in DLBCL regarding the tumor cells.

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High expression of LMO2 in Hodgkin, Burkitt and germinal center diffuse large B cell lymphomas

Abstract: LMO2 expression is a special feature of GC DLBCL which can be used as a diagnostic marker and therapeutic target. Further studies regarding its prognostic role in patients are recommended.

Cited by 6 publications

References 23 publications

Clinical significance of LncRNA-MIAT as a non-invasive diagnostic marker of non-Hodgkin's lymphoma associated with occult hepatitis C virus infection

Clinical significance of LncRNA-MIAT as a non-invasive diagnostic marker of non-Hodgkin's lymphoma associated with occult hepatitis C virus infection

Quality of Life for Family Caregivers of Patients with Lymph Nodes Cancer

Diagnostic Utility of the Germinal Center–associated Markers GCET1, HGAL, and LMO2 in Hematolymphoid Neoplasms

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