High encapsulation efficiency of poloxamer-based injectable thermoresponsive hydrogels of etoposide

Soni, Govind; Yadav, Khushwant S.

doi:10.3109/10837450.2013.819014

Cited by 52 publications

(33 citation statements)

References 25 publications

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“…Concerning ETO-loaded nanoparticles prepared in the last decade, only very high dimensioned pegylated liposomal ETO nanoparticles of 491 nm, characterized by a limited DL% of 10%, proved to have a very high entrapment efficiency of 99% [76]. In other cases, the ETO EE% was either very low (4-14%) [77] or, though high (75-84%) [78], were not as high as the EE% achieved in this study by using dendrimer 4. Only recently, Thiyagarajan et al [79], have prepared a series of polymeric nanoparticles containing ETO for targeting cancer cells that had a high DL% (62-90%) and in some cases very high EE% (49-94%).…”

Section: Estimation Of Eto Amount In Cpx 5 (Dl%) and Of Entrapment Efcontrasting

confidence: 72%

Polyester-Based Dendrimer Nanoparticles Combined with Etoposide Have an Improved Cytotoxic and Pro-Oxidant Effect on Human Neuroblastoma Cells

2020

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Etoposide (ETO) is a cytotoxic drug that exerts its effect by increasing reactive oxygen species (ROS) production. Although ETO is widely used, fast metabolism, poor solubility, systemic toxicity, and multi-drug resistance induction all limit its administration dosage and its therapeutic efficiency. In order to address these issues, a biodegradable dendrimer was prepared for entrapping and protecting ETO and for enhancing its solubility and effectiveness. The achieved dendrimer complex with ETO (CPX 5) showed the typical properties of a well-functioning delivery system, i.e., nanospherical morphology (70 nm), optimal Z-potential (−45 mV), good drug loading (37%), very satisfying entrapment efficiency (53%), and a remarkably improved solubility in biocompatible solvents. In regards to its cytotoxic activity, CPX 5 was tested on neuroblastoma (NB) cells with very promising results. In fact, the dendrimer scaffold and ETO are able to exert per se a cytotoxic and pro-oxidant activity on human NB cells. When CPX 5 is combined with ETO, it shows a synergistic action, slowly releasing the drug over time and significantly improving and protracting bioactivity. On the basis of these findings, the prepared ETO reservoir represents a novel biodegradable and promising device for the delivery of ETO into NB cells.

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Section: Estimation Of Eto Amount In Cpx 5 (Dl%) and Of Entrapment Efcontrasting

confidence: 72%

Polyester-Based Dendrimer Nanoparticles Combined with Etoposide Have an Improved Cytotoxic and Pro-Oxidant Effect on Human Neuroblastoma Cells

2020

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“…To overcome these disadvantages, we must take special measures to prolong drug release and better encapsulate hydrophobic drugs. 86,92,96,98 …”

Section: Miscellaneous Temperature-responsive Nanocarriersmentioning

confidence: 99%

Temperature-Responsive Smart Nanocarriers for Delivery Of Therapeutic Agents: Applications and Recent Advances

Karimi

Zangabad

Ghasemi

et al. 2016

ACS Appl. Mater. Interfaces

317

212

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Smart drug delivery systems (DDSs) have attracted the attention of many scientists, as carriers that can be stimulated by changes in environmental parameters such as temperature, pH, light, electromagnetic fields, mechanical forces, etc. These smart nanocarriers can release their cargo on demand when their target is reached and the stimulus is applied. Using the techniques of nanotechnology, these nanocarriers can be tailored to be target-specific, and exhibit delayed or controlled release of drugs. Temperature-responsive nanocarriers are one of most important groups of smart nanoparticles (NPs) that have been investigated during the past decades. Temperature can either act as an external stimulus when heat is applied from the outside, or can be internal when pathological lesions have a naturally elevated termperature. A low critical solution temperature (LCST) is a special feature of some polymeric materials, and most of the temperature-responsive nanocarriers have been designed based on this feature. In this review, we attempt to summarize recent efforts to prepare innovative temperature-responsive nanocarriers and discuss their novel applications.

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“…The sol–gel transition process, commonly determined by tube inversion method, was investigated using glass slides in this study . This in‐vitro technique was used as a proof of concept to observe the transition property of poloxamer‐based formulation on a glass slide, maintained at oromucosal temperature (37 °C).…”

Section: Methodsmentioning

confidence: 99%

“…The sol-gel transition process, commonly determined by tube inversion method, was investigated using glass slides in this study. [20] This in-vitro technique was used as a proof of concept to observe the transition property of poloxamer-based formulation on a glass slide, maintained at oromucosal temperature (37°C). Piroxicam 0.05% w/w concentration of poloxamer-based formulation was mixed with pH 7.2 artificial saliva solution in the ratio of 0.2 : 0.1, and the same was followed for the non-poloxamer-based formulation.…”

Section: Evaluation Of Sol-gel Transition Property Of the Poloxamer-bmentioning

confidence: 99%

Formulation and evaluation of sublingual delivery of piroxicam using thermosensitive polymer with an inverted Franz diffusion cell

Sivaraman

Banga

2015

Journal of Pharmacy and Pharmacology

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High encapsulation efficiency of poloxamer-based injectable thermoresponsive hydrogels of etoposide

Abstract: Such injectable thermosensitive hydrogel of etoposide could be effectively used for continuous release of drug to the tumor and surrounding tissues.

Cited by 52 publications

References 25 publications

Polyester-Based Dendrimer Nanoparticles Combined with Etoposide Have an Improved Cytotoxic and Pro-Oxidant Effect on Human Neuroblastoma Cells

Polyester-Based Dendrimer Nanoparticles Combined with Etoposide Have an Improved Cytotoxic and Pro-Oxidant Effect on Human Neuroblastoma Cells

Temperature-Responsive Smart Nanocarriers for Delivery Of Therapeutic Agents: Applications and Recent Advances

Formulation and evaluation of sublingual delivery of piroxicam using thermosensitive polymer with an inverted Franz diffusion cell

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