“…Electrochemiluminescence (ECL) involves the electrochemically triggered energy-relaxation phenomenon in which the luminophore can utilize electron-transfer to achieve excited states for emitting light. − ECL has been extensively identified to be a persuasive analytical technique with merits of intrinsically low background, high sensitivity, broad detection range, and admirable controllability. , Recently, Au nanoclusters (AuNCs) as one of the most burgeoning electrochemiluminophores have obtained remarkable attention owing to their distinctive chemical, electrical, and optical characteristics. − In particular, l -methionine ( l -Met) stabilized AuNCs with admirable biocompatibility not only act as a near-infrared (NIR) signal label with improved susceptibility and circumambient adaptability, but also function as a linker for the decoration of immunizing molecules via sufficient functional groups supplied by l -Met. , However, AuNCs usually undergo poor ECL efficiency due to the depressed charges transfer efficiency in the electrogenerated procedure and plentiful nonradiative transition of excited species in the energy relaxed process. − More recently, the biocompatible AuNCs with property of aggregation induced emission (AIE) have been exploited to promote the ECL efficiency via inhibiting the nonradiative transition. , However, the insufficient charge-transfer mechanism during electrochemical redox of AuNCs has not been systematically solved and still results in the inferior NIR ECL efficiency, which becomes primary factor that affects the widespread application and sensitive bioassay. Then, it is anticipated to implement considerable endeavors to explore appropriately supplementary methods for enhancing the charge transfer and facilitating the NIR ECL efficiency of AuNCs.…”