Identifying Highly Photoelectrochemical Active Sites of Two Au<sub>21</sub> Nanocluster Isomers toward Bright Near-Infrared Electrochemiluminescence

Hesari, Mahdi; Ding, Zhifeng

doi:10.1021/jacs.1c08877

Cited by 58 publications

(55 citation statements)

References 83 publications

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“…The 45 nm difference between the onset peak wavelength and the maximum intensity wavelength is probably due to the formation of different excited states of Cu NCs in the process of potential negative scanning as the valence state of the obtained Cu NCs is between 0 and +1 as demonstrated from XPS. Although it is hard to decide the exact content of Cu(0) and Cu(I) in the obtained Cu NCs, a series of similar valence-state-dependent ECL emission wavelength investigations on gold nanoclusters have been concluded by the Ding group. ,− Upon sweeping the potential further negative and backwards, the ECL intensity decreased owing to the depletion of the Cu NCs –• and SO 4 –• species and led to the ECL devolution (Figure C).…”

Section: Experimental Sectionmentioning

confidence: 72%

Near-Infrared Electrogenerated Chemiluminescence from Simple Copper Nanoclusters for Sensitive Alpha-Fetoprotein Sensing

Zhang

Cong

et al. 2022

Anal. Chem.

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Exploiting low cost, water-soluble, and near-infrared (NIR) emissive electrochemiluminophores (ECLphores) is significantly important for biological applications. In this study, bright and NIR electrogenerated chemiluminescence (ECL) emissive copper nanoclusters (Cu NCs) were synthesized through a facile one-pot wet chemical reduction method. ECL properties of obtained Cu NCs were examined in the presence of potassium persulfate, resulting in maximum intensity at 735 nm, at least 135 nm red-shifted with respect to all other Cu NCs. Electrochemistry, photoluminescence (PL), and spooling ECL spectroscopies were used to track NIR ECL emission of Cu NCs ascribed to the monomeric excited states. Due to the abundant binding sites of bovine serum albumin (BSA) to anchor target biomolecules, a sandwich-type ECL immunosensor was thus fabricated using such BSA-templated Cu NCs as tags and alpha fetoprotein antigen (AFP) as a model protein for the first time. Without assisting any signal amplification strategies, the proposed NIR ECL biosensor exhibited a wide linear range (1−400 ng mL −1 ) and low detection limit (0.02 ng mL −1 ) as well as superior selectivity and reproducibility and was successfully applied in real human serum sample determination. This work sets the stage for the development of novel non-noble metal nanoclusters for large-scale and emerging nanotechnology applications.

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Section: Experimental Sectionmentioning

confidence: 72%

Near-Infrared Electrogenerated Chemiluminescence from Simple Copper Nanoclusters for Sensitive Alpha-Fetoprotein Sensing

Zhang

Cong

et al. 2022

Anal. Chem.

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“…In recent years, electrochemiluminescence (ECL) as another optical analysis tool has attracted great interests, especially in bioanalysis. − For ECL to occur, photons-releasing excited states are produced in the vicinity of the electrode through electron transfer reactions of electrogenerated radical species. − There are two general routes giving ECL. The first is the annihilation pathway, where the radical cation and radical anion generated by reduction and oxidation of electrochemiluminophore (ECLphore) at the electrode, respectively, are annihilated to produce excited states, giving off light .…”

Section: Introductionmentioning

confidence: 99%

Polymer Carbon Nanodots: A Novel Electrochemiluminophore for Dual Mode Detection of Ferric Ions

et al. 2022

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The development of simple and effective dual-mode analytical methods plays crucial regulatory roles in the discrimination of relevant target species, because of their built-in cross reference correction and high accuracy. In this work, a novel polymer carbon nanodots (PCNDs) prepared from a facile one-pot hydrothermal procedure using readily available L-tryptophan and L-phenylalanine as precursors, showed excellent aqueous solubility and blue fluorescence property with a high quantum yield of 29%. Moreover, the PCNDs was demonstrated to be a robust luminophore with electrochemiluminescence (ECL) efficiency of 43% was achieved by using K 2 S 2 O 8 as a coreactant. The spooling ECL spectroscopy was employed to take insight into excited states responsible for the potential-dependent ECL emissions. Most importantly, when introduced into construction of the fluorescence and ECL dual mode sensing platform, for the first time, the PCNDs displayed prominent performance for the detection of ferric ions (Fe 3+ ). The ferric ions could be quantified ranging from micromolar to millimolar with a detection limit of 0.22 and 5.3 μM, respectively. Such a dual-functional sensing platform also exhibits excellent selectivity, reproducibility and stability. Results from this work indicate that PCNDs showing great promise as a bright luminophore for the fabrication of low-cost, high-performance dual-signal readout platforms for ferric ions determination.

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“…As a kind of promising ECL luminophore, − Au nanoclusters (AuNCs) have attracted extensive attention for their ultra-small size, unique optical properties, excellent stability, and high biocompatibility. − A series of AuNCs have been developed, most of them are modified or synthesized with proteins or amino acids as capping agents, such as bovine serum albumin, , methionine, and glutathione, or nonlinear sulfhydryl chains containing more functional groups, such as captopril, N-acetyl- l -cysteine, , and lipoic acid . Due to the interaction of various functional groups and/or branched chains of capping agents at the surface of these AuNCs, − it is still difficult to discriminate the function of the carbon skeleton on the ECL of AuNCs.…”

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confidence: 99%

Surface Defect-Involved and Single-Color Electrochemiluminescence of Gold Nanoclusters for Immunoassay

Gao

Wang

et al. 2022

Anal. Chem.

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Single-color electrochemiluminescence (ECL) of nanoparticles is normally achieved in a bandgap engineered route via passivating the nanoparticle surface. Herein, when linear mercaptoalkanoic acids are employed as the thiolcapping agent of unary Au nanoclusters (NCs), a single-stabilizer-capped strategy is proposed to achieve surface defect-involved and single-color ECL from the AuNCs with hydrazine (N 2 H 4 ) as the coreactant. The carbon skeleton of the linear mercaptoalkanoic acids exhibits important effects on the ECL of the AuNCs, and efficient oxidative−reductive ECL is achieved with 8-mercaptooctanoic acid (MOA), 11-mercaptoundecanoic acid (MUA), and 12-mercaptododecanoic acid (MDA) capped AuNCs, respectively. The ECL of these AuNCs not only exhibits similar ECL intensity−potential profiles with the same maximum emission potential of ∼1.20 V (vs Ag/AgCl), but also demonstrates almost identical spectral ECL profiles of the same maximum emission wavelength around 713 nm as well as the same fwhm of 64 nm. The ECL of AuNCs/N 2 H 4 is obviously red-shifted to the photoluminescence of AuNCs, which not only provides unambiguous evidence that bandgap-engineered ECL of these AuNCs is quenched but also manifests that the capping agent of linear mercaptoalkanoic acid is promising for the achievement of surface defect-involved and single-color ECL from AuNCs. The MUA capped AuNCs can be utilized as an ECL tag for a sensitive and selective immunoassay, which exhibits a broad linear range from 0.5 mU/mL to 1 U/mL with a low limit of detection of 0.1 mU/mL (S/N = 3) with CA125 as the model analyte. This work provides a promising alternative to the traditional surface-passivating strategy for the achievement of single-color ECL from nanoparticle luminophores.

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Identifying Highly Photoelectrochemical Active Sites of Two Au₂₁ Nanocluster Isomers toward Bright Near-Infrared Electrochemiluminescence

Cited by 58 publications

References 83 publications

Near-Infrared Electrogenerated Chemiluminescence from Simple Copper Nanoclusters for Sensitive Alpha-Fetoprotein Sensing

Near-Infrared Electrogenerated Chemiluminescence from Simple Copper Nanoclusters for Sensitive Alpha-Fetoprotein Sensing

Polymer Carbon Nanodots: A Novel Electrochemiluminophore for Dual Mode Detection of Ferric Ions

Surface Defect-Involved and Single-Color Electrochemiluminescence of Gold Nanoclusters for Immunoassay

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Identifying Highly Photoelectrochemical Active Sites of Two Au21 Nanocluster Isomers toward Bright Near-Infrared Electrochemiluminescence

Cited by 58 publications

References 83 publications

Near-Infrared Electrogenerated Chemiluminescence from Simple Copper Nanoclusters for Sensitive Alpha-Fetoprotein Sensing

Near-Infrared Electrogenerated Chemiluminescence from Simple Copper Nanoclusters for Sensitive Alpha-Fetoprotein Sensing

Polymer Carbon Nanodots: A Novel Electrochemiluminophore for Dual Mode Detection of Ferric Ions

Surface Defect-Involved and Single-Color Electrochemiluminescence of Gold Nanoclusters for Immunoassay

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Identifying Highly Photoelectrochemical Active Sites of Two Au₂₁ Nanocluster Isomers toward Bright Near-Infrared Electrochemiluminescence