High efficient electrical stimulation of hippocampal slices with vertically aligned carbon nanofiber microbrush array

Asis, Edward D. de; Nguyen-Vu, TD Barbara; Arumugam, Prabhu U.; Chen, Hua; Cassell, Alan M.; Andrews, Russell J.; Yang, Cary Y.; Li, Jun

doi:10.1007/s10544-009-9295-7

Cited by 46 publications

(27 citation statements)

References 24 publications

(43 reference statements)

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“…The stiffness of ECM which can be regulated by topography has also been related to neuronal differentiation [222] and neurite branching [223,224]. To mimic the anisotropic structures of brain cells, various synthetic nanostructures, mainly unidirectionally aligned fibers or grating patterns, have been fabricated by self-assembly [225–228], electrospinning [229–239], nanolithography [240–247], and other techniques [248,249]. On these artificial structures, unique and remarkable behaviors of nerve cells, such as neuronal differentiation, neurite outgrowth, alignment, and migration have been reported.…”

Section: Applications Of Nanotopography To Tissue Engineering and mentioning

confidence: 99%

Nanotopography-guided tissue engineering and regenerative medicine

Kim

Jiao

Hwang

et al. 2013

Advanced Drug Delivery Reviews

354

274

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Human tissues are intricate ensembles of multiple cell types embedded in complex and well-defined structures of the extracellular matrix (ECM). The organization of ECM is frequently hierarchical from nano to macro, with many proteins forming large scale structures with feature sizes up to several hundred microns. Inspired from these natural designs of ECM, nanotopography-guided approaches have been increasingly investigated for the last several decades. Results demonstrate that the nanotopography itself can activate tissue-specific function in vitro as well as promote tissue regeneration in vivo upon transplantation. In this review, we provide an extensive analysis of recent efforts to mimic functional nanostructures in vitro for improved tissue engineering and regeneration of injured and damaged tissues. We first characterize the role of various nanostructures in human tissues with respect to each tissue-specific function. Then, we describe various fabrication methods in terms of patterning principles and material characteristics. Finally, we summarize the applications of nanotopography to various tissues, which are classified into four types depending on their functions: protective, mechano-sensitive, electro-active, and shear stress-sensitive tissues. Some limitations and future challenges are briefly discussed at the end.

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Section: Applications Of Nanotopography To Tissue Engineering and mentioning

confidence: 99%

Nanotopography-guided tissue engineering and regenerative medicine

Kim

Jiao

Hwang

et al. 2013

Advanced Drug Delivery Reviews

354

274

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“…Extracellular stimulation and recording of both spontaneous and evoked activity in organotypic hippocampal slices was reported. de Asis and co-workers systematically compared PPy-coated VACNF MEA with tungsten wire electrodes, a planar platinum MEA, and an as-grown VACNF MEA for the recording of evoked signals from acute hippocampal slices (de Asis et al, 2009). Recently Su and co-workers synthesized CNTs on a cone-shaped silicon tip by catalytic thermal CVD.…”

Section: Carbon Nanotubes For Electrical Neuronal Interfacingmentioning

confidence: 99%

Carbon nanotube-based multi electrode arrays for neuronal interfacing: progress and prospects

Bareket¹,

Hanein²

2013

Front. Neural Circuits

129

120

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Carbon nanotube (CNT) coatings have been demonstrated over the past several years as a promising material for neuronal interfacing applications. In particular, in the realm of neuronal implants, CNTs have major advantages owing to their unique mechanical and electrical properties. Here we review recent investigations utilizing CNTs in neuro-interfacing applications. Cell adhesion, neuronal engineering and multi electrode recordings with CNTs are described. We also highlight prospective advances in this field, in particular, progress toward flexible, bio-compatible CNT-based technology.

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“…4.13g). However, VACNF MBAs were not able to evoke field potential waves without first being coated with PPy/KCl at 1.5 V for 120 s (Fig 4.13h) [266].…”

Section: Carbonmentioning

confidence: 99%

“…(e) CNT pillar electrode schematic of the cross section (not to scale); (f) a 50 μm diameter CNT pillar electrode [253]. SEM micrograph of VACNF electrode arrays at 45° perspective view: (g) asgrown VACNFs on electrodes and (h) a similar sample after PPy coating in solution and then dried in the air [266]. Another type of CNT pillar microarrays composed of 40 μm tall CNTs have been grown vertically on 50 μm × 50 μm electrode sites using a catalytic thermal chemical vapor deposition system have also been investigated [253] (Fig 4.13e, f).…”

Section: Carbonmentioning

confidence: 99%

See 1 more Smart Citation

Nanostructured Coatings for Improved Charge Delivery to Neurons

Kozai

Alba

Zhang

et al. 2014

Nanotechnology and Neuroscience: Nano-Electronic, Photonic and Mechanical Neuronal Interfacing

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This chapter explores the variability and limitations of traditional stimulation electrodes by first appreciating how electrical potential differences lead to efficacious activation of nearby neurons and examining the basic electrochemical mechanisms of charge transfer at an electrode/electrolyte interface. It then covers the advantages and current challenges of emerging micro-/nanostructured electrode materials for next-generation neural stimulation microelectrodes. Introduction to Electrical Stimulation of NeuronsStimulation electrodes have many clinical applications. The most common clinically approved stimulator is the artificial cardiac pacemaker, which is implanted into patients with a slow or arrhythmic heartbeat [1]. Artificial pacemakers use electrodes placed directly in contact with the heart muscles to regulate heart rate by delivering a timed series of electrical pulses. Another common stimulation device implanted into many adults and children is the cochlear implant [2]. Cochlear duct electrodes are designed as a series of stimulation contacts arranged along a flexible silicone carrier (Fig. 4.1a). These electrodes are placed into the cochlea where they directly electrically stimulate nerve cells, bypassing damaged hair cells that transduce acoustic vibrations into electrical impulses in the underlying nerve cells. (Fig. 4.1b). Electrical stimulation in these deep brain structures, such as the basal ganglia, has been used to treat symptoms of Parkinson's disease including tremor and bradykinesia, as well as other movement disorders such as dystonia [3][4][5]. In addition, DBS is being studied as a treatment for stroke, chronic pain, major depression, and chronic obesity [6-10]. For epilepsy and major depression, vagal nerve stimulation offers an alternative that does not require brain surgery [11,12]. In the extremities, functional electrical stimulation (FES) is used to deliver electrical current to activate nerves or muscles in disabled patients. FES has been applied to aid in standing, walking, and basic handgrips and for restoring bowel and bladder function [13][14][15]. Many other electrical stimulation applications exist, including the restoration of somatosensation and vision, the treatment of hypertension and gastroparesis, and the promotion of nerve regeneration [16][17][18][19].While these neurostimulation devices have demonstrated some success in bypassing, replacing, or treating damaged neural circuits, they are far from being able to reliably restore natural function in all patients. In order to understand the variability and limitations of traditional stimulation electrodes, we must first appreciate how electrical potential differences lead to efficacious activation of nearby neurons and examine the basic electrochemical mechanisms of charge transfer at an electrode/electrolyte interface. This chapter will first lay out our current knowledge of these areas and afterwards will cover the advantages and current challenges of emerging micro-/nanostructured electrode materials for ...

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High efficient electrical stimulation of hippocampal slices with vertically aligned carbon nanofiber microbrush array

Cited by 46 publications

References 24 publications

Nanotopography-guided tissue engineering and regenerative medicine

Nanotopography-guided tissue engineering and regenerative medicine

Carbon nanotube-based multi electrode arrays for neuronal interfacing: progress and prospects

Nanostructured Coatings for Improved Charge Delivery to Neurons

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