High Efficiency Fabrication of Chitosan Composite Nanofibers with Uniform Morphology via Centrifugal Spinning

Li, Zhen; Shunqi, Mei; Dong, Yajie; She, Fenghua; Kong, Lingxue

doi:10.3390/polym11101550

Cited by 53 publications

(40 citation statements)

References 61 publications

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“…The latter seems to be more important as the quantity of nanofibers increases with electrospinning time. This behavior is consistent with other works (Li et al 2015(Li et al , 2019Phan et al 2018;Szymańska-Chargot et al 2019).…”

Section: Mechanical Properties Of Sorbent Materialssupporting

confidence: 93%

Cellulose reinforced electrospun chitosan nanofibers bio-based composite sorbent for water treatment applications

et al. 2021

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Electrospun chitosan-polyethylene oxide/TEMPO-oxidized cellulose (CS-PEO/TOC) bio-based composite was fabricated for the first time for water treatment applications. This new concept allows cellulose and chitosan to be combined in a simpler and efficient way, avoiding the use of harmful solvents, compared to previously published related work,. The "Sandwich-like" material is composed of a porous oxidized cellulosic fibers central core (TOC handsheet) and a thin layer of electrospun CS-PEO nanofibers on both sides of the core. Average diameters for CS-PEO and TOC were 159.3 ± 33.7 nm and 21.7 ± 5.1 µm, respectively. Fourier Transform Infrared Spectroscopy (FTIR) was carried out on the bio-based composite. Results suggest that no covalent bonds are involved but rather electrostatic interactions occur which allows bonding of the electrospun nanofiber layers on TOC core and no delamination. CS-PEO electrospinning time was varied to study the effect of nanofiber's coating weight on strength, permeability and adsorption capacity of the bio-based material. Mechanical properties of the composite were improved over the electrospun nanofiber mat. The CS-PEO provides greater elasticity (strain %) and the TOC provides a higher tensile strength to the material. However, tensile index was reduced by 48% with electrospinning time, while burst index was almost constant. The best conditions were achieved for 2 h electrospinning time. Under these conditions, a high permeable material (290.13 L/m 2 hbar) was developed. The adsorption capacity for Cu (II) ions reached up to 27% with only 12 mg of chitosan onto the CS-PEO/TOC (12.42 mg/g). The data fit better to the pseudo-second order model, suggesting chemisorption as the main mechanism involved for copper adsorption. This study opens-up potential opportunities for the development of a robust material for wastewater applications at an industrial scale.

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Section: Mechanical Properties Of Sorbent Materialssupporting

confidence: 93%

Cellulose reinforced electrospun chitosan nanofibers bio-based composite sorbent for water treatment applications

et al. 2021

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“…The nanofibers mat was heated from 20 to 400°C at a rate of 10°C/min and then they were cooled at room temperature. An empty pan was used as reference 19 …”

Section: Methodsmentioning

confidence: 99%

PVA/PMMA polymer blended composite electrospun nanofibers mat and their potential use as an anti‐biofilm product

Singh

Chauhan

Das

et al. 2020

J of Applied Polymer Sci

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Bacterial infections have increased dramatically due to microbial biofilm formation resulting in chronic pathological conditions in human subjects. Microbial biofilm causes poor drug penetration and antibiotic resistance, which has made site‐specific sustained drug delivery the most appropriate option. Our work entails fabrication of ciprofloxacin hydrochloride (CPX) loaded nanofibers using polyvinyl alcohol (PVA) and poly(meth) methacrylate (PMMA) employing electrospinning method to form PVA:PMMA:CPX nanofibers mat. These nanofibers mat were optimized, characterized, and further subjected to anti‐biofilm activity. Microscopic images revealed average nanofibers diameter of 243 ± 80 nm with smooth surface morphology. Analytical graphs and thermal analysis confirmed drug encapsulation and drug‐polymer compatibility. In vitro studies demonstrated sustained release of CPX for 22 days displaying Hixon Crowell and two‐stage desorption kinetics. Anti‐biofilm activity showed zones of inhibition 3.0 ± 0.5 cm, 2.8 ± 0.1 cm, 2.9 ± 0.2 cm for Escherichia coli, Staphylococcus aureus, Enterococcus faecalis, respectively which was well above the minimum inhibitory concentration levels of the bacteria forming biofilm. Conclusively, these nanofibers mat have potential to be used as an anti‐biofilm product.

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“… SEM images of different composite nanofibers for various biomedical applications: ( a ) chitosan–polyethylene oxide (PEO) composite nanofibers [ 43 ] (Copyright 2019, MDPI); ( b ) L929 cell seeded on carboxyethyl chitosan/polyvinyl alcohol (PVA) nanofibrous membrane after 48-h culture [ 44 ] (Copyright 2011, Elsevier); ( c ) cross-section of PCL/collagen nanofiber scaffolds [ 45 ] (Copyright 2009, Elsevier); ( d ) TEM image of highly aligned poly lactic- co -glycolic acid (PLGA)–gelatin nanofibers with 10 wt.% mesoporous silica nanoparticles [ 33 ] (Copyright 2015, Elsevier). …”

Section: Figurementioning

confidence: 99%

Functional Nanofibrous Biomaterials of Tailored Structures for Drug Delivery—A Critical Review

Shunqi

Dong

et al. 2020

Pharmaceutics

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Nanofibrous biomaterials have huge potential for drug delivery, due to their structural features and functions that are similar to the native extracellular matrix (ECM). A wide range of natural and polymeric materials can be employed to produce nanofibrous biomaterials. This review introduces the major natural and synthetic biomaterials for production of nanofibers that are biocompatible and biodegradable. Different technologies and their corresponding advantages and disadvantages for manufacturing nanofibrous biomaterials for drug delivery were also reported. The morphologies and structures of nanofibers can be tailor-designed and processed by carefully selecting suitable biomaterials and fabrication methods, while the functionality of nanofibrous biomaterials can be improved by modifying the surface. The loading and releasing of drug molecules, which play a significant role in the effectiveness of drug delivery, are also surveyed. This review provides insight into the fabrication of functional polymeric nanofibers for drug delivery.

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High Efficiency Fabrication of Chitosan Composite Nanofibers with Uniform Morphology via Centrifugal Spinning

Cited by 53 publications

References 61 publications

Cellulose reinforced electrospun chitosan nanofibers bio-based composite sorbent for water treatment applications

Cellulose reinforced electrospun chitosan nanofibers bio-based composite sorbent for water treatment applications

PVA/PMMA polymer blended composite electrospun nanofibers mat and their potential use as an anti‐biofilm product

Functional Nanofibrous Biomaterials of Tailored Structures for Drug Delivery—A Critical Review

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