High Dose Zolpidem Induced Fetal Neural Tube Defects

Sharma, Avinash; Sayeed, Neha; Khess, Christoday Raja Jayant; Akhtar, Sayeed

doi:10.2174/157488611795684695

Cited by 11 publications

(2 citation statements)

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“…Additionally, toxicology research does present this class of drugs as potentially hazardous in terms of risk of poisoning and adverse neuropsychiatric events that include parasomnia, hallucination, and amnesia. There have also been cases reported of women abusing zolpidem—in one case study exposure in the first trimester produced neural tube defects, suggesting that teratogenicity is possible at high enough doses [194].…”

Section: Effects Of Maternal Pharmacotherapy On Fetal Neonatal Amentioning

confidence: 99%

Use of Prescribed Psychotropics during Pregnancy: A Systematic Review of Pregnancy, Neonatal, and Childhood Outcomes

Creeley

Denton

2019

Brain Sciences

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This paper reviews the findings from preclinical animal and human clinical research investigating maternal/fetal, neonatal, and child neurodevelopmental outcomes following prenatal exposure to psychotropic drugs. Evidence for the risks associated with prenatal exposure was examined, including teratogenicity, neurodevelopmental effects, neonatal toxicity, and long-term neurobehavioral consequences (i.e., behavioral teratogenicity). We conducted a comprehensive review of the recent results and conclusions of original research and reviews, respectively, which have investigated the short- and long-term impact of drugs commonly prescribed to pregnant women for psychological disorders, including mood, anxiety, and sleep disorders. Because mental illness in the mother is not a benign event, and may itself pose significant risks to both mother and child, simply discontinuing or avoiding medication use during pregnancy may not be possible. Therefore, prenatal exposure to psychotropic drugs is a major public health concern. Decisions regarding drug choice, dose, and duration should be made carefully, by balancing severity, chronicity, and co-morbidity of the mental illness, disorder, or condition against the potential risk for adverse outcomes due to drug exposure. Globally, maternal mental health problems are considered as a major public health challenge, which requires a stronger focus on mental health services that will benefit both mother and child. More preclinical and clinical research is needed in order to make well-informed decisions, understanding the risks associated with the use of psychotropic medications during pregnancy.

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Section: Effects Of Maternal Pharmacotherapy On Fetal Neonatal Amentioning

confidence: 99%

Use of Prescribed Psychotropics during Pregnancy: A Systematic Review of Pregnancy, Neonatal, and Childhood Outcomes

Creeley

Denton

2019

Brain Sciences

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“…For example the imidazopyridine drug Zolpidem has been considered relatively safe for use in pregnancy, although some studies suggest that its use, particularly in high dose, may be associated with adverse outcomes including low birth-weight infants, preterm deliveries, small for gestational age infants, and cesarean delivery or even fetal neural tube defects. 40,41 RLS, which is associated with low serum ferritin and folate levels, can lead to sleep deprivation and severe mood swings.…”

Section: Treatment and Preventionmentioning

confidence: 99%

Sleep Abnormalities in Pregnancy: Review

Eser¹,

Kaygusuz²,

Gümüş³

et al. 2015

Turkiye Klinikleri J Gynecol Obst

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A AB BS S T TR RA AC CT T Pregnancy and sleep disorders are strongly correlated. Sleep disorders commonly experienced in pregnancy include insomnia, restless legs syndrome, excessive daytime sleepiness and sleep disordered breathing, for example sleep apnea. Causes can be physical discomfort, hormonal changes, alterations in respiratory physiology and psychological and emotional upheaval. Incidence of the different types of sleep disorders varies depending on pregnancy trimester. The first trimester is associated with excessive daytime sleepiness, although this can continue throughout pregnancy. Physical factors such as nausea and vomiting and hormonal changes are important causes. By the second trimester, hormonal changes are stabilising but women may still suffer sleep problems due to enlarged abdomen causing low back pain, abrupt fetal movements, heartburn and nocturia. In the third trimester, the majority of women suffer from sleep problems. Incidence of insomnia and restless legs syndrome reach their maximum. Sleep disordered breathing issues including sleep apnea, snoring and hypoventilation are also more common, influenced by rising progesterone levels, disordered and periodic breathing, excessive weight gain and altered neck circumference. Sleep disorders in pregnancy have been associated with adverse maternal and fetal outcomes. Treatment options include improving sleep hygiene, exercise, positional therapy, continuous positive airway pressure, behavioural therapies and, where the sleep disorders are refractory to these types of interventions, short-term pharmacological treatment with suitable hypnotics. Postpartum, many of the pregnancy-associated sleep disorders resolve, however many women continue to experience excessive daytime sleepiness and both pre-and post-partum sleep disorders have been linked to incidence of post-natal depression.K Ke ey y W Wo or rd ds s: : Sleep; pregnancy; sleep disorders Ö ÖZ ZE ET T Gebelik ve uyku bozuklukları arasında kuvvetli bir ilişki vardır. Gebelikte sıklıkla yaşanan uyku bozuklukları insomnia, huzursuz bacak sendromu, gündüz aşırı uyku hali ve uyku apnesi gibi uykuda nefes bozukluklarıdır. Nedenleri fiziksel rahatsızlık, hormonal değişiklikler, solunum fizyolojisindeki değişimler, psikolojik ve duygusal sarsıntılardır. Çeşitli tipteki uyku bozukluklarının insidansı trimesterlere göre değişiklik göstermektedir. İlk trimester gündüz aşırı uyku hali ile ilişkilidir, ancak bu durum gebelik boyunca devam edebilir. Bulantı kusma gibi fiziksel faktörler ve hormonal değişiklikler önemli nedenlerdir. İkinci trimesterle birlikte hormonal değişiklikler stabilize olur fakat kadınlar, genişlemiş karnın neden olduğu sırt ağrısına, ani fetüs hareketlerine, mide yanması ve noktüriye bağlı olarak, uyku problemlerinden hala şikayetçi olabilirler. Üçüncü trimesterde kadınların büyük çoğunluğu uyku problemleri yaşayabilirler. İnsomnia ve huzursuz bacak sendromu insidansı maksimum seviyeye ulaşır. Yükselen progesteron düzeyleri, düzensiz ve periyodik solunum, aşırı kilo alımı ve deği...

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Pharmacotherapy of Sleep Disorders During Pregnancy and Nursing

Mikoteit

Hatzinger

2022

NeuroPsychopharmacotherapy

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High Dose Zolpidem Induced Fetal Neural Tube Defects

Cited by 11 publications

References 0 publications

Use of Prescribed Psychotropics during Pregnancy: A Systematic Review of Pregnancy, Neonatal, and Childhood Outcomes

Use of Prescribed Psychotropics during Pregnancy: A Systematic Review of Pregnancy, Neonatal, and Childhood Outcomes

Sleep Abnormalities in Pregnancy: Review

Pharmacotherapy of Sleep Disorders During Pregnancy and Nursing

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