1972
DOI: 10.1111/j.1471-0528.1972.tb15741.x
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HIGH‐DOSE INTRAVENOUS ADMINISTRATION OF PROSTAGLANDIN E2 AND F FOR THE TERMINATION OF MIDTRIMESTER PREGNANCIES

Abstract: Intravenous prostaglandins E2 and F,, were administered for the induction of abortion in 20 patients. A steeply increasing high-dose regime was employed. Side effects were closely monitored and blood and urine analyses carried out before, during and after infusion. Compared with a low-dose regime previously reported the efficacy of the method was disappointing while the incidence of toxic effects was high. Leucocytosis and ketonuria were common findings. In three patients curtailment of infusion of PGF,, was n… Show more

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Cited by 33 publications
(7 citation statements)
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“…Since PGs can cause diarrhoea (Karim, 1971;Hillier and Embrey, 1972), PG synthetase activity has been studied in the irritable bowel syndrome and in ulcerative colitis, two conditions in which diarrhoea is an important symptom.…”
mentioning
confidence: 99%
“…Since PGs can cause diarrhoea (Karim, 1971;Hillier and Embrey, 1972), PG synthetase activity has been studied in the irritable bowel syndrome and in ulcerative colitis, two conditions in which diarrhoea is an important symptom.…”
mentioning
confidence: 99%
“…Using intravenous PGE2 (2-5 ug/min) Embrey (1970b) induced abortion in 90°o" of cases. However, using a high-dose regimen (PGE2 2-5-20 scg/min; PGF2, 25-200 tg/min) we induced abortion in only 5000 of patients (Hillier, 1971;Hillier and Embrey, 1972). Filshie (1970a, 1970b) obtained a high success rate with low-dose administration (5 ,ug/min PGE,; 50 tg/min PGF, e), whereas Wiqvist et al (1971a) found a mean dose of 108 ,tg/min PGF2 ce was required to achieve comparable success.…”
Section: Discussionmentioning
confidence: 99%
“…Attempts to shorten the infusion time by using larger doses were disappointing and resulted only in an intolerable level of side effects (Hillier and Embrey, 1972).…”
Section: Introductionmentioning
confidence: 99%
“…High doses are required before progesterone levels are affected; and this is associated with side effects similar to those seen during PGF,oc infusion in early pregnancy (Hillier and Embrey, 1972).…”
Section: Discussionmentioning
confidence: 99%