High-dose biotin for multiple sclerosis: A systematic review and meta-analyses of randomized controlled trials

Espiritu, Adrian I.; Remalante-Rayco, Patricia Pauline M.

doi:10.1016/j.msard.2021.103159

Cited by 12 publications

(6 citation statements)

References 37 publications

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“…Last but not least, it is obvious that high-dose biotin has emerged as a promising therapy for RRMS cases, as it promotes axonal remyelination by enhancing myelin production and by reducing axonal hypoxia through enhanced energy production [132]. However, biotin interference in immunoassays is a common event, since there are reports of false test results [133,134]. Also, biotin at various concentrations is taken as a nutrient supplement, further increasing concerns as to whether such supplementation may interfere with immunoassay testing.…”

Section: Molecular Diagnosis Of Jcpyv Antigens and Anti-jcpyv Antibodiesmentioning

confidence: 99%

John Cunningham Virus and Progressive Multifocal Leukoencephalopathy: A Falsely Played Diagnosis

Mouliou

2024

Diseases

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Progressive Multifocal Leukoencephalopathy (PML) is a possibly fatal demyelinating disease and John Cunningham Polyomavirus (JCPyV) is believed to cause this condition. The so-called JCPyV was initially reported in lymphoma and Human Immunodeficiency Virus (HIV) cases, whereas nowadays, its incidence is increasing in Multiple Sclerosis (MS) cases treated with natalizumab (Tysabri). However, there are conflicting literature data on its pathology and diagnosis, whereas some misdiagnosed reports exist, giving rise to further questions towards the topic. In reality, the so-called PML and the supposed JCPyV are not what they seem to be. In addition, novel and more frequent PML-like conditions may be reported, especially after the Coronavirus Disease 2019 (COVID-19) pandemic.

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Section: Molecular Diagnosis Of Jcpyv Antigens and Anti-jcpyv Antibodiesmentioning

confidence: 99%

John Cunningham Virus and Progressive Multifocal Leukoencephalopathy: A Falsely Played Diagnosis

Mouliou

2024

Diseases

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“…Another issue that has recently come to light is biotin (vitamin B7) interference in certain immunoassays [ [50] , [51] ]. Biotin, an over-the-counter supplement used to strengthen nails and hair, is becoming more common, and supraphysiological high dose biotin has been used in clinical trials to try to slow down the progression of multiple sclerosis [ 52 ]. This interference is analytical, where biotin in the patient sample can lead to falsely elevated results in a competitive immunoassay design, and falsely low results in a non-competitive immunoassay design that uses streptavidin binding in the detection mechanism.…”

Section: Common Immunoassay Limitations Mitigated By Laboratory Devel...mentioning

confidence: 99%

Clinical utility of laboratory developed mass spectrometry assays for steroid hormone testing

French¹

2023

Journal of Mass Spectrometry and Advances in the Clinical Lab

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“…Ключевое значение опосредовано участием в работе ацетилкарбоксилазы -биотин-зависимого фермента, который катализирует карбоксилацию ацетила-СоА, что играет роль как при патологии ЦНС, так и при периферической нейропатии [32]. Получены обнадеживающие результаты применения высоких доз биотина при рассеянном склерозе [33,34].…”

Section: витамин в 7 (биотин)unclassified

Neurotropic B vitamins effects: overview

Vertkin,

Knorring,

Aliev

2023

Russian Medical Inquiry

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The importance of pain syndromes is obvious not only medically but also socially. Dissatisfaction with the pain relief efficacy, a variety of pathogenetic mechanisms dictate the need to search for new and/or additional analgesics. Previously, the role of neurotropic B vitamins, potentiating analgesic therapy, and having their base potential, including additional effects, was convincingly shown. However, the role of vitamins in this group turned out to be much more important and covers a wide range of vital aspects of the body functioning as a whole and the nervous system in particular. The article considers the importance of vitamins in the following: ensuring the energy metabolism of nervous tissue, regulation of neurons key processes, key neurotransmitters metabolism, structural components, as well as removal of neurotoxic substances. The article also emphasizes synergistic, cooperative effect of these vitamins, as well as it describes their role in the normal state and in the pathology development, including those mediated by vitamin deficiencies. The available data on the use of the entire B vitamins palette, both experimental and clinical, in the treatment of pain syndromes, pathology of the central and peripheral nervous system is analyzed. KEYWORDS: pain, nervous system, neurodegeneration, B vitamins, thiamine, riboflavin, pyridoxine, folic acid, cyanocobalamin. FOR CITATION: Vertkin A.L., Knorring G.Yu., Aliev Z.K. Neurotropic B vitamins effects: overview. Russian Medical Inquiry. 2023;7(10):650–657 (in Russ.). DOI: 10.32364/2587-6821-2023-7-10-6.

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High-dose biotin for multiple sclerosis: A systematic review and meta-analyses of randomized controlled trials

Cited by 12 publications

References 37 publications

John Cunningham Virus and Progressive Multifocal Leukoencephalopathy: A Falsely Played Diagnosis

John Cunningham Virus and Progressive Multifocal Leukoencephalopathy: A Falsely Played Diagnosis

Clinical utility of laboratory developed mass spectrometry assays for steroid hormone testing

Neurotropic B vitamins effects: overview

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