Neurotropic B vitamins effects: overview

Abstract

The importance of pain syndromes is obvious not only medically but also socially. Dissatisfaction with the pain relief efficacy, a variety of pathogenetic mechanisms dictate the need to search for new and/or additional analgesics. Previously, the role of neurotropic B vitamins, potentiating analgesic therapy, and having their base potential, including additional effects, was convincingly shown. However, the role of vitamins in this group turned out to be much more important and covers a wide range of vital aspects of the body functioning as a whole and the nervous system in particular. The article considers the importance of vitamins in the following: ensuring the energy metabolism of nervous tissue, regulation of neurons key processes, key neurotransmitters metabolism, structural components, as well as removal of neurotoxic substances. The article also emphasizes synergistic, cooperative effect of these vitamins, as well as it describes their role in the normal state and in the pathology development, including those mediated by vitamin deficiencies. The available data on the use of the entire B vitamins palette, both experimental and clinical, in the treatment of pain syndromes, pathology of the central and peripheral nervous system is analyzed. KEYWORDS: pain, nervous system, neurodegeneration, B vitamins, thiamine, riboflavin, pyridoxine, folic acid, cyanocobalamin. FOR CITATION: Vertkin A.L., Knorring G.Yu., Aliev Z.K. Neurotropic B vitamins effects: overview. Russian Medical Inquiry. 2023;7(10):650–657 (in Russ.). DOI: 10.32364/2587-6821-2023-7-10-6.