High-Density Lipoproteins and Apolipoprotein A1

Vorst, Emiel P. C. van der

doi:10.1007/978-3-030-41769-7_16

Cited by 63 publications

(46 citation statements)

References 94 publications

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“…This LPL protein hydrolyses circulating triglycerides into chylomicrons and VLDL into free fatty acids and glycerol, which are further converted in HDL and LDL [42]. In addition, the lack of HDL also aggravates the inflammatory state, since its main protein, apolipoprotein A-I, binds to T-lymphocytes and prevents monocyte activation, inhibiting TNF-α production [50,51]. This anti-inflammatory effect of HDL is strongly reinforced by accumulative evidence that reveals a disturbance in the composition of lipoproteins in IBD patients [52,53].…”

Section: Sterol Lipidsmentioning

confidence: 99%

Metabolomics as a Promising Resource Identifying Potential Biomarkers for Inflammatory Bowel Disease

Bauset

Gisbert-Ferrándiz

Cosín-Roger

2021

JCM

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Inflammatory bowel disease (IBD) is a relapsing chronic disorder of the gastrointestinal tract characterized by disruption of epithelial barrier function and excessive immune response to gut microbiota. The lack of biomarkers providing early diagnosis or defining the status of the pathology difficulties an accurate assessment of the disease. Given the different metabolomic profiles observed in IBD patients, metabolomics may reveal prime candidates to be studied, which may help in understanding the pathology and identifying novel therapeutic targets. In this review, we summarize the most current advances describing the promising metabolites such as lipids or amino acids found through untargeted metabolomics from serum, faecal, urine and biopsy samples.

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Section: Sterol Lipidsmentioning

confidence: 99%

Metabolomics as a Promising Resource Identifying Potential Biomarkers for Inflammatory Bowel Disease

Bauset

Gisbert-Ferrándiz

Cosín-Roger

2021

JCM

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“…4e-g). In summary, exploration of ApoA-I and HDL as therapeutics in cardiovascular disease and for metabolic control has, despite many attempts, not yet resulted in any viable treatment (reviewed in 26,27 ). The RG33 peptide, which corresponds to the C-terminal residues 209-241 of the ApoA-I protein, efficiently promotes cholesterol efflux from macrophages and provide systemic glucose control in an insulin resistant mouse model.…”

Section: Resultsmentioning

confidence: 99%

A short peptide of the C-terminal class Y helices of apolipoprotein A-I has preserved functions in cholesterol efflux and in vivo metabolic control

Edmunds

Liébana-García

Stenkula

et al. 2020

Sci Rep

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Apolipoprotein A-I (ApoA-I) of high-density lipoprotein (HDL) induces glucose uptake by muscle tissues and stimulates pancreatic insulin secretion, and also facilitates cholesterol transport in circulation, and is explored for anti-diabetic and anti-atherosclerotic treatments. As the better alternative to complex protein–lipid formulations it was recently established that the C-terminal region of the ApoA-I protein singly improves the metabolic control and prevents formation of atherosclerotic plaques. Additional investigations of peptides based on the ApoA-I structure may lead to novel anti-diabetic drugs. We here investigate a short peptide (33mer, RG33) that corresponds to the two last helical segments (aa 209–241) of the ApoA-I structure (so-called class Y-helices which forms amphipathic helices) for stability and solubility in serum, for in vitro cholesterol efflux capability, and for providing in vivo glucose control in an insulin resistant mouse model. The RG33 peptide efficiently solubilizes lipid-vesicles, and promotes the efflux of cholesterol from cultured macrophages. The efflux capacity is significantly increased in the presence of lipids compared to non-lipidated RG33. Finally, acute treatment with the RG33 peptide significantly improves the glucose clearance capacity of insulin resistant mice. The impact of the RG33 peptide on glucose control and cholesterol transport, as well as the physicochemical properties, makes it a good candidate for translational exploration of its therapeutic potential in diabetes treatment.

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“…We found two proteins that were commonly had high expression in both myopia and control groups. APOA1 encodes apolipoprotein A I, which is the major protein component of high-density lipoprotein (HDL) in the plasma [36]. APOA1 protein has been found in exosomes derived from the saliva, urine, platelets, and hepatocytes [30,31,37,38].…”

Section: Discussionmentioning

confidence: 99%

Proteomic analysis of Exosomes derived from the Aqueous Humor of Myopia Patients

Tsai¹,

Chen²,

Lin³

et al. 2021

Int. J. Med. Sci.

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Objectives: Myopia is the most common refractive vision disorder. In recent years, several studies have suggested that the alteration of the exosomal protein levels in the aqueous humor (AH) is associated with the development of several eye diseases. Therefore, we aimed to explore the exosomal protein profile of the AH from myopia patients. Methods: Exosomes were isolated from the AH. The quality, concentration, and size distribution of exosomes for each patient were measured using nanoparticle tracking analysis system. Then, the exosomal proteins were purified and digested by trypsin for liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis. Results: There was no significant difference observed between the myopia and control when comparing the concentration and size distribution of exosomes in the AH for each sample. Based on LC-MS/MS analysis, myopia patients had higher and more complex exosomal peptide content. We found two proteins that were common in AH exosomes and eight proteins that were highly expressed in the myopia group. Conclusions: Our results provide pioneering findings for the exploration of the exosomal protein profile in myopia development. Further studies may provide significant information for the diagnosis, clinical treatment, and prognosis of myopia.

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High-Density Lipoproteins and Apolipoprotein A1

Cited by 63 publications

References 94 publications

Metabolomics as a Promising Resource Identifying Potential Biomarkers for Inflammatory Bowel Disease

Metabolomics as a Promising Resource Identifying Potential Biomarkers for Inflammatory Bowel Disease

A short peptide of the C-terminal class Y helices of apolipoprotein A-I has preserved functions in cholesterol efflux and in vivo metabolic control

Proteomic analysis of Exosomes derived from the Aqueous Humor of Myopia Patients

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