High-Density Lipoproteins: A Role in Inflammation in COPD

Abstract

Chronic obstructive pulmonary disease (COPD) is a widespread disease associated with high rates of disability and mortality. COPD is characterized by chronic inflammation in the bronchi as well as systemic inflammation, which contributes significantly to the clinically heterogeneous course of the disease. Lipid metabolism disorders are common in COPD, being a part of its pathogenesis. High-density lipoproteins (HDLs) are not only involved in lipid metabolism, but are also part of the organism’s immune and antioxidant defense. In addition, HDL is a versatile transport system for endogenous regulatory agents and is also involved in the removal of exogenous substances such as lipopolysaccharide. These functions, as well as information about lipoprotein metabolism disorders in COPD, allow a broader assessment of their role in the pathogenesis of heterogeneous and comorbid course of the disease.

WITHDRAWN: Relationship between NMLR and all-cause mortality in patients with chronic obstructive pulmonary disease: National Health and Nutrition Examination Survey, 1999–2018

“…Chronic in ammation is a key factor in COPD, and has been implicated in the severity of deterioration of COPD patients [4][5][6] . In ammatory cells, including macrophages and neutrophils, are part of the innate immune defense system in the lungs [7] . As such, immune dysfunction frequently leads to the exacerbation of COPD [8] .…”

Comparative serum lipid and immunohematological values among adult pulmonary tuberculosis and tuberculosis lymphadenitis cases and their association with sputum bacilli load and time to culture positivity in Northwestern Ethiopia

“…High-density lipoprotein is involved in lipid metabolism, organism’s immune and antioxidant defense and has a role in transport and in the removal of exogenous substances [ 62 ]. Unfortunately, the value of this good lipid is below the normal range for both groups of TB patients.…”

Lipid-Sensing Receptor FFAR4 Modulates Pulmonary Epithelial Homeostasis following Immunogenic Exposures Independently of the FFAR4 Ligand Docosahexaenoic Acid (DHA)

“…These results broaden the scope for FFAR4-signaling and pose new questions as to its role in lung homeostasis. Chronic inflammatory diseases, such as COPD and diabetes mellitus, are hallmarked by altered lipoprotein profiles and lipid metabolism disorders causing cardiovascular comorbidities [ 84 , 85 ]. A high-fat diet and diabetic dyslipidemia induces atherosclerosis and lipoprotein imbalances in human and non-human studies [ 86 , 87 ].…”