High-density lipoprotein subclasses distribution and composition in Mexican adolescents with low HDL cholesterol and/or high triglyceride concentrations, and its association with insulin and c-reactive protein

Moeini, Aida; Juárez-Rojas, Juan Gabriel; Martínez-Alvarado, Rocío; Jorge‐Galarza, Esteban; Posadas-Sánchez, Rosalinda; Cardoso-Saldaña, Guillermo; Caracas-Portilla, Nacu; Mendoza-Pérez, Enrique; Posadas‐Romero, Carlos

doi:10.1016/j.atherosclerosis.2008.02.029

Cited by 21 publications

(15 citation statements)

References 31 publications

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“…HDL-C, with its atheroprotective effect, plays a crucial role in reverse cholesterol transport and facilitates the cholesterol transfer from peripheral tissues back to the liver . Medina-Urrutia et al (2008) reported that HDL-C levels are inversely associated with the development of CHD (Medina-Urrutia et al, 2008). Therefore, the results of our study reflected the conclusions of previous studies that NAT2 polymorphisms are a risk factor for CHD.…”

Section: Discussionsupporting

confidence: 81%

Association of N-acetyltransferase-2 polymorphism with an increased risk of coronary heart disease in a Chinese population

Sun

Yuan

et al. 2016

Genet. Mol. Res.

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ABSTRACT.We investigated the possible correlations between N-acetyltransferase-2 (NAT2) gene polymorphisms and the risk of coronary heart disease (CHD). CHD patients (113) and healthy controls (118) were enrolled from the First People's Hospital of Yuhang between January 2013 and June 2014. The patients were divided into mild CHD (N = 72) and severe CHD (N = 41) subgroups. DNA samples were extracted and the distributions of NAT2 polymorphisms were examined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Clinical characteristic indexes of severe CHD patients were also examined for relevant statistical analysis. WT, M1, M2, and M3 alleles were observed in both case and control groups. PCR-RFLP identified a wild-type homozygote, WT/WT; a mutant heterozygote, WT/Mx; and a mutant homozygote, Mx/Mx (x = 1, 2, and 3) variant of the NAT2 genotype. Mx/Mx differed significantly between case and control groups (P < 0.05); the frequencies of all four alleles did not differ significantly between case and control groups (P > 0.05). Slow acetylator genotype frequencies were notably higher in the case group than in the control group (P < 0.05). Individuals with the slow acetylator genotype were at 1.97-times higher risk of CHD and also displayed higher triglyceride and lower high-density lipoprotein cholesterol levels than those with the rapid acetylator genotype (P < 0.05). Therefore, the NAT2 polymorphism was believed to be associated with increased risk of CHD, with the NAT2 slow acetylator genotype serving as a risk factor for severe CHD in a Chinese population.

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Section: Discussionsupporting

confidence: 81%

Association of N-acetyltransferase-2 polymorphism with an increased risk of coronary heart disease in a Chinese population

Sun

Yuan

et al. 2016

Genet. Mol. Res.

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“…Furthermore, in Mexican adolescents, HDL subclass distribution was reported to be independently associated with WC. 5 In South Indian Asian women, small and dense subclasses of HDL were associated with higher levels of insulin resistance but not with WC. 6 Other explanations for variations in HDL levels have been proposed; for example, low HDL-C levels have been described in correlation with the K219 allele, a genetic variant of ABCA1 with a frequency which markedly differs between blacks and whites, and which modulates the association between age and HDL-cholesterol, as well as body fatness and triglycerides in a beneficial manner in whites versus young blacks.…”

Section: Discussionmentioning

confidence: 99%

“…[2][3][4] Few studies have specifically analysed the relationship between abdominal obesity and the distribution of HDL and LDL subfractions. [5][6][7] The aim of our study was to determine the influence of visceral fat hypertrophy, assessed by waist circumference (WC), on the distribution of HDL and LDL particles in overweight patients with abdominal obesity and no lipidlowering treatment.…”

Section: Introductionmentioning

confidence: 99%

Waist circumference is a strong and independent determinant of the distribution of HDL subfractions in overweight patients with cardiovascular risk factors

Rosenbaum

Hansel

Bonnefont‐Rousselot

et al. 2012

Diabetes and Vascular Disease Research

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Purpose: Our aim was to determine the influence of waist circumference on the repartition of high-density lipoprotein (HDL) and low-density lipoprotein (LDL) subfractions in patients with increased waist perimeter and one or more cardiovascular risk factor. Methods: All 117 patients without lipid-lowering therapy underwent routine clinical, biological evaluation and isolation of the following lipid subfractions: HDL2b, HDL2a, HDL3a, HDL3b, HDL3c and LDL1, LDL2, LDL3, LDL4. Results: Mean waist circumference was 102.9 cm for women and 109.4 cm for men, and 92 patients presented with metabolic syndrome. In the highest waist circumference tertile, when compared with the lowest one, an increased HDL3c (7.7% vs. 5.7% p=0.02) and a non-significant decrease of HDL2b percentages were observed with no difference in other subfractions. In multivariate analysis, only plasma triglycerides and waist circumference remained independent predictors of HDL3c percentage. Conclusion: In our population, waist circumference was a strong and independent determinant of a shift in the distribution of HDL toward denser particles.

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“…Notably the prevalent level of exercise was not evaluated in these populations. 10 Analysis of the clinical questionnaires administered to the population sampled in our study revealed that both groups (diagnosed and controls) routinely carried out a regular regime of daily, one hour or more exercise. Therefore this population may be markedly different from the more sedentary individuals that manifest early signs of overweight or obesity, who encompass a greater number of factors linked to the metabolic syndrome.…”

Section: Discussionmentioning

confidence: 99%

Nonobese, exercising children diagnosed with dyslipidemia have normal C-reactive protein

Vázquez

Vázquez²,

Intaglietta³

et al. 2008

VHRM

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Nonobese children age 10.4 ± 1.1 years diagnosed with dyslipidemia (n = 51) were compared to normal children age 10.8 ± 1.1 years (n = 38). Affected individuals had increased total cholesterol: 223 ± 23 vs 152 ± 17 mg/dl, p Ͻ 0.001; and decreased high-density lipoprotein-cholesterol: 41.9 ± 4.1 vs 57.6 ± 5.7 mg/dl, p Ͻ 0.001 and triglycerides: 90.8 ± 40.5 vs 65.7 ± 25.0 mg/dl, p Ͻ 0.002. Fasting glucose was also signifi cantly elevated (p Ͻ 0.02). All other parameters, including blood pressure, were not statistically different between groups. The concentration of C-reactive protein was not statistically different between groups. Analysis of medical records showed that this anomaly may be related to this group (as well as the control group) performing regular, daily exercise. This activity was quantifi ed via a self administered questionnaire, and found to be statistically identical in controls and dyslipidemic individuals. Exercise is associated with the release of antiinfl ammatory cytokines, therefore our results support the contention that it is a signifi cant factor in promoting health conditions from an early stage in life.

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High-density lipoprotein subclasses distribution and composition in Mexican adolescents with low HDL cholesterol and/or high triglyceride concentrations, and its association with insulin and c-reactive protein

Cited by 21 publications

References 31 publications

Association of N-acetyltransferase-2 polymorphism with an increased risk of coronary heart disease in a Chinese population

Association of N-acetyltransferase-2 polymorphism with an increased risk of coronary heart disease in a Chinese population

Waist circumference is a strong and independent determinant of the distribution of HDL subfractions in overweight patients with cardiovascular risk factors

Nonobese, exercising children diagnosed with dyslipidemia have normal C-reactive protein

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