High-Density Lipoprotein: Multipotent Effects on Cells of the Vasculature

Cockerill, Gillian; Reed, Stephen C.

doi:10.1016/s0074-7696(08)61569-7

Cited by 32 publications

(13 citation statements)

References 152 publications

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“…However, there has been little direct evidence that changes in this pathway are associated with changes in HDL-C levels and susceptibility to CAD (30). Specifically, there has been no direct evidence linking efflux of cholesterol from peripheral cells, the initial step of the reverse cholesterol transport pathway, to CAD.…”

Section: Discussionmentioning

confidence: 99%

Age and residual cholesterol efflux affect HDL cholesterol levels and coronary artery disease in ABCA1 heterozygotes

Clee¹,

Kastelein²,

Dam³

et al. 2000

J. Clin. Invest.

300

188

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Section: Discussionmentioning

confidence: 99%

Age and residual cholesterol efflux affect HDL cholesterol levels and coronary artery disease in ABCA1 heterozygotes

Clee¹,

Kastelein²,

Dam³

et al. 2000

J. Clin. Invest.

300

188

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“…removal of excess cholesterol) from tissues to the liver and are antiinflammatory, modulating, for example, the effect of TNF and IL (see Cockerill & Reed, 1999 for a review, and Cockerill et al 2001).…”

Section: Pathogenesismentioning

confidence: 99%

The impact of long-chainn-3 polyunsaturated fatty acids on human health

et al. 2005

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A considerable literature has been published on the health benefits of fish, oil-rich fish and fish oils and their constituent long-chain (LC)n-3 PUFA. Evidence from epidemiological studies highlights the cardioprotective attributes of diets rich in fish, especially oil-rich fish. Data from intervention trials are consistent in suggesting that LCn-3 PUFA lower the risk of CVD, probably by the multiple mechanisms of lowering serum triacylglycerols, improving the LDL:HDL ratio, anti-arrhythmic effects on heart muscle, improved plaque stability, anti-thrombotic effects and reduced endothelial activation. Research indicates LCn-3 PUFA provision has an impact during development, and there is preliminary evidence that docosahexaenoic acid supplementation during pregnancy could optimise brain and retina development in the infant. LCn-3 PUFA are also postulated to ameliorate behavioural and mental health disturbances such as depression, schizophrenia, dementia and attention deficit hyperactivity disorder. However, despite some positive evidence in each of these areas, use of LCn-3 PUFA in these conditions remains at the experimental stage. In the case of immune function, there is little doubt that LCn-3 PUFA have a positive effect. Although intervention trials in rheumatoid arthritis show strong evidence of benefit, evidence for efficacy in other inflammatory conditions, including Crohn's disease, ulcerative colitis, psoriasis, lupus, multiple sclerosis, cystic fibrosis and asthma, is inconsistent or inadequate. More promising evidence in some conditions may come from studies which attempt to modify the fetal environment using LCn-3 PUFA supplementation during pregnancy.

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“…Extensive epidemiological research supports a key role of HDLs and their major apolipoprotein A-I (apoA-I) in the prevention of coronary heart disease. Different protective capabilities have been attributed to HDL (1)(2)(3), including their critical participation in cholesterol catabolism.…”

mentioning

confidence: 99%

Interaction of high density lipoprotein particles with membranes containing cholesterol

Sánchez

Tricerri

Gratton

2007

Journal of Lipid Research

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In this study, free cholesterol (FC) efflux mediated by human HDL was investigated using fluorescence methodologies. The accessibility of FC to HDL may depend on whether it is located in regions rich in unsaturated phospholipids or in domains containing high levels of FC and sphingomyelin, known as "lipid rafts." Laurdan generalized polarization and two-photon microscopy were used to quantify FC removal from different pools in the bilayer of giant unilamellar vesicles (GUVs). GUVs made of POPC and FC were observed after incubation with reconstituted particles containing apolipoprotein A-I and POPC [78Å diameter reconstituted high density lipoprotein (rHDL)]. Fluorescence correlation spectroscopy data show an increase in rHDL size during the incubation period. GUVs made of two "raft-like" mixtures [DOPC/DPPC/FC (1:1:1) and POPC/SPM/FC (6:1:1)] were used to model liquidordered/liquid-disordered phase coexistence. Through these experiments, we conclude that rHDL preferentially removes cholesterol from the more fluid phases. These data, and their extrapolation to in vivo systems, show the significant role that phase separation plays in the regulation of cholesterol homeostasis.-Sanchez, S. A., M. A. Tricerri, and E. Gratton. Interaction of high density lipoprotein particles with membranes containing cholesterol. J. Lipid Res.

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High-Density Lipoprotein: Multipotent Effects on Cells of the Vasculature

Cited by 32 publications

References 152 publications

Age and residual cholesterol efflux affect HDL cholesterol levels and coronary artery disease in ABCA1 heterozygotes

Age and residual cholesterol efflux affect HDL cholesterol levels and coronary artery disease in ABCA1 heterozygotes

The impact of long-chainn-3 polyunsaturated fatty acids on human health

Interaction of high density lipoprotein particles with membranes containing cholesterol

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