High-density lipoprotein (HDL) particle size and concentration changes in septic shock patients

Tanaka, Sébastien; Diallo, Djibril; Delbosc, Sandrine; Geneve, Claire; Zappella, Nathalie; Yong-Sang, Jennyfer; Patché, Jessica; Harrois, Anatole; Hamada, Sophie; Denamur, Erick; Montravers, Philippe; Duranteau, Jacques; Meilhac, Olivier

doi:10.1186/s13613-019-0541-8

Cited by 60 publications

(68 citation statements)

References 48 publications

(52 reference statements)

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“…de la Llera et al have shown that LPS infusion in healthy volunteers led to a decrease of small-and medium-size particles without any change in the total number of HDL particles [72]. We have shown that HDL levels are dramatically decreased in the acute phase of septic shock and that there is a shift toward large HDL particles [86]. Another study underlined that both HDL size and HDL-C concentration were independently associated with coronary artery disease risk [87].…”

Section: Hdl Function In Inflammatory Statementioning

confidence: 49%

High-density lipoproteins during sepsis: from bench to bedside

et al. 2020

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High-density lipoproteins (HDLs) represent a family of particle characterized by the presence of apolipoprotein A-I (apoA-I) and by their ability to transport cholesterol from peripheral tissues back to the liver conferring them a cardioprotective function. HDLs also display pleiotropic properties including antioxidant, anti-apoptotic, antithrombotic, anti-inflammatory, or anti-infectious functions. Clinical data demonstrate that HDL cholesterol levels decrease rapidly during sepsis and that these low levels are correlated with morbi-mortality. Experimental studies emphasized notable structural and functional modifications of HDL particles in inflammatory states, including sepsis. Finally, HDL infusion in animal models of sepsis improved survival and provided a global endothelial protective effect. These clinical and experimental studies reinforce the potential of HDL therapy in human sepsis. In this review, we will detail the different effects of HDLs that may be relevant under inflammatory conditions and the lipoprotein changes during sepsis and we will discuss the potentiality of HDL therapy in sepsis.

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Section: Hdl Function In Inflammatory Statementioning

confidence: 49%

High-density lipoproteins during sepsis: from bench to bedside

et al. 2020

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“…We have compared the lipid profiles between septic and trauma patients, two situations in which inflammation is exacerbated. HDL-C levels were markedly lower in septic patients relative to trauma patients, whose concentration was normal [69]. The mechanisms underlying this decrease in HDL plasma concentrations are not fully understood but could be due to an increased turnover paralleled by a reduced hepatic synthesis [70].…”

Section: Hdl-c Levels In Sepsis: What Do We Learn From Clinical Studies?mentioning

confidence: 94%

High-Density Lipoproteins Are Bug Scavengers

2020

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Lipoproteins were initially defined according to their composition (lipids and proteins) and classified according to their density (from very low- to high-density lipoproteins—HDLs). Whereas their capacity to transport hydrophobic lipids in a hydrophilic environment (plasma) is not questionable, their primitive function of cholesterol transporter could be challenged. All lipoproteins are reported to bind and potentially neutralize bacterial lipopolysaccharides (LPS); this is particularly true for HDL particles. In addition, HDL levels are drastically decreased under infectious conditions such as sepsis, suggesting a potential role in the clearance of bacterial material and, particularly, LPS. Moreover, "omics" technologies have unveiled significant changes in HDL composition in different inflammatory states, ranging from acute inflammation occurring during septic shock to low-grade inflammation associated with moderate endotoxemia such as periodontal disease or obesity. In this review, we will discuss HDL modifications associated with exposure to pathogens including bacteria, viruses and parasites, with a special focus on sepsis and the potential of HDL therapy in this context. Low-grade inflammation associated with atherosclerosis, periodontitis or metabolic syndrome may also highlight the protective role of HDLs in theses pathologies by other mechanisms than the reverse transport of cholesterol.

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“…It has been suggested that distinct HDL subspecies have differential biological functions. For example, large HDL seems to be less anti-inflammatory [23,24], whereas small HDL subclasses may be enriched in either cargo or other components of HDL that are responsible for its alternative functions [25,26]. The summary of HDL functions in health and disease is presented in Figure 1.…”

Section: Hdl Role and Functionsmentioning

confidence: 99%

The Role and Function of HDL in Patients with Chronic Kidney Disease and the Risk of Cardiovascular Disease

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Rysz-Górzyńska

et al. 2020

IJMS

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Chronic kidney disease (CKD) is a worldwide health problem with steadily increasing occurrence. Significantly elevated cardiovascular morbidity and mortality have been observed in CKD. Cardiovascular diseases are the most important and frequent cause of death of CKD patients globally. The presence of CKD is related to disturbances in lipoprotein metabolism whose consequences are dyslipidemia and the accumulation of atherogenic particles. CKD not only fuels the reduction of high-density lipoprotein (HDL) cholesterol concentration, but also it modifies the composition of this lipoprotein. The key role of HDL is the participation in reverse cholesterol transport from peripheral tissues to the liver. Moreover, HDL prevents the oxidation of low-density lipoprotein (LDL) cholesterol by reactive oxygen species (ROS) and protects against the adverse effects of oxidized LDL (ox-LDL) on the endothelium. Numerous studies have demonstrated the ability of HDL to promote the production of nitric oxide (NO) by endothelial cells (ECs) and to exert antiapoptotic and anti-inflammatory effects. Increasing evidence suggests that in patients with chronic inflammatory disorders, HDLs may lose important antiatherosclerotic properties and become dysfunctional. So far, no therapeutic strategy to raise HDL, or alter the ratio of HDL subfractions, has been successful in slowing the progression of CKD or reducing cardiovascular disease in patients either with or without CKD.

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High-density lipoprotein (HDL) particle size and concentration changes in septic shock patients

Cited by 60 publications

References 48 publications

High-density lipoproteins during sepsis: from bench to bedside

High-density lipoproteins during sepsis: from bench to bedside

High-Density Lipoproteins Are Bug Scavengers

The Role and Function of HDL in Patients with Chronic Kidney Disease and the Risk of Cardiovascular Disease

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