High-density Lipoprotein-cholesterol Subfractions and Coronary Artery Calcium: The ELSA-Brasil Study

Generoso, Giuliano; Santos, Raúl D.; Staniak, Henrique Lane; Sharovsky, Rodolfo; Goulart, Alessandra Carvalho; Jones, Steven R.; Kulkarni, Krishnaji; Blaha, Michael J.; Tóth, Peter P.; Lotufo, Paulo A; Bittencourt, Márcio Sommer

doi:10.1016/j.arcmed.2019.10.006

Cited by 14 publications

(17 citation statements)

References 44 publications

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“…Various major biomarkers have been confirmed to be related to the occurrence of cardiovascular disease. It is found that people who are with high concentrations of low-density lipoprotein (LDL) cholesterol and triglyceride-rich lipoproteins [ 12 ] or low concentrations of high-density lipoprotein (HDL) cholesterol tend to suffer from CAD [ 13 ]. Interleukin-13 (IL-13) is a key cytokine involved in the occurrence of allergic diseases, which play an important role in inflammatory and immune responses [ 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

Circulating Levels of IL-13, TGF-β1, and Periostin as Potential Biomarker for Coronary Artery Disease with Acute Heart Failure

Qiu

Fengyi

Zhang

2021

Evidence-Based Complementary and Alternative Medicine

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Objective. Coronary artery disease (CAD) and associated comorbidities such as heart failure (HF) remain the leading cause of morbidity and mortality worldwide, attributed to, at least partially, the lack of biomarkers for efficient disease diagnosis. The study intended to explore potential biomarkers for predicting the presence of HF in CAD patients. Methods. According to the presence of HF, 83 CAD patients with HF were assigned to the AHF group and 52 CAD patients without HF to the CAD group. Additionally, healthy controls (n = 52) were those who had received physical examinations at the same period. The serum levels of IL-13, TGF-β1, and periostin were detected by the enzyme-linked immunosorbent assay (ELISA). Left ventricular ejection fraction (LVEF), left ventricular end-diastolic dimension (LVEDD), left ventricle-end diastolic volume (LVEDV), and left ventricular mass index (LVMI) were detected 3 times by color Doppler ultrasound. The predictive values of IL-13, TGF-β1, and periostin methods were compared by receiver-operating characteristic (ROC) analysis and the area under the curve (AUC). Results. Increased levels of IL-13, TGF-β1, and periostin were noted in the AHF group than in the control and CAD groups ( p < 0.001 ); the CAD group showed higher levels of IL-13, TGF-β1, and periostin than the control group ( p < 0.001 ). Based on the NYHA classification, there were 33 cases with grade II, 28 cases with grade III, and 22 cases with grade IV among 83 CAD patients with HF. It was found that the serum levels of IL-13, TGF-β1, and periostin were higher in the AHF-IV group than in the AHF-III and AHF-II groups ( p < 0.001 ); these levels were also higher in the AHF-III group than in the AHF-II group ( p < 0.001 ). The periostin level was positively correlated with the levels of IL-13 (r = 0.458) and TGF-β1 (r = 0.569) in CAD patients with AHF. Besides, the serum levels of periostin (r = -0.425), IL-13 (r = -0.341), and TGF-β1 (r = -0.435) were negatively correlated with the LVEF of CAD patients with AHF, respectively. When IL-13, TGF-β1, and periostin levels were used to predict the presence of AHF in CAD patients in combination, the sensitivity and specificity were 75.9% and 90.38%, respectively, with the AUC of 0.906 (95% CI: 0.912–0.996). Conclusion. These data reveal that IL-13, TGF-β1, and periostin levels might be associated with the occurrence of AHF in CAD patients and their combination shows the predictive value for the presence of AHF in CAD patients.

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Section: Introductionmentioning

confidence: 99%

Circulating Levels of IL-13, TGF-β1, and Periostin as Potential Biomarker for Coronary Artery Disease with Acute Heart Failure

Qiu

Fengyi

Zhang

2021

Evidence-Based Complementary and Alternative Medicine

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“…Generoso [138] in cross-sectional analysis observed when adjusted with TG-level per 1-SD decrease in Total HDL-c, HDL 2 -c and HDL 3 -c and HDL 2 -c/HDL 3 -c ratios have no significant association with Ln(CAC + 1), having CAC > 0 vs CAC = 0, having CAC ≥ 100 vs CAC < 100 and ln(CAC), whereas adjustment with LDL-c didn t attenuated relations of Total HDL-c, HDL2-c and HDL3-c with either Ln(CAC + 1) or CAC > 0 vs CAC = 0.…”

Section: Cac-development With Progressing Risk Factorsmentioning

confidence: 99%

Subclinical cardiovascular disease and utility of coronary artery calcium score

Saydam¹

2021

IJC Heart & Vasculature

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“…Entretanto, essa associação não continuou significativa após ajuste para TG. 360 Esse estudo também avaliou as frações de HDLc e mostrou que elas não estavam associadas com calcificação na artéria coronária após ajuste para HDLc total. Além disso, o mesmo grupo demonstrou a associação entre HDLc e a espessura médio-intimal da carótida e ainda que tal associação é modificada pela presença de diabetes.…”

Section: Carga De Doençaunclassified

“…However, this association was no longer significant after adjustment for TG. 360 In addition, that study evaluated HDLc subfractions and demonstrated they were not associated with coronary artery calcification once adjusted for total HDLc. Furthermore, the same group showed the association between HDLc and carotid intima-media thickness, and its modification by the presence of diabetes.…”

Section: Attributable Riskmentioning

confidence: 99%