High-density lipoprotein cholesterol, monthly variation and association with cardiovascular risk factors in 1000 forty-year-old Dutch citizens

Gent, C.M. van; Voort, H. Van Der; Hessel, L. W.

doi:10.1016/0009-8981(78)90163-8

Cited by 36 publications

(12 citation statements)

References 7 publications

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“…The female smokers with no additional or only one additional risk factor, and the male smokers exhibiting exactly one risk factor, showed HDL apolipoprotein A-I values lower than those of non-smokers and smokers. No statistical difference was evident, however, between male non-smokers and smokers in the subgroup exhibiting no additional risk factors, or between non-smokers and smokers of both sexes with (5,6,(9)(10)(11)(12)(13)(14). However, our study was not able to establish any significant differences between the HDL cholesterol values for moderate (<20/day) and heavy (>20/ day) smokers, among either men or women.…”

Section: The Effect Of Smoking On Serum Level Of Apolipoprotein A-1contrasting

confidence: 85%

“…However, our study was not able to establish any significant differences between the HDL cholesterol values for moderate (<20/day) and heavy (>20/ day) smokers, among either men or women. The negative effect of cigarette smoking becomes more apparent when considered in conjunction with other factors influencing HDL cholesterol level, such äs alcohol consumption (8,12,14), use of oral contraceptives (9,11,14), or physical exercise (7,17).…”

Section: The Effect Of Smoking On Serum Level Of Apolipoprotein A-1mentioning

confidence: 99%

“…It has been demonstrated in various epidemiological studies that cigarette smokers have lower HDL cholesterol levels than non-smokers or ex-smokers (5)(6)(7)(8)(9)(10)(11)(12)(13)(14). On the other hand, there has been little research to date on the potential effects of other components of HDL (e. g. apolipoprotein A-I, apolipoprotein A-II, phosphatidyl choline, sphingomyelin).…”

Section: Introductionmentioning

confidence: 99%

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The Effects of Cigarette Smoking on Serum Levels of HDL Cholesterol and HDL Apolipoprotein A-I. Findings of a prospective epidemiological study on employees of several companies in Westphalia, West Germany

Assmann¹,

Schulte²,

Schriewer³

1984

Clinical Chemistry and Laboratory Medicine

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Summary:In preventive studies of Company employees in Westphalia, HDL cholesterol was measured in the sera of 4933 men and 2365 women, äs well äs HDL apolipoprotein A-I in the sera of 3509 men and 1648 women. Three subgroups were compared: non-smokers = persons who have never smoked; ex-smokers = persons who do not smoke ät present but did in the past; smokers = persons who sinoke cigarettes at present. Mean values for HDL cholesterol and for HDL apolipoprotein A-I were significantly lower in smokers than in non-smokers or in ex-smokers, while there were no differences between the last two groups. These differences appeared in both sexes but were more pronounced in women than in men. To answer the question whether the observed differences are caused by the consumption of cigarettes by itself or whether they are caused by the presence of othef risk factors, further subgroups were compared to assess the influence of the risk factors obesity, hypertension, hypercholesterolaemia, hyperglycaemia and hyperuricaemia. It was found that -regardless of the presence of no, one, two or more risk factors -the frequency of probands with low HDL cholesterpl values (<0.907 mmöl/1 (men); < 1.166 mmol/1 (women)) was about 10% higher in smokers than in non-smokers or ex-smokers. Subgroups based on the number of risk factors did not exhibit the same clear distribution for apolipoprotein A-I values äs were seen for HDL cholesterol. The results are interpreted in the light of the existing literature. Einfluß des Zigarettenrauchens auf die Konzentration von HDL-Cholesterin und HDL-Apolipoprotein A-I im Blutserum -Ergebnisse der prospektiven epidemiologischen Studie bei Betriebsangehörigen in Westfalen

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Section: The Effect Of Smoking On Serum Level Of Apolipoprotein A-1contrasting

confidence: 85%

Section: The Effect Of Smoking On Serum Level Of Apolipoprotein A-1mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The Effects of Cigarette Smoking on Serum Levels of HDL Cholesterol and HDL Apolipoprotein A-I. Findings of a prospective epidemiological study on employees of several companies in Westphalia, West Germany

Assmann¹,

Schulte²,

Schriewer³

1984

Clinical Chemistry and Laboratory Medicine

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“…Because of the significant relation between 25-OHD 3 and apo A-I and HDL-C, we hypothesize that the known seasonal variation of 25-OHD 3 19 could also explain the seasonal variations previously found in HDL-C concentrations. 20 Because this last study 20 and the present survey only evaluated a part of the year, extrapolation to the whole year remains to be investigated. On the other hand, serum 25-OHD 3 levels demonstrated no significant independent correlation with total serum cholesterol and apo B levels.…”

Section: Discussionmentioning

confidence: 94%

Relation between 25-hydroxyvitamin D3, apolipoprotein A-I, and high density lipoprotein cholesterol.

Auwerx

Bouillon

Kesteloot

1992

Arterioscler Thromb

104

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In a survey of cardiovascular risk factors in 185 men and 173 women of a Belgian population group, an independent and highly significant positive correlation was found between the serum concentrations of 25-hydroxyvitamin D 3 and apolipoprotein A-I (p< 0.001 in both sexes). 25-Hydroxyvitamin D 3 also showed a positive correlation with high density lipoprotein cholesterol levels (p<0.05 in men and p< 0.005 in women). This relation was independent of a possible effect of 25-hydroxy vitamin D 3 on serum calcium. Taking the biological variation of 25-hydroxyvitamin D 3 levels (±2 SD=25 ng/ml) into account, these findings could explain variations in the levels of apolipoprotein A-I of 15 mg/100 ml and of high density lipoprotein cholesterol of 4 mg/100 ml. ( I n industrialized Western countries, coronary heart disease (CHD) accounts for more deaths than any other disease. 1 Hypercholesterolemia and elevated levels of low density lipoprotein cholesterol in particular are linked to this high cardiovascular mortality, whereas high density lipoprotein cholesterol (HDL-C) appears to be inversely related to CHD incidence. 2 Delineating the factors that influence concentrations of the lipoproteins and their various apolipoprotein constituents is, therefore, of primary importance.Most 3 " 8 but not all 9 -12 clinical studies suggest a hypercholesterolemic and hence atherogenic effect of supplements of vitamin D 3 . Others report that vitamin D 3 produces a form of atherosclerosis (or vitamin D 3 sclerosis) typified by diffuse fibroelastic thickening of the arterial wall with no evidence of lipid deposition. 3 Calcification, smooth muscle cell degeneration, and other forms of arterial damage may also contribute to vitamin D-induced injury to the arterial wall. Moreover, calcium antagonists appear to protect against atherosclerosis, suggesting a role for calcium in the development of atherosclerotic lesions. 13 The purpose of our study was to examine, as part of a population survey, the interrelation between serum 25-hydroxyvitamin D 3 (25-OHD 3 ) levels on the one hand and the serum concentration of total cholesterol, HDL-C, and the apolipoproteins A-I (apo A-I) and B (apo B) on the other hand.

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“…[52] Interestingly, a significant seasonal variation in plasma levels cholesterol with higher values in winter has been reported in many studies. [53][54][55][56][57][58] in a Lipid Research Clinics Coronary Primary Prevention Trial Placebo Group study [59] showed significant seasonal cycles, characterized by wintertime peaks in plasma levels of total cholesterol (TOT-C) and low-density lipoprotein cholesterol (LDL-C) (mean changes 7.4 and 6.4 mg/dL respectively), but no variation for triglycerides. A similar temporal pattern was confirmed in an elderly population [60] and in young, healthy subjects.…”

Section: Serum Cholesterol Levelmentioning

confidence: 99%

Winter Hypertension : Potential Mechanisms

Fares¹

2013

IJHS

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Abstract:Hypertension exhibits a winter peak and summer trough in countries both north and south of the equator. A variety of explanations have been proposed to account for the seasonal nature of hypertension. It is likely that this reflects seasonal variations in risk factors. Seasonal variations have been demonstrated in a number of risk factors may play essential roles for seasonality of hypertension such as noradrenalin, catecholamine and vasopressin, vitamin D, and serum cholesterol. However, a number of studies have also suggested a direct effect of environmental temperature and physical activity on blood pressure. This paper was design to review the available evidence on seasonal variations in hypertension and possible explanations for them.

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High-density lipoprotein cholesterol, monthly variation and association with cardiovascular risk factors in 1000 forty-year-old Dutch citizens

Cited by 36 publications

References 7 publications

The Effects of Cigarette Smoking on Serum Levels of HDL Cholesterol and HDL Apolipoprotein A-I. Findings of a prospective epidemiological study on employees of several companies in Westphalia, West Germany

The Effects of Cigarette Smoking on Serum Levels of HDL Cholesterol and HDL Apolipoprotein A-I. Findings of a prospective epidemiological study on employees of several companies in Westphalia, West Germany

Relation between 25-hydroxyvitamin D3, apolipoprotein A-I, and high density lipoprotein cholesterol.

Winter Hypertension : Potential Mechanisms

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