High‐density lipoprotein and homocysteine levels correlate inversely in preeclamptic women in northern Nigeria

VanderJagt, Dorothy J.; Patel, Rina J.; El-Nafaty, Aliyu Usman; Melah, George S.; Crossey, Michael J.; Glew, Robert H.

doi:10.1111/j.1600-0412.2004.00513.x

Cited by 48 publications

(33 citation statements)

References 36 publications

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“…[19] However, it is worth mentioning a few previous studies, which have not mentioned any differences in lipid parameters in both groups. [2021]…”

Section: Discussionmentioning

confidence: 99%

Maternal serum lipids in women with pre-eclampsia

Siddiqui¹

2014

Ann Med Health Sci Res

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Background:Evidence of increased oxidative stress due to endothelial dysfunction in pre-eclampsia has been well-established. Increase in the oxidative stress is associated with abnormal lipid profile.Aim:The aim of the study is to compare serum lipids in pre-eclamptic women and healthy pregnant women.Subjects and Methods:In this case-control study, blood samples were collected from 40 pregnant females diagnosed as pre-eclampsia and 80 normal pregnant females at the Department of Obstetrics and Gynecology at King Abdulaziz Medical City, Riyadh, Kingdom of Saudi Arabia between February 2009 and January 2010. We evaluated serum levels of total cholesterol, low-density lipoprotein and high-density lipoprotein cholesterol and triglyceride in women with pre-eclampsia and those of women with normal pregnancies. Data was analyzed using SPSS for Windows (version 17.0, SPSS Inc., Chicago, Illinois, USA). The data is presented descriptively and test for significance was done using the student t-test for continous data.Results:Women with pre-eclampsia exhibited higher serum triglyceride levels compared with normal pregnant women (P < 0.01). Other measured serum lipids did not differ significantly in the two groups.Conclusion:We recommend that any pregnant female with higher serum triglyceride concentrations may be further investigated for pre-eclampsia. Further large scale multicenter studies are required to establish the use of measuring serum triglyceride levels to screen the pregnant females for pre-eclampsia.

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“…[19] However, it is worth mentioning a few previous studies, which have not mentioned any differences in lipid parameters in both groups. [2021]…”

Section: Discussionmentioning

confidence: 99%

Maternal serum lipids in women with pre-eclampsia

Siddiqui¹

2014

Ann Med Health Sci Res

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“…Pre-eclampsia and eclampsia are among the most serious complications of pregnancy in Nigeria (6). Despite the volume of knowledge on pre-eclampsia and eclampsia, studies have continued on a daily basis to unravel the roles and contributions of different pathologic mechanisms implicated.…”

Section: Introductionmentioning

confidence: 99%

Free Radical Attack on Membrane Lipid and Antioxidant Vitamins in the Course of Pre-Eclamptic Pregnancy

Atiba¹,

Abbiyesuku²,

Niran-Atiba³

et al. 2014

Ethiop J Health Sci

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BackgroundDespite the volume of knowledge and daily reports on pre-eclampsia, its pathogenesis is still yet to be ascertained. Oxidative stress (oxidant (free radical) in excess of antioxidant) injury is one of the recently suggested pathogenetic mechanisms. This study, however, was designed to determine second and third trimesters of plasma malondialdehyde (product of free radical attack on membrane lipid) and vitamins C and E in pre-eclamptic Nigerian women.Subjects and MethodsA Total of 100 subjects, each for pre-eclamptic, apparently normal and non-pregnant women qualified for the study. Venous blood samples were taken in the second and third trimesters of pregnancy and at the point of contact for non-pregnant women. Variables were analyzed using SPSS version 16, taking level of significance to be 0.05.ResultsPlasma malondialdehyde in the third trimester of normal pregnancy (2.03±0.71µmol/l) was found to be significantly higher than the one in the second trimester (1.65±0.62µmol/l) (p<0.0001). For pre-eclamptic subjects, the malondialdehyde in the third trimester (3.13±0.61µmol/l) was also higher than the malondialdehyde in the second trimester (3.00±1.21µmol/l). The mean vitamin C values for subjects with normal pregnancy were similar in the second and third trimesters (38.25±19.66 vs. 38.66±19.40; p=0.882). For subjects with pre-eclampsia, the mean Vit C values were also similar in the 2nd and 3rd trimesters (35.05±18.37 vs. 37.20±24.44µmol/l; p=0.175). Mean vitamin E values in the second and third trimesters were also similar for subjects with normal pregnancy (28.62±13.85 vs. 28.50±13.35µmol/l; p=0.950). A similar finding was observed in pre-eclamptic subjects (25.09±12.79 vs. 28.00±14.83µmol/l; p=0.067).ConclusionThere was an increased product of membrane lipid attack (malondialdehyde) with no change in plasma levels of vitamins C and E as pregnancy advances into the third trimester of both normal and pre-eclamptic pregnancies. Antioxidant vitamins may not be useful in stopping the progression of free radical attack on membrane lipid to control pre-eclampsia.

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“…Maternal cholesterol is essential for both the hormonal and physical changes of early pregnancy. Gestational disorders such as pre-eclampsia and gestational diabetes, as well as maternal alcohol consumption, have been associated with lipoprotein changes [17]. Alterations in placental cholesterol concentrations have been associated with changes in placental transport functions during gestation.…”

Section: Discussionmentioning

confidence: 99%

The value of maternal serum progesterone and cholesterol levels and cervical transvaginal gray-scale histogram in predicting preterm birth in high-risk women

Sanad

El-Rab

Ahmed³

et al. 2013

Evidence Based Womenʼs Health Journal

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BackgroundPreterm labor (PTL) is a challenging gynecological problem that is accountable for high rates of perinatal mortality and morbidity. Low maternal serum cholesterol and progesterone levels are associated with preterm birth. Measurement of cervical length, funneling, and consistency are essential in screening for PTL. ObjectiveThe aim of the study was to show a correlation between maternal serum progesterone and cholesterol levels and cervical transvaginal gray-scale histogram at 20-25 weeks in the prediction of preterm birth in high-risk women. Patients and methodsThe study included 100 patients at high risk for PTL attending Minia Maternity University Hospital. Levels of progesterone and cholesterol were analyzed and a cervical transvaginal histogram to determine cervical glandular/stromal ratio was performed for all patients at 20-25 weeks of gestation. Results PTL occurred in 30 of 100 women. Increased incidence of spontaneous PTL was seen in patients with a short cervix and increased funneling. Serum progesterone was significantly (P = 0.001) lower in women who delivered preterm (80.6 ± 27.5) compared with women who delivered at term (116.1 ± 15.8). Also, serum cholesterol was significantly (P = 0.001) lower in women who delivered preterm (156.6 ± 35.4) than in women who delivered at term (185.6 ± 42.3). Glandular/stromal ratio was significantly lower (Po0.001) in women who delivered preterm (0.31 ± 0.04) than in those who delivered at term (0.98 ± 0.02). Conclusion Glandular/stromal ratio, serum progesterone and cholesterol levels, and transvaginal ultrasound findings can predict PTL in high-risk women. They can also be used for prevention of PTL.

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High‐density lipoprotein and homocysteine levels correlate inversely in preeclamptic women in northern Nigeria

Abstract: These results show that preeclampsia/eclampsia is associated with increased tHcy levels and that HDL levels are depressed in Nigerian women with this hypertensive, pregnancy associated disorder.

Cited by 48 publications

References 36 publications

Maternal serum lipids in women with pre-eclampsia

Maternal serum lipids in women with pre-eclampsia

Free Radical Attack on Membrane Lipid and Antioxidant Vitamins in the Course of Pre-Eclamptic Pregnancy

The value of maternal serum progesterone and cholesterol levels and cervical transvaginal gray-scale histogram in predicting preterm birth in high-risk women

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