High coffee intake is associated with lower grade nonalcoholic fatty liver disease: the role of peripheral antioxidant activity

Gutiérrez-Grobe, Ylse; Chávez-Tapia, Norberto C.; Sánchez-Valle, Vicente; Gavilanes-Espinar, Juan G; Ponciano-Rodríguez, Guadalupe; Uribe, Misael; Méndez-Sánchez, Nahúm

doi:10.1016/s1665-2681(19)30931-7

Cited by 74 publications

(60 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…By multiple regression analysis, coffee use was inversely associated with the degree of “bright liver,” while insulin resistance and obesity were directly associated with increased likelihood and severity of BLS on ultrasound . A case–control study from Mexico also found similar protective effects of coffee consumption against NAFLD as assessed by ultrasonography (Table ). The limitations of these studies are the insensitivity of ultrasound for minor grade of steatosis and possibly for established cirrhosis when steatosis may be resolved.…”

Section: Relationship Between Coffee Consumption and Nafld In Communimentioning

confidence: 81%

“…Similarly, others report little or no significant difference in catalase (0.2 ± 0.7 vs 0.3 ± 0.7 nM/min/mL) levels, superoxide dismutase (4.7 ± 2.1 vs 5.4 ± 3.4 U/mL), or thiobarbituric acid‐reactive substances (3.9 ± 1.5 vs 4.0 ± 1.8 μM/mL) between NAFLD and controls. Hence, while coffee intake has a protective effect against severity of NAFLD, the weight of evidence (albeit, currently incomplete) is that coffee's positive effects are unlikely to be attributable to any differences in antioxidant variables …”

Section: Mechanisms By Which Coffee May Reduce Severity Of Nafldmentioning

confidence: 99%

See 1 more Smart Citation

Coffee and non‐alcoholic fatty liver disease: Brewing evidence for hepatoprotection?

Chen

Teoh

Chitturi

et al. 2014

J of Gastro and Hepatol

View full text Add to dashboard Cite

Coffee is one of the most popular beverages in the world. Several studies consistently show that coffee drinkers with chronic liver disease have a reduced risk of cirrhosis and a lower incidence of hepatocellular carcinoma regardless of primary etiology. With the increasing prevalence of non-alcoholic fatty liver disease (NAFLD) worldwide, there is renewed interest in the effect of coffee intake on NAFLD severity and positive clinical outcomes. This review gives an overview of growing epidemiological and clinical evidence which indicate that coffee consumption reduces severity of NAFLD. These studies vary in methodology, and potential confounding factors have not always been completely excluded. However, it does appear that coffee, and particular components other than caffeine, reduce NAFLD prevalence and inflammation of non-alcoholic steatohepatitis. Several possible mechanisms underlying coffee's hepatoprotective effects in NAFLD include antioxidative, anti-inflammatory, and antifibrotic effects, while a chemopreventive effect against hepatocarcinogenesis seems likely. The so-far limited data supporting such effects will be discussed, and the need for further study is highlighted.

show abstract

Section: Relationship Between Coffee Consumption and Nafld In Communimentioning

confidence: 81%

Section: Mechanisms By Which Coffee May Reduce Severity Of Nafldmentioning

confidence: 99%

Coffee and non‐alcoholic fatty liver disease: Brewing evidence for hepatoprotection?

Chen

Teoh

Chitturi

et al. 2014

J of Gastro and Hepatol

View full text Add to dashboard Cite

show abstract

“…There are only a few publications investigating the associations between coffee and/or caffeine consumption, and NAFLD; two of these studies incorporated hepatic histologic data . In a study of patients with biopsy‐proven NASH, Molloy et al .…”

Section: Discussionmentioning

confidence: 99%

Coffee consumption in NAFLD patients with lower insulin resistance is associated with lower risk of severe fibrosis

Bambha

Wilson

Ünalp

et al. 2013

Liver International

View full text Add to dashboard Cite

Background Coffee has inverse relationships with both type 2 diabetes and hepatic fibrosis in patients with nonalcoholic fatty liver disease (NAFLD). Aim Relationships were explored between coffee intake and insulin resistance (IR) with respect to NAFLD histologic severity. Methods We analyzed data from 782 adults (≥18 years) in the Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN) from 2004–2008. IR was assessed using the HOMA-IR. We modeled associations between coffee intake and NAFLD histologic severity using multiple logistic regression and interactions between coffee and IR on NAFLD histology were explored. Results Among 782 participants, 38% (n=295) were men, 12% (n=97) were Latino, mean age (±standard deviation) was 48±12 years. Median BMI was 33.5 kg/m2 [interquartile range, 29.7–38.3] and median HOMA-IR was 4.3 [2.7–7.2]. Diabetes was present in 24% (n=189). NASH was present in 79% (n=616), and 25% (n=199) had advanced fibrosis. The frequency of coffee intake (cups/day, cpd) was as follows: 0 cpd, n=230 (29%); <1 cpd, n=219 (28%); 1 -<2 cpd, n=116 (15%); ≥2 cpd, n=217 (28%). The effect of coffee on fibrosis varied with degree of IR (interaction p=0.001). Coffee consumers with less IR, defined as HOMA-IR<4.3, had a lower odds of advanced fibrosis (OR=0.64; 95% CI, [0.46–0.88], p=0.001). There was no protective effect of coffee on advanced fibrosis among individuals with higher HOMA-IR (OR=1.06, 95% CI [0.87–1.28], p=0.6). Conclusions Coffee intake is inversely associated with advanced fibrosis among NAFLD patients with lower HOMA-IR. Our findings warrant further investigation given the worldwide ubiquity of coffee intake.

show abstract

“…Diets high in saturated fats or high fructose corn syrup may cause NAFLD, and minimizing these substances may be beneficial . High intake of coffee or oral supplementation of cysteine‐rich whey protein has been demonstrated to reduce hepatic steatosis in NAFLD …”

Section: Treatment Of Nonalcoholic Fatty Liver Diseasementioning

confidence: 99%

Nonalcoholic fatty liver disease in patients with psoriasis: a consequence of systemic inflammatory burden?

Prussick

Miele

2018

Br J Dermatol

View full text Add to dashboard Cite

Summary Patients with psoriasis are at an increased risk for nonalcoholic fatty liver disease (NAFLD) compared with the general population. However, the pathophysiology underlying this comorbidity and elucidation of effective treatment strategies are unclear. This review provides insights into the possible role of chronic, low‐grade inflammation in the pathogenesis of NAFLD in patients with psoriasis. Both conditions are associated with increased levels of proinflammatory adipokines (such as tumour necrosis factor‐α and interleukin‐6) and hepatokines, and decreased levels of adiponectin, an anti‐inflammatory adipokine. This imbalance in inflammatory mediators could result in insulin resistance and, thereby, facilitate the occurrence and progression of NAFLD in a multistep manner. All patients with psoriasis should, therefore, be considered candidates for NAFLD screening and managed accordingly. Given the common aetiology of inflammation between these conditions, it is hypothesized that biological therapies for psoriasis may attenuate the systemic inflammatory process and progression of NAFLD in patients with psoriasis.

show abstract

High coffee intake is associated with lower grade nonalcoholic fatty liver disease: the role of peripheral antioxidant activity

Cited by 74 publications

References 18 publications

Coffee and non‐alcoholic fatty liver disease: Brewing evidence for hepatoprotection?

Coffee and non‐alcoholic fatty liver disease: Brewing evidence for hepatoprotection?

Coffee consumption in NAFLD patients with lower insulin resistance is associated with lower risk of severe fibrosis

Nonalcoholic fatty liver disease in patients with psoriasis: a consequence of systemic inflammatory burden?

Contact Info

Product

Resources

About