Coffee consumption in <scp>NAFLD</scp> patients with lower insulin resistance is associated with lower risk of severe fibrosis

Bambha, Kiran; Wilson, Laura; Ünalp, Aynur; Loomba, Rohit; Neuschwander‐Tetri, Brent A.; Brunt, Elizabeth M.; Bass, Nathan M.

doi:10.1111/liv.12379

Cited by 89 publications

(95 citation statements)

References 48 publications

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“…Study (first author and year) Total caffeine intake (mg/day) Birerdinc et al [2012] Total caffeine intake (mg/day) Catalano et al [2010] Espresso coffee intake (cups/day) Gutierrez-Grobe et al [2012] Total caffeine intake (mg/day) Bambha et al [2014] Coffee (unspecified) intake (cups/day) Anty et al [2012] Total caffeine intake (g/week), caffeine from espresso, regular coffee, tea and chocolate or soda (g/week) Molloy et al [2012] Total caffeine or regular coffee caffeine intake (mg/day) significant benefit remains unclear, it is clear that the potential benefit of coffee needs to be further investigated.…”

Section: Discussionmentioning

confidence: 99%

Association between caffeine consumption and nonalcoholic fatty liver disease: a systemic review and meta-analysis

Shen

Rodriguez

Shiani

et al. 2015

Therap Adv Gastroenterol

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Objectives: Caffeine consumption is reported to be associated with reduced hepatic fibrosis in patients with chronic liver diseases. We performed a systematic review and meta-analysis to assess the association between caffeine consumption and prevalence or hepatic fibrosis of nonalcoholic fatty liver disease (NAFLD) in observational studies. Methods:We searched the literature of all languages from PubMed, EMBASE, and the Cochrane library from 1 January 1980 through 10 January 2015. Total caffeine consumption was defined as the daily intake of caffeine (mg/day) from all caffeine-containing products. Combined and subgroup analyses stratified by study designs, study locations, and type of caffeine intake were performed. Results: Four cross-sectional and two case control studies with a total of 20,064 subjects were included in the meta-analysis. Among these, three studies with 18,990 subjects were included in the analysis for prevalence of NAFLD while the other three studies with 1074 subjects were for hepatic fibrosis. Total caffeine consumption (mg/day) was not significantly associated with either the prevalence [pooled mean difference (MD) 2.36; 95% confidence interval (CI) −35.92 to 40.64] or hepatic fibrosis (higher versus lower stages; pooled MD −39.95; 95% CI −132.72 to 52.82) of NAFLD. Subgroup analyses stratified by study designs and locations were also not significant. However, after stratifying by type of caffeine intake, regular coffee caffeine intake (mg/day) was significantly associated with reduced hepatic fibrosis of NAFLD (pooled MD −91.35; 95% CI −139.42 to −43.27; n = 2 studies). Conclusion: Although total caffeine intake is not associated with the prevalence or hepatic fibrosis of NAFLD, regular coffee caffeine consumption may significantly reduce hepatic fibrosis in patients with NAFLD.

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Section: Discussionmentioning

confidence: 99%

Association between caffeine consumption and nonalcoholic fatty liver disease: a systemic review and meta-analysis

Shen

Rodriguez

Shiani

et al. 2015

Therap Adv Gastroenterol

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“…In addition, lifestyle factors such as consumption of soft drinks [15] and coffee [16] as well as physical activity [17] that might have disease-modifying properties, have not been investigated as potential confounders.…”

Section: Introductionmentioning

confidence: 99%

Low to moderate lifetime alcohol consumption is associated with less advanced stages of fibrosis in non-alcoholic fatty liver disease

Hagström

Nasr

Ekstedt

et al. 2016

Scandinavian Journal of Gastroenterology

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“…The studies based on ultrasound data have provided evidence that coffee intake is inversely related to the degree of liver steatosis. Likewise, the studies utilizing serum markers of fibrosis and histology have demonstrated coffee consumption inversely related to fibrosis in patients with NAFLD [53,72,73]. Molloy et al also reported a relation between coffee intake and histopathology of liver [53].…”

Section: The Mechanism Of Coffee's Hepatoprotective Effectmentioning

confidence: 97%

Multiple Beneficial effects Associated with Coffee Consumption on Human Liver

Saleem¹,

Latif²

2017

J Hepatol Gastroint Dis

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Coffee is widely consumed beverage in the world. Incidence of chronic liver disease decreases with intake of coffee.The main objective of this study is to elucidate the hepatoprotective as well as chemo protective effect of coffee consumption in relation to previous published data. Prospective cohort studies based on relationship between coffee intake and ultimate effects on liver cancer have drawn various conclusions. Coffee's beneficial effects in various disease states have been demonstrated in variety of studies. Studies have provided data regarding effects of coffee in hot as well as in cold state. Level of blood cholesterol, following filtration, is affected by the coffee components. Among the components of coffee, caffeine played the significant role in reducing the level of ALT in coffee consumers as compared with non-coffee consumers. Coffee intake is associated with cardiovascular events and hypertension risks. However, intake of coffee has been found to be inversely related to the level of serum enzymes like gamma-glutamyltransferase, and alanine aminotransferase when studies relating to coffee effect on liver were performed in different countries. Moreover, the data based on epidemiological analysis, clearly suggested that liver cirrhosis had inverse relationship with coffee consumption; however, the results obtained were not sufficient to demonstrate that coffee may have hepatoprotective effect in liver injury. There is emerging evidence revealing that consumption of coffee has been associated with reduction of risks of various types of cancers. The emerging data on coffee consumption has revealed that it has beneficial effects in colorectal, pancreatic, and pharyngeal as well as in liver cancer. A systematic review was performed regarding association of coffee consumption and effect of coffee intake on liver diseases like hepatocellular carcinoma (HCC), viral hepatitis, cirrhosis and nonalcoholic fatty liver disease (NAFLD). Coffee consumption, in dose dependent manner, was found to improve the level of serum gamma-glutamyltransferase, alanine aminotransferase and aspartate aminotransferase in individuals which were found to be at risk of liver diseases. Anticancer effect of coffee on liver is achieved by induction as well as inhibition of specific enzymes. The patients with history of chronic liver disease who consume coffee, were reported to be at a reduced risk of liver to be cirrhotic, and a decreased mortality rate was observed in cirrhosis patients, as well as a decreased rate of development of Hepatocellular carcinoma was observed. In individuals with history of chronic hepatitis C, coffee intake was found to be associated with enhanced virologic reaction to antiviral drug therapy. Furthermore, coffee intake was reported to be inversely associated with the severeness of steatohepatitis in individuals with non-alcoholic fatty liver disorder. Therefore, in patients with chronic liver disease, coffee consumption on daily basis should be persuaded.

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Coffee consumption in NAFLD patients with lower insulin resistance is associated with lower risk of severe fibrosis

Cited by 89 publications

References 48 publications

Association between caffeine consumption and nonalcoholic fatty liver disease: a systemic review and meta-analysis

Association between caffeine consumption and nonalcoholic fatty liver disease: a systemic review and meta-analysis

Low to moderate lifetime alcohol consumption is associated with less advanced stages of fibrosis in non-alcoholic fatty liver disease

Multiple Beneficial effects Associated with Coffee Consumption on Human Liver

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