High Brachial-Ankle Pulse Wave Velocity Is an Independent Predictor of the Presence of Coronary Artery Disease in Men

Imanishi, Ryo; Seto, Shinji; Toda, Genji; Yoshida, Masanori; Ohtsuru, Akira; Koide, Yuji; Baba, Takeshi; Yano, Katsusuke

doi:10.1291/hypres.27.71

Cited by 142 publications

(122 citation statements)

References 29 publications

(27 reference statements)

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“…Its validity, reproducibility and high correlation with aortic PWV obtained by a catheter tip manometer have been previously reported. 17 Values of baPWV have been found to correlate with carotid-femoral PWV values 18 and have also been shown to be significantly associated with the presence and extent of atherosclerotic vascular diseases, 19,20 cardiovascular risk factors in healthy adolescents, 21 microalbuminuria and QT interval prolongation in general subjects, 22,23 and cardiovascular events in patients with heart failure 24 and acute coronary syndrome. 25 Moreover, baPWV has been found to be a marker of the efficacy of therapies intended to achieve regression of arterial stiffness.…”

Section: Introductionmentioning

confidence: 99%

Brachial-ankle pulse wave velocity as a risk stratification index for the short-term prognosis of type 2 diabetic patients with coronary artery disease

et al. 2010

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, the Shinken Database Study GroupThe incidence of diabetes is increasing, and the disease has become an important predictor of prognosis in patients with coronary artery disease (CAD), although adverse events often occur without warning. Thus, risk stratification of diabetic CAD patients is important for secondary prevention. This study tests the hypothesis that brachial-ankle pulse wave velocity (baPWV), a marker for arterial stiffness obtained by simple and noninvasive automated devices, can be a risk stratification index to predict prognosis in diabetic patients with CAD. The prognosis of CAD patients with diabetes in the Shinken Database cohort study was investigated by dividing patients into two groups based on baPWV measurements. The composite endpoint was death, nonfatal myocardial infarction, repeat revascularization or readmission for heart failure. Data were available on 564 CAD patients, with a median follow-up of 25.4 months. Of these patients, 191 had type 2 diabetes. The higher baPWV among diabetic patients was defined as a median baPWV of 1730 cm s -1 or more. The 3-year Kaplan-Meier estimates of event-free survival were 72.8% in diabetic patients with lower baPWV and 51.3% in those with higher baPWV, respectively (P¼0.031). Multivariate analysis revealed that a higher baPWV was independently associated with poorer short-term prognosis (hazard ratio, 1.97; 95% confidence interval, 1.01-3.84) in diabetic CAD patients. In conclusion, baPWV, a marker for arterial stiffness, can be a risk stratification index for short-term prognosis in clinical practice, suggesting the need for further aggressive treatment and strict follow-up in CAD patients with diabetes and higher baPWV.

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Section: Introductionmentioning

confidence: 99%

Brachial-ankle pulse wave velocity as a risk stratification index for the short-term prognosis of type 2 diabetic patients with coronary artery disease

et al. 2010

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“…7 Brachial-ankle PWV (baPWV) can be measured with a simple and noninvasive device that estimates arterial stiffness. Cross-sectional studies have reported an association between high baPWV and prevalence of cardiovascular risk factors, 11,12 presence of coronary artery disease in male patients, 13 presence of cerebrovascular disease in asymptomatic community-dwelling older persons 14 and in hypertensive patients aged 50 years or older. 15 However, there have been few longitudinal reports about the relationship between baPWV and mortality.…”

Section: Introductionmentioning

confidence: 99%

Association between brachial–ankle pulse wave velocity and 3-year mortality in community-dwelling older adults

et al. 2010

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With aging, arterial stiffness increases and results in cardiovascular diseases. Recently, high brachial-ankle pulse wave velocity (baPWV), measured using a new noninvasive device to estimate arterial stiffness, was reported to be associated with the prevalence of cardiovascular diseases. The purpose of this study was to clarify the association between baPWV with 3-year mortality in community-dwelling older adults and to determine the cutoff value of baPWV in terms of mortality. A total of 530 subjects aged 65 years or older (men/women, 207:323; mean age, 76 years) participated. They were dichotomized by the median value of baPWV. Within 3 years, 30 deaths occurred, including 11 cardiovascular deaths. The high-baPWV group had a higher incidence of total deaths (high-baPWV group vs. low-baPWV group, 8.3 vs. 3.0%, respectively) and cardiovascular deaths (high-baPWV group vs. lowbaPWV group, 3.8 vs. 0.4%, respectively). A high-baPWV level was associated with an increased risk of 3-year total mortality after adjustment for age, sex and systolic blood pressure (hazard ratio for high baPWV vs. low baPWV¼2.98, 95% CI¼1.25-7.07) and with an increased risk of 3-year cardiovascular mortality (hazard ratio for high baPWV vs. low baPWV¼10.01, 95% CI¼1.21-82.49). A receiver-operating characteristic curve showed that the optimal cutoff value of baPWV for total mortality was 19.63 m s À1 , and for cardiovascular mortality it was 19.63 m s À1 . This study provides a preliminary finding that assessment of arterial stiffness by baPWV might be a useful method to predict mortality risk in community-dwelling older adults. Large longitudinal studies for extended periods of time are necessary to confirm the association.

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“…LVH has been considered to be an intermediate phenotype of hypertensive heart diseases ( 9 ). Recently arterial stiffness was suggested to be an independent predictor of the presence of coronary artery disease ( 10 ), and arterial stiffness was associated with LVH in hemodialysis patients ( 11 ). Therefore, arterial stiffness was considered to be an intermediate phenotype of hypertensive complications.…”

Section: Introductionmentioning

confidence: 99%

Genetic Influences of .BETA.-Adrenoceptor Polymorphisms on Arterial Functional Changes and Cardiac Remodeling in Hypertensive Patients

et al. 2006

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High Brachial-Ankle Pulse Wave Velocity Is an Independent Predictor of the Presence of Coronary Artery Disease in Men

Cited by 142 publications

References 29 publications

Brachial-ankle pulse wave velocity as a risk stratification index for the short-term prognosis of type 2 diabetic patients with coronary artery disease

Brachial-ankle pulse wave velocity as a risk stratification index for the short-term prognosis of type 2 diabetic patients with coronary artery disease

Association between brachial–ankle pulse wave velocity and 3-year mortality in community-dwelling older adults

Genetic Influences of .BETA.-Adrenoceptor Polymorphisms on Arterial Functional Changes and Cardiac Remodeling in Hypertensive Patients

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