High blood pressure, antihypertensive medication and lung function in a general adult population

Schnabel, Eva; Karrasch, Stefan; Schulz, Holger; Gläser, Sven; Meisinger, Christa; Heier, Margit; Peters, Annette; Wichmann, H‐Erich; Behr, Jürgen; Huber, Rudolf M.; Heinrich, Joachim

doi:10.1186/1465-9921-12-50

Cited by 25 publications

(26 citation statements)

References 24 publications

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“…These findings are in line with previous observations, although the mechanism is still unclear. Schnabel et al 23 reported an association between both high blood pressure and the use of beta-blockers with impaired lung function. We did not investigate the use of antihypertensive agents, and cannot precisely explain the mechanism underlying the association between the systolic blood pressure and lung function in men.…”

Section: Discussionmentioning

confidence: 99%

Visceral adipose tissue level, as estimated by the bioimpedance analysis method, is associated with impaired lung function

Inomata¹,

Kawagishi²,

Taka³

et al. 2011

J of Diabetes Invest

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Aims/Introduction: It has been reported that metabolic syndrome is associated with impaired lung function, and abdominal obesity is regarded as the most important determinant of this association. We evaluated the association between a component of metabolic syndrome, indices of body composition, including the total adipose tissue content, lean bodyweight and visceral adipose tissue content, as assessed by bioimpedance analysis, and lung function.Materials and Methods: A total of 516 participants responded to our questionnaire to determine the smoking status and history of past diseases. Waist circumference, height, bodyweight, percent forced expiratory volume in 1 s (%FEV1) and percent forced vital capacity (%FVC) were measured. Fasting blood samples were obtained to determine the serum levels of high‐density lipoprotein and triglyceride, and also the blood glucose. The body composition, including the total adipose tissue content and lean bodyweight, was measured, and the visceral adipose tissue content was estimated as the visceral adipose tissue level, by the bioimpedance analysis method.Results: Waist circumference, estimated visceral adipose tissue level and blood pressure were significantly associated with the %FEV1, and the serum high‐density lipoprotein cholesterol was significantly associated with the %FVC in men, after adjustment for age, smoking history, and past histories of bronchial asthma and ischemic heart disease. However, this association was not detected in women.Conclusions: We found an association between the visceral adipose tissue level as estimated by the bioimpedance analysis method and lung function. (J Diabetes Invest, doi: 10.1111/j.2040‐1124.2011.00189.x, 2011)

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Section: Discussionmentioning

confidence: 99%

Visceral adipose tissue level, as estimated by the bioimpedance analysis method, is associated with impaired lung function

Inomata¹,

Kawagishi²,

Taka³

et al. 2011

J of Diabetes Invest

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“…Moreover, both pulmonary disease and systemic blood pressure are associated with biomass fuel use, yet the interaction between pulmonary function and systemic blood pressure in the setting of biomass fuel use has not been adequately characterized. While several large cohort studies have described an association between reduced lung function with blood pressure and arterial elasticity, it remains unclear whether cardiovascular disease from HAP occurs with concomitant reduced lung function 12–15 . We sought to determine the association between daily biomass fuel use with systemic blood pressure, prehypertension and hypertension in a population-based cohort of adults in Puno, Peru and if lung function, as measured by spirometry, was an effect modifier of the relationship between daily biomass fuel use and systemic blood pressure.…”

Section: Introductionmentioning

confidence: 99%

Relationship Between Daily Exposure to Biomass Fuel Smoke and Blood Pressure in High-Altitude Peru

et al. 2015

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Household air pollution from biomass fuel use affects three billion people worldwide; however, few studies have examined the relationship between biomass fuel use and blood pressure. We sought to determine if daily biomass fuel use was associated with elevated blood pressure in high altitude Peru and if this relationship was affected by lung function. We analyzed baseline information from a population-based cohort study of adults aged ≥35 years in Puno, Peru. Daily biomass fuel use was self-reported. We used multivariable regression models to examine the relationship between daily exposure to biomass fuel smoke and blood pressure outcomes. Interactions with sex and quartiles of forced vital capacity (FVC) were conducted to evaluate for effect modification. Data from 1004 individuals (mean age 55.3 years, 51.7% female) were included. We found an association between biomass fuel use with both prehypertension (adjusted relative risk ratio 5.0, 95% CI 2.6 to 9.9) and hypertension (adjusted relative risk ratio 3.5, 95% CI 1.7 to 7.0). Biomass fuel users had a higher SBP (7.01 mmHg, 95% CI 4.4 to 9.6) and a higher DBP (5.9 mmHg, 95% CI 4.2 to 7.6) when compared to nonusers. We did not find interaction effects between daily biomass fuel use and sex or percent predicted FVC for either SBP or DBP. Biomass fuel use was associated with an increased risk of hypertension and higher blood pressure in Peru. Reducing exposure to household air pollution from biomass fuel use represents an opportunity for cardiovascular prevention.

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“…Several recent studies have shown similar results of the relationship between lung function and hypertension after adjusting for potential confounders [9,12,[27][28]. Schnabel et al [9] reported that high blood pressure was associated with reduced lung function (for both % predicted FVC and FEV 1 ) in general adult population adjusting for gender and other covariates. In contrast to our study, Margretardottir et al [12] found that significantly stronger inverse association between FVC and hypertension in men than in women.…”

Section: Discussionmentioning

confidence: 77%

“…Numerous studies [1][2][3][4][5][6][7] have demonstrated that blood pressure is a risk factor for future cardiovascular diseases. Also these studies have shown that persons with lower pulmonary function indicators, forced expiratory volume in one second (FEV 1 ) [2,[4][5][8][9], forced vital capacity (FVC) [6][7][8][9] and FEV 1 /FVC ratio [3] have a higher risk for developing cardiovascular diseases including hypertension. There may be several possible pathophysiological mechanisms for these associations including impaired left ventricular performance and cigarette smoking.…”

Section: Introductionmentioning

confidence: 99%

Relationship between Lung Function and Hypertension among Rural Canadians using Fractional Polynomials

Karunanayake

Rennie²,

Pahwa

et al. 2012

Sri Lankan J App Stats

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Studies have shown that persons with lower pulmonary function have a higher risk for developing cardiovascular diseases including hypertension. The objectives of this paper are to examine: (i) the relationship between lung function and hypertension; and (ii) the correct functional forms of the continuous predictors of hypertension using fractional polynomials. This analysis was based on data from a cross-sectional community study of 1,834 adult subjects aged 18-79 years conducted in 2003 in Humboldt, Saskatchewan, Canada. Clinical measurements were made during a clinic visit, and other information was collected from a questionnaire. Logistic regression analysis was conducted to determine associations between hypertension and lung function measurements. Multivariate fractional polynomial logistic regression model was used to preserve the continuous nature of the predictor variables. There was an expected significant difference between men and women in values for FVC and FEV 1. We observed that the ordinary logistic regression model and fractional polynomial model gave the same functional form when stratified by gender. The data suggest an increasing risk of hypertension with decreasing FVC and FEV 1 values. After adjusting for potential risk factors including age, body mass index, parental history of hypertension and smoking, there was increased risk of hypertension among women with low FVC [OR adj : 0.73 (95% CI: 0.56, 0.95)]. We did not see this association for men [OR adj : 1.10 (95% CI: 0.90, 1.33)]. We observed that the risk of hypertension increases with decreasing FVC for women after adjusting for potential risk factors.

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High blood pressure, antihypertensive medication and lung function in a general adult population

Cited by 25 publications

References 24 publications

Visceral adipose tissue level, as estimated by the bioimpedance analysis method, is associated with impaired lung function

Visceral adipose tissue level, as estimated by the bioimpedance analysis method, is associated with impaired lung function

Relationship Between Daily Exposure to Biomass Fuel Smoke and Blood Pressure in High-Altitude Peru

Relationship between Lung Function and Hypertension among Rural Canadians using Fractional Polynomials

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