High Birth Weight Is Associated With Obesity and Increased Carotid Wall Thickness in Young Adults

Skilton, Michael R.; Siitonen, Niina; Würtz, Peter; Viikari, Jorma; Juonala, Markus; Seppälä, Ilkka; Laitinen, Tomi; Lehtimäki, Terho; Taittonen, Leena; Kähönen, Mika; Celermajer, David S.; Raitakari, Olli T.

doi:10.1161/atvbaha.113.302934

Cited by 93 publications

(84 citation statements)

References 28 publications

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“…Child's BAZ had no Risk of overweight and obesity in childhood were more common in cases with higher birthweight and increased appetite. In a Finnish study, babies born large for gestational age were more likely found to be obese young adults 21 . Maternal responsiveness studies found that mothers were more responsive to child hunger than fullness clues 22 .…”

Section: Discussionmentioning

confidence: 97%

Parental perception and child's nutritional status

Yalçin¹,

Serdaroğlu²,

Ince³

2016

Turk J Pediatr

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Childhood obesity is a health hazard increasing worldwide. Preschool period which is under supervision of parents is a critical period to detect overweight and take precautions. We studied the factors affecting parental estimation of their preschool child's weight. Three hundred sixty seven mothers completed questionnaires consisting of child's and parents' anthropometric measurements, parents' assessment of their child's and their own weight status, and general information about their lifestyle. Mothers also chose their wish for current and future body image of their child from child drawings representing percentiles. Child body mass index-for-age z score (BAZ) was related to birth weight and child's appetite. BAZ was not related to child's gender, presence of chronic disease, family pattern, parental age, education or income. 43.1 % of mothers correctly assessed child's BAZ verbally. Maternal verbal estimation was correlated with maternal visual estimation, paternal verbal estimation and child's BAZ. Mothers' wish for future figure of the child was not related to child's BAZ, but showed correlation with mothers' wish for current figure of the child. Mother's correct perception of her child's weight was found to be high, consistent with her spouse and related to child's BAZ.

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Section: Discussionmentioning

confidence: 97%

Parental perception and child's nutritional status

Yalçin¹,

Serdaroğlu²,

Ince³

2016

Turk J Pediatr

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“…9 Evidence linking excessive fetal growth and a large for gestational age (LGA) birth weight with cardiovascular risk and events is not that well established. [9][10][11][12] Abnormalities in fetal growth are associated with maternal disease and pregnancy disorders, including preeclampsia and diabetes mellitus.…”

Section: See Editorial By Gardiner See Clinical Perspectivementioning

confidence: 99%

Neonatal Arterial Morphology Is Related to Body Size in Abnormal Human Fetal Growth

Olander

Sundholm

Ojala

et al. 2016

Circ: Cardiovascular Imaging

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Background-Restriction in fetal growth is associated with cardiovascular disease in adulthood. It is unclear whether abnormal intrauterine growth influences arterial morphology during the fetal or neonatal stage. The objective was to study the regional arterial morphology with respect to gestational age and abnormal fetal body size. Methods and Results-We studied body anthropometrics and arterial morphology and physiology in 174 neonates born between 31 and 42 weeks of gestation, including neonates with birth weights appropriate, small, and large for age, with very high resolution vascular ultrasound (35-55 MHz). In simple linear regressions, parameters of body size (body weight, body surface area, and organ circumference) and gestational age were statistically significantly associated with common carotid, brachial, femoral arterial parameters (lumen diameter [LD], wall layer thickness [intima-media thickness and intima-media-adventitia thickness], and carotid artery wall stress [CAWS]). Male sex was statistically significantly associated with LD and CAWS. In multiple linear regression models, body size, gestational age, and sex explained a large proportion of the arterial variance (R 2 range, 0.37-0.47 for LD; 0.09-0.35 for intima-media thickness; 0.21-0.41 for intima-media-adventitia thickness; and 0.23 for CAWS; all models P<0.001). Arterial wall layer thickness, LDs, and CAWS were independently and strongly predicted by body size, and no effect of maternal disease was observed when added to the models. Gestational age and male sex were also independently but more weakly associated with arterial LDs and CAWS (P<0.01), but not with arterial wall layers. Conclusions-These results indicate that the intrauterine growth of fetal arterial LD and wall layer thickness are primarily attributed to body growth overall. LD and CAWS show weaker association with gestational age and sex. (Circ Cardiovasc Imaging. 2016;9:e004657.

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“…Alterations in the regulation of nutrients in prenatal life may be responsible for the onset of short or long-term endocrine-metabolic disorders such as postnatal insulin resistance, diabetes type 1, obesity and disorders in puberty [7,30]. This is the pathophysiological basis for numerous and detailed clinical studies on adults [31][32][33]. These studies start to highlight the mechanisms that are able to establish a link between the various critical moments of the embryo-fetal development, which are also represented by a rapid cell proliferation, and the eventual diseases of postnatal life.…”

Section: Endocrine and Paracrine Factorsmentioning

confidence: 99%

Pregnancy, embryo-fetal development and nutrition: physiology around fetal programming

Musumeci¹,

Castrogiovanni²,

Trovato³

et al. 2015

J Histol Histopathol

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The purpose of this brief narrative review is to highlight the role of nutrition during the gestation period. We focused on the possible effects of imbalance of some nutrients in normal course of pregnancy and embryonic development. We discussed about changes in nutritional and/or hormonal embryonic microenvironment, which represent the basis of a phenomenon known as "fetal programming". We strongly believe that the understanding of these events can be a valuable tool in order to prevent the onset of disorders and diseases in postnatal life.

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High Birth Weight Is Associated With Obesity and Increased Carotid Wall Thickness in Young Adults

Cited by 93 publications

References 28 publications

Parental perception and child's nutritional status

Parental perception and child's nutritional status

Neonatal Arterial Morphology Is Related to Body Size in Abnormal Human Fetal Growth

Pregnancy, embryo-fetal development and nutrition: physiology around fetal programming

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