High and long-term antibacterial activity against Escherichia coli via synergy between the antibiotic penicillin G and its carrier ZnAl layered double hydroxide

Li, Mengxue; Sultanbawa, Yasmina; Xu, Zhi Ping; Gu, Wenyi; Chen, Wei-Yu; Liu, Jianyong; Qian, Guangren

doi:10.1016/j.colsurfb.2018.11.035

Cited by 46 publications

(21 citation statements)

References 42 publications

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“…A suitable method, leading to materials with different structure, surface physicochemical and textural properties, can show better performance in antimicrobial activity. It is known that the method of preparation plays an important role in the antimicrobial performance of ZnAl hydroxides [54,55,56]. The reaction conditions of this study were as follows: zinc chloride and aluminum at a ratio of 5:2 were dissolved in 200 mL of distilled water, at a final pH of 10, under nitrogen atmosphere with magnetic stirring at 60 °C and finally, the precipitate was dried at 40 °C.…”

Section: Resultsmentioning

confidence: 99%

Optimization of ZnAl/Chitosan Supra-Nano Hybrid Preparation as Efficient Antibacterial Material

Gohi

Zeng

et al. 2019

IJMS

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The menace of antimicrobial resistance continues to increase and hence the need to discover new antibiotics, especially alternative and effective sources such as hybrid organic-inorganic, organic-organic materials, and other combinations. In this study, an antimicrobial hybrid supra-nano material was prepared by the bi-titration synthesis method of chitosan (CS) and ZnAl layered double hydroxide. Fourier-transform infrared spectrometer (FTIR), thermogravimetric and differential thermal gravimetric (TGA/DTG), ultraviolet-visible (UV-Vis), X-ray diffraction (XRD), and scanning electron microscopy (SEM) analyses indicated that the ZnAl/CS hybrid exhibited low crystallinity with high thermal stability. The results of ZnAl/CS characterization showed the characteristic properties of the individual components ZnAl and CS, indicating a successful preparation of the ZnAl/CS hybrid. The antibacterial tests revealed that the ZnAl/CS hybrid possessed an enhanced antimicrobial effect against both Escherichia coli (E. coli, MTCC 739) and Penicilliumcyclopium (P. cyclopium, AS 3.4513). Under the central composite design (CCD) of the response surface methodology (RSM) tool, the parameters of the hybrid synthesis reaction were optimized and the result obtained was as follows: reaction pH was 11.3, reagent Zn/Al ratio was 3.27, and chitosan concentration was 1.07 g/L. After optimization, it was found that the antibacterial activity of ZnAl/CS was strengthened against E. coli as evidenced by a widening of the inhibition zone of about 41.6%. The antibacterial activity of ZnAl/CS was mainly due to the reactivation of the antibacterial activity of CS associated with the release of Zn2+ and Al3+ metal ions in addition to ZnO, Al2O3, and ZnAl2O4 compounds resulting from the method of preparation.

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Section: Resultsmentioning

confidence: 99%

Optimization of ZnAl/Chitosan Supra-Nano Hybrid Preparation as Efficient Antibacterial Material

Gohi

Zeng

et al. 2019

IJMS

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“…In the meantime, the released Zn +2 ions from Zn-Al LDHs had an antibacterial ability by signicantly improving the antibacterial effect of PNG. 58 Jin et al intercalated an anticancer drug 5-uorouracil/ cyclodextrin (5-FU/CMCD) into a Zn-Al LDH. The drug release time was prolonged and controlled by the hydrophobic environment of the CMCD cavity and by the durability of the LDH.…”

Section: Antibacterial Properties Of Ldhsmentioning

confidence: 99%

Layered double hydroxide-based nanocomposite scaffolds in tissue engineering applications

et al. 2021

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“…Among many uses, such as catalysts [3,4], magnetic materials [5] and polymer fillers [6], LDHs stand out for their application as vehicles for drug storage and delivery [7,8], mainly due to their in vitro and in vivo biocompatibility [9][10][11][12][13][14] and to the possibility to modify drug release kinetics. Anti-inflammatories [15,16] and bactericidal [17][18][19] species are examples of organic guests, already loaded into LDH, that can promote a faster and painless wound healing process. Briefly, such process is characterized by a sequence of four complex, overlapped and regulated phases: hemostasis, inflammation, proliferation and remodeling [20].…”

Section: Introductionmentioning

confidence: 99%

Polymer/Iron-Based Layered Double Hydroxides as Multifunctional Wound Dressings

et al. 2020

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This work presents the development of multifunctional therapeutic membranes based on a high-performance block copolymer scaffold formed by polyether (PE) and polyamide (PA) units (known as PEBA) and layered double hydroxide (LDH) biomaterials, with the aim to study their uses as wound dressings. Two LDH layer compositions were employed containing Mg2+ or Zn2+, Fe3+ and Al3+ cations, intercalated with chloride anions, abbreviated as Mg-Cl or Zn-Cl, or intercalated with naproxenate (NAP) anions, abbreviated as Mg-NAP or Zn-NAP. Membranes were structurally and physically characterized, and the in vitro drug release kinetics and cytotoxicity assessed. PEBA-loading NaNAP salt particles were also prepared for comparison. Intercalated NAP anions improved LDH–polymer interaction, resulting in membranes with greater mechanical performance compared to the polymer only or to the membranes containing the Cl-LDHs. Drug release (in saline solution) was sustained for at least 8 h for all samples and release kinetics could be modulated: a slower, an intermediate and a faster NAP release were observed from membranes containing Zn-NAP, NaNAP and Mg-NAP particles, respectively. In general, cell viability was higher in the presence of Mg-LDH and the membranes presented improved performance in comparison with the powdered samples. PEBA containing Mg-NAP sample stood out among all membranes in all the evaluated aspects, thus being considered a great candidate for application as multifunctional therapeutic dressings.

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High and long-term antibacterial activity against Escherichia coli via synergy between the antibiotic penicillin G and its carrier ZnAl layered double hydroxide

Abstract: High and long-term antibacterial activity against Escherichia coli via synergy between the antibiotic penicillin G and its carrier ZnAl layered double hydroxide

Cited by 46 publications

References 42 publications

Optimization of ZnAl/Chitosan Supra-Nano Hybrid Preparation as Efficient Antibacterial Material

Optimization of ZnAl/Chitosan Supra-Nano Hybrid Preparation as Efficient Antibacterial Material

Layered double hydroxide-based nanocomposite scaffolds in tissue engineering applications

Polymer/Iron-Based Layered Double Hydroxides as Multifunctional Wound Dressings

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