High altitude arterialised capillary earlobe blood gas measurement using the Abbott i-STAT

Lewis, Clifton; Malein, Will; Chesner, I. M.; Clarke, Sarah B

doi:10.1136/jramc-2017-000902

Cited by 10 publications

(5 citation statements)

References 8 publications

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“…In remote areas that lack the resources for drawing blood from the radial or femoral artery or a blood gas analyzer, the collection of arterialized earlobe blood and use of simple portable instrument such as Abbott i-stat, can also be considered, which have certain application value according to the literature (1,14). This study has some limitations.…”

Section: Discussionmentioning

confidence: 99%

Blood gas analysis of healthy people in Diqing Tibetan Autonomous Prefecture in Yunnan Province

Li¹,

Zhang²,

Zhang

2021

Ann Palliat Med

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Background: To investigate the reference value of blood gas analysis and related factors in healthy adults in Diqing Tibetan Autonomous Prefecture in Yunnan Province. Methods: From August 24, 2018 to August 11, 2020, healthy people between the ages of 18 and 70 years were observed at the Physical Examination Center of People's Hospital of Diqing Tibetan Autonomous Prefecture in Yunnan province. Participant information and clinical characteristics were collected. Blood gas analyzer was used to measure PH value, arterial partial oxygen pressure (PaO 2 ), arterial partial pressure of carbon dioxide (PaCO 2 ), arterial oxygen saturation (SaO 2 ), acidity (pH), actual bicarbonate (AB) and residual base (BE). The participants' basic and blood gas indicator data were analyzed, and the blood gas reference values and related factors were analyzed using chi-squared tests, Mann-Whitney-Wilcoxon Test, and Spearman's correlation analysis. Results: A total of 1,218 eligible health examination participants were included. They had an average age of 40 [31-47] years, and males accounted for 51.0%. In terms of blood gas reference values, the average pH value was moderate, and the values of PaO 2 , SaO 2 , PaCO 2 , AB, and BE were low. PaO 2 was basically matched with the estimated value of the domestic model formula. These indexes were found to be correlated with social demographic characteristics such as sex, age, and smoking history. Conclusions: The correlations between the indexes and social demographic characteristics may be helpful in the prediction of blood gas analysis results in clinical practice. For men, middle-aged and elderly people, or adults with a history of active smoking/biofuel exposure, blood gas PaO 2 and PaCO 2 should be monitored to facilitate the early intervention of respiratory failure. The PaO 2 data basically matched the estimated values of the domestic model formula, suggesting that other regions in the Prefecture could use comprehensive epidemiological data and model methods to guide clinical work.

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Section: Discussionmentioning

confidence: 99%

Blood gas analysis of healthy people in Diqing Tibetan Autonomous Prefecture in Yunnan Province

Li¹,

Zhang²,

Zhang

2021

Ann Palliat Med

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“…Venous blood samples were taken daily, centrifuged, and the sera were stored alongside urine samples. Daily arterialized ear lobe partial pressure of oxygen (pO 2 ) measurements were obtained using an Abbott i-STAT (Lewis et al, 2018 ), and twice daily Lake Louise (LL) AMS scores were recorded.…”

Section: Methodsmentioning

confidence: 99%

Urinary Alpha-1-Acid Glycoprotein Is a Sensitive Marker of Glomerular Protein Leakage at Altitude

Talks

Bradwell

Delamere

et al. 2018

High Altitude Medicine & Biology

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Talks, Ben J., Susie B. Bradwell, John Delamere, Will Rayner, Alex Clarke, Chris T. Lewis, Owen D. Thomas, and Arthur R. Bradwell. Urinary alpha-1-acid glycoprotein is a sensitive marker of glomerular protein leakage at altitude. High Alt Med Biol. 19:295–298, 2018.—Proteinuria is an established feature of ascent to altitude and may be caused by a loss of negative charges on glomerular capillary walls (GCWs). To test this hypothesis, we measured two similar sized but oppositely charged proteins in urine: negatively charged alpha-1-acid glycoprotein (α1-AGP, 41–43 kDa) and positively charged dimeric lambda free light chains (λ-FLCs, 50 kDa). Twenty-four-hour urinary leakage was compared with albumin, a 66 kDa negatively charged protein. We studied 23 individuals (ages 23–78 years, male = 17) at baseline (140 m) and daily during an expedition to 5035 m. The results showed a significant increase in median urinary leakage of α1-AGP (p < 0.0001; 6.85-fold) and albumin (p = 0.0006; 1.65-fold) with ascent to altitude, but no significant increase in leakage of λ-FLCs (p = 0.39; 1.14-fold). α1-AGP correlated with the daily ascent profile (p = 0.0026) and partial pressure of oxygen (p = 0.01), whereas albumin showed no correlation (p = 0.19). Urinary α1-AGP was a more sensitive marker of altitude proteinuria than urinary albumin and λ-FLCs, and supported the possibility of loss of GCW negative charges at altitude.

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“…Blood gas monitoring was performed with earlobe arterialized capillary blood and analyzed using the I‐STAT ® System (Abbott Laboratories). The method of capillary sampling has been described previously 7 : The inferior aspect of the earlobe was cleaned with an alcohol solution and dried in the air. Nicotinate paste was applied to the earlobe for at least 10 min to induce capillary vasodilation.…”

Section: Methodsmentioning

confidence: 99%

Cardiopulmonary response to high‐altitude mountaineering in lung transplant recipients—The Jebel Toubkal experience

Schrutka

Slama

Muehlbacher

et al. 2021

Scandinavian Med Sci Sports

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Objectives Only a small proportion of lung transplant recipients achieve a physical status comparable to healthy individuals in the long term. It is reasonable to hypothesize that the necessary cardiopulmonary adaptation required for strenuous physical exercise may be impaired. Exposure to high altitude provides an optimal platform to study the physiological cardiopulmonary adaptation in lung transplant recipients under aerobic conditions. To gain a deeper understanding, 14 healthy lung transplant recipients and healthcare professionals climbed the highest peak in North Africa (Mount Jebel Toubkal; 4167 m) in September 2019. Methods Monitoring included daily assessment of vital signs, repeated transthoracic echocardiography, pulmonary function tests, and capillary blood sampling throughout the expedition. Results Eleven out of fourteen lung transplant recipients reached the summit. All recipients showed a stable lung function and vital parameters and physiological adaptation of blood gases. Similar results were found in healthy controls. Lung transplant recipients showed worse results in the 6‐minute walk test at low and high altitude compared to controls (day 1: 662 m vs. 725 m, p < 0.001, day 5: 656 m vs. 700 m, p = 0.033) and a lack of contractile adaptation of right ventricular function with increasing altitude as measured by tricuspid plane systolic excursion on echocardiography (day 2: 22 mm vs. 24 mm, p = 0.202, day 5: 23 mm vs. 26 mm, p = 0.035). Conclusions Strenuous exercise in healthy lung transplant recipients is safe. However, the poorer cardiopulmonary performance in the 6‐minute walk test and the lack of right ventricular cardiac adaptation may indicate underlying autonomic dysregulation.

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High altitude arterialised capillary earlobe blood gas measurement using the Abbott i-STAT

Cited by 10 publications

References 8 publications

Blood gas analysis of healthy people in Diqing Tibetan Autonomous Prefecture in Yunnan Province

Blood gas analysis of healthy people in Diqing Tibetan Autonomous Prefecture in Yunnan Province

Urinary Alpha-1-Acid Glycoprotein Is a Sensitive Marker of Glomerular Protein Leakage at Altitude

Cardiopulmonary response to high‐altitude mountaineering in lung transplant recipients—The Jebel Toubkal experience

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