High-Affinity DNA Nanomatrix: A Platform Technology for Synergistic Drug Delivery and Photothermal Therapy

Abstract

With the advent of nucleosome/nucleotide intercalating drugs, DNA-based nanocarriers have recently gained impetus. However, most of the newly proposed DNA nanosystems are rather complex, thereby having low scalability and translatability. In this study, we propose a simple DNA nanomatrix core encapsulated within a chitosan shell, which is expected to enhance the encapsulation efficiency of intercalating drugs. This has been demonstrated using proflavine hemisulfate (PfHS), a model intercalating agent that shows improved ROS generation, among other anticancerous properties. The release of the drug from the nanomatrix is triggered by providing a heat trigger using IR-792 perchlorate, a known NIR photothermal sensitizer.

Light‐absorbing copolymers of polyimides as efficient photothermal materials for solar water evaporation

“…[3,4] Photothermal materials can absorb solar light and convert solar energy to thermal energy. [5][6][7][8][9][10] Being capable of directly and efficiently utilizing solar energy, photothermal materials have demonstrated promising prospects in water treatment, [11][12][13][14] photothermal diagnosis, [15][16][17][18] and photothermal power generation. [19][20][21][22] An ideal photothermal material should efficiently collect light across the solar spectrum and convert sunlight to heat without any other energy transformation (e.g., reradiation).…”

PLGA nanoparticle loaded with antioxidants and photosensitizer for ROS shock mediated phototherapy of triple negative breast cancer

“…In another study, IR-792 PC was loaded along with the DSPE-PEG (2000) that forms a self-assembled nano particles that are decorated with the macrophage cell membrane to cross the blood brain barrier for the treatment of Glioblastoma [18]. IR-792 PC was also encapsulated in a chitosan nanocarrier, increasing the release of the drug by NIR activation to provide a synergistic effect along with proflavin hemisulfate for a potential anticancer effect [19]. To the best of our knowledge, the use of IR-792 PC in the PDT along with antioxidants was not reported.…”