High activity of rituximab combined with cladribine and cyclophosphamide in a patient with pulmonary lymphomatoid granulomatosis and bone marrow involvement

Robak, T; Kordek, Radzisław; Urbańska-Ryś, H; Robak, Paweł; Bartkowiak, Jacek; Chudobiński, Cezary; Chojnowski, Krzysztof

doi:10.1080/10428190600564753

Cited by 15 publications

(11 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Respiratory symptoms, mainly cough and dyspnea, with systemic symptoms of fever, weight loss and sweating were present at diagnosis [2,3,9] . Common radiological findings are multiple poorly defined excavated nodular densities or masses which are bilateral and predominant in the lower lobes [9][10][11] .…”

Section: Discussionmentioning

confidence: 99%

“…Patients with grade I and II are treated with corticosteroids, while those with grade III are considered a subtype of diffuse large B cell lymphoma and treated clinically as such [8] . New therapeutic approaches such as rituximab, interferon-␣ 2b and autologous hematopoietic stem cell transplantation have been attempted [3,13] .…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, rituximab has been recognized as a new treatment option for LYG over the last few years. It has been used alone or combined with conventional chemotherapy [3,14,17] . The patient with LYG treated with CHOP in combination with rituximab was still in complete remission after 18 months of follow-up [18] .…”

Section: Discussionmentioning

confidence: 99%

“…However, the overall prognosis of LYG is poor and only less than 50% of cases survive more than 5 years [1,2] . Recently, cases treated with rituximab, an anti-CD20 monoclonal antibody, have been reported with variable responses [3,4] . Here, we present a 70-year-old male patient with pulmonary LYG successfully treated with rituximab combined with prednisolone, cyclophosphamide and vincristine.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

A Case of Pulmonary Lymphomatoid Granulomatosis Successfully Treated by Combination Chemotherapy with Rituximab

Jung

Sung²,

Lee³

et al. 2009

Chemotherapy

View full text Add to dashboard Cite

Lymphomatoid granulomatosis (LYG) is a rare angiocentric and angiodestructive lymphoproliferative disease characterized by Epstein-Barr virus-positive B cells admixed with reactive T cells. LYG most commonly affects the lung but can also involve other extrapulmonary sites. Pulmonary LYG usually presents as multiple pulmonary nodules with rapid progression and excavation. It can mimic various infectious diseases, vasculitis or metastatic malignancy and is difficult to be diagnosed clinically. Standard treatment for LYG has not yet been established. Despite combination chemotherapy, the overall prognosis is poor. Recently, anti-CD20 monoclonal antibody, rituximab, has been used to treat LYG. We report the case of a 70-year-old male patient with pulmonary LYG, who showed rapid remission of the disease after combination chemotherapy with rituximab.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

A Case of Pulmonary Lymphomatoid Granulomatosis Successfully Treated by Combination Chemotherapy with Rituximab

Jung

Sung²,

Lee³

et al. 2009

Chemotherapy

View full text Add to dashboard Cite

show abstract

“…Bone marrow involvement, although rare in some of these entities, has been described [38,39]. The paucity of neoplastic cells and the presence of a polymorphic background, often rich in histiocytes and small reactive T cells, in all these entities, can pose a diagnostic challenge, especially, when reviewing BM biopsies.…”

Section: Discussionmentioning

confidence: 99%

Nodular pattern of bone marrow infiltration: frequent finding in immunosuppression-related EBV-associated large B-cell lymphomas

et al. 2009

View full text Add to dashboard Cite

Different patterns of bone marrow (BM) infiltration by diffuse large B cell lymphomas (DLBCL) have been described. A pure nodular pattern is uncommon, and the pathologic features, as well as the clinical correlates of DLBCL manifesting this pattern in the BM have not been well characterized. We evaluated BM biopsies involved by large B cell lymphomas diagnosed at our institute over an 11-year period to assess the morphology, phenotype, cytogenetic abnormalities, and clinical features of cases associated with a nodular pattern. A distinct nodular pattern of BM involvement was noted in 14 out of 55 (25%) cases. Although both EBV+ and EBV- DLBCL with this pattern were identified, a pure nodular pattern was significantly more common in EBV+ DLBCL compared to EBV- DLBCL (8/9, 89% versus 6/46, 13%; P = 0.00002). The majority of EBV+ DLBCL associated with a nodular pattern had distinctive morphologic features (polymorphic cellular infiltrate and pleomorphic cytology), and CD30 expression was more commonly observed in this group (P = 0.0163). All EBV+ DLBCL and two out of six (33%) EBV- DLBCL had nongerminal center phenotypes. No recurrent cytogenetic abnormalities were detected in either group. Importantly, all EBV+ DLBCL occurred in individuals with immune dysfunction (organ transplant recipients, HIV infection) or in those >50 years of age. Our study indicates a much higher predilection for EBV+ DLBCL to involve the marrow in a nodular pattern compared to EBV- cases and highlights similarities in the morphologic pattern of BM involvement by previously recognized subsets of immunodeficiency-related EBV + lymphomas and the newer entity of "EBV+ DLBCL of the elderly."

show abstract

From Cancer Mimicking Orphan Lung Disease to Orphan Thoracic Oncology

Girard¹,

Cottin²,

Cordier³

2014

Orphan Lung Diseases

View full text Add to dashboard Cite

High activity of rituximab combined with cladribine and cyclophosphamide in a patient with pulmonary lymphomatoid granulomatosis and bone marrow involvement

Cited by 15 publications

References 12 publications

A Case of Pulmonary Lymphomatoid Granulomatosis Successfully Treated by Combination Chemotherapy with Rituximab

A Case of Pulmonary Lymphomatoid Granulomatosis Successfully Treated by Combination Chemotherapy with Rituximab

Nodular pattern of bone marrow infiltration: frequent finding in immunosuppression-related EBV-associated large B-cell lymphomas

From Cancer Mimicking Orphan Lung Disease to Orphan Thoracic Oncology

Contact Info

Product

Resources

About