Hierarchical porous Mg2SiO4-CoFe2O4 nanomagnetic scaffold for bone cancer therapy and regeneration: Surface modification and in vitro studies

Bigham, Ashkan; Aghajanian, Amir Hamed; Saudi, Ahmad; Rafienia, Mohammad

doi:10.1016/j.msec.2019.110579

Cited by 49 publications

(28 citation statements)

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“…Porosity is one of the important parameters in bone tissue engineering that is necessary for cell penetration, nutrients and waste transfer, and angiogenesis 22 . Evaluation of the scaffolds here showed that the porosity percentage of fibers in the first layer was more than 80% and in the second and third layers were about 50% to 55% and 10% to 20%, respectively.…”

Section: Resultsmentioning

confidence: 71%

Electrospun captopril‐loadedPCL‐carbon quantum dots nanocomposite scaffold: Fabrication, characterization, and in vitro studies

Ghorghi

Rafienia

Nasirian

et al. 2020

Polymers for Advanced Techs

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Electrospinning as an effective and accessible method is known to yield scaffolds with desired physical, chemical, and biological properties for tissue engineering. In the present study, captopril (CP)-loaded polycaprolactone (PCL)/carbon quantum dots (CQDs) nanocomposite scaffolds were fabricated for bone tissue regeneration. The microstructure and hydrophilicity/hydrophobicity ratio of scaffolds were assessed by scanning electron microscopy and wettability test, respectively. The results showed that the presence of CQDs and CP in the scaffolds decreased the fiber diameter (1180 ± 281.5-345 ± 110 nm) and also it led to an increase in the surface hydrophilicity (137-0) of scaffolds. Evaluation of the scaffolds' functional groups was performed using Attenuated Total Reflectance-Fourier Transform Infrared spectroscopy. The ultimate tensile strength of scaffolds was in the range of 6.86 ± 0.00 to 22.09 ± 0.06 MPa. Distribution of CQDs in the scaffolds' fibers was investigated by transmission electron microscopy and fluorescent spectrometer. The cell viability, attachment, proliferation, and alkaline phosphatase (ALP) activity of scaffolds were assessed in vitro. Based on the overall results, the scaffold containing CQDs and CP led to a significant increase in the cells' proliferation and ALP activity. Therefore, the PCL/CQDs/CP is recommended as a potential nanocomposite scaffold for bone tissue regeneration.

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Section: Resultsmentioning

confidence: 71%

Electrospun captopril‐loadedPCL‐carbon quantum dots nanocomposite scaffold: Fabrication, characterization, and in vitro studies

Ghorghi

Rafienia

Nasirian

et al. 2020

Polymers for Advanced Techs

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“…The TEM micrograph of PCL/GT/GLN7% fibrous scaffold is indicated in Figure 2C, where the GLN nanoparticles are visible to be distributed through the fibers. It was previously reported that a uniform dispersion of bioceramic nanoparticles into the polymeric phase would lead to better mechanical properties and biocompatibility 18,34 …”

Section: Resultsmentioning

confidence: 99%

“…Ideally, a scaffold or membrane designed for bone tissue engineering should have a function and structure similar to a body tissue plus having appropriate physical, chemical, and biological properties. The architectural style of natural bone as a complex connective tissue comprises approximately 70% of mineral constituents, nearly 20% organic constituents, and 10% water 18,19 …”

Section: Introductionmentioning

confidence: 99%

A ternary nanocomposite fibrous scaffold composed of poly(ε‐caprolactone)/Gelatin/Gehlenite (Ca₂Al₂SiO₇): Physical, chemical, and biological properties in vitro

Baghbadorani

Bigham

Rafienia

et al. 2020

Polymers for Advanced Techs

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Scaffolds are regarded as 3D substrates providing an appropriate environment through which the cells attachment, proliferation, and differentiation rate can be accelerated; based on their application, these scaffolds must have certain characteristics like suitable mechanical properties and porosity, desired degradation rate, and cell compatibility. In the present study, a novel nanocomposite fibrous scaffold composed of poly(ε‐caprolactone) (PCL)/Gelatin (GT)/Gehlenite (GLN) nanoparticles was fabricated through electrospinning method. Different weight ratios of GLN nanoparticles in the fibrous scaffolds were added and optimized and a series of samples including PCL, PCL/GT, and PCL/GT/GLN scaffolds were constructed in order to reach a better comparison between the scaffolds. It turned out that 7% was the optimized GLN weight ratio to be included into the scaffolds without destroying the fibers structure. Different characterization techniques were applied to assess the physical and chemical properties of scaffolds. Moreover, the scaffolds' degradation rate, bioactivity potential, cell viability, attachment, DAPI and Alizarin staining, and ALP activity were assessed in vitro as well. The overall results indicate that the ternary scaffold (PCL/GT/GLN7%) has a promising potential for bone tissue regeneration.

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“…[ 1 ] Despite the self-healing ability of bone, there are some clinical challenges of bone injuries in the case of fractures, joint arthroplasties, and dental defects that interfere with the normal bone healing procedure, where autogenous and allogenous bone grafts cannot solve these problems. [ 2 3 4 ] Therefore, the treatment of large bone defects is an issue that remains a significant challenge for orthopedic surgeons. [ 2 ] To reform bone defects, bone grafts have been used regularly.…”

Section: Introductionmentioning

confidence: 99%

In vitro Studies of Polycaprolactone Nanofibrous Scaffolds Containing Novel Gehlenite Nanoparticles

et al. 2021

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Hierarchical porous Mg2SiO4-CoFe2O4 nanomagnetic scaffold for bone cancer therapy and regeneration: Surface modification and in vitro studies

Cited by 49 publications

References 50 publications

Electrospun captopril‐loadedPCL‐carbon quantum dots nanocomposite scaffold: Fabrication, characterization, and in vitro studies

Electrospun captopril‐loadedPCL‐carbon quantum dots nanocomposite scaffold: Fabrication, characterization, and in vitro studies

A ternary nanocomposite fibrous scaffold composed of poly(ε‐caprolactone)/Gelatin/Gehlenite (Ca₂Al₂SiO₇): Physical, chemical, and biological properties in vitro

In vitro Studies of Polycaprolactone Nanofibrous Scaffolds Containing Novel Gehlenite Nanoparticles

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Hierarchical porous Mg2SiO4-CoFe2O4 nanomagnetic scaffold for bone cancer therapy and regeneration: Surface modification and in vitro studies

Cited by 49 publications

References 50 publications

Electrospun captopril‐loadedPCL‐carbon quantum dots nanocomposite scaffold: Fabrication, characterization, and in vitro studies

Electrospun captopril‐loadedPCL‐carbon quantum dots nanocomposite scaffold: Fabrication, characterization, and in vitro studies

A ternary nanocomposite fibrous scaffold composed of poly(ε‐caprolactone)/Gelatin/Gehlenite (Ca2Al2SiO7): Physical, chemical, and biological properties in vitro

In vitro Studies of Polycaprolactone Nanofibrous Scaffolds Containing Novel Gehlenite Nanoparticles

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A ternary nanocomposite fibrous scaffold composed of poly(ε‐caprolactone)/Gelatin/Gehlenite (Ca₂Al₂SiO₇): Physical, chemical, and biological properties in vitro