“…More recently it became clear that beyond the aim of characterizing individual fiber bundles, the connectivity profile of the entire brain is of highest importance in neuroscience. Following the pioneering work based on chemical tracing of (Felleman and Van Essen, 1991) and others (Hilgetag and Kaiser, 2004;Hilgetag et al, 2000;Sporns and Zwi, 2004), similar connection matrices have been built from MRI tractography, either by constructing large-scale networks of 1000 nodes (Hagmann et al, 2007) or more anatomically based connection matrices (Gong et al, 2009(Gong et al, , 2008Iturria-Medina et al, 2007Li et al, 2009;Thottakara et al, 2006). Diffusionbased connectivity has also been used in some studies (Behrens and Johansen-Berg, 2005;Klein et al, 2007;Tomassini et al, 2007) to parcellate gray matter.…”