Hierarchical bioresponsive nanocarriers for codelivery of curcumin and doxorubicin

Lin, Jiantao; Ye, Qing-Bang; Yang, Qingjin; Wang, Guan-Hai

doi:10.1016/j.colsurfb.2019.04.023

Cited by 20 publications

(18 citation statements)

References 39 publications

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“…They take advantage of intracellular conditions and rely specifically on the presence of glutathione (GSH) with a high level of expression in cancer cells compared to normal cells [227]. For example, Lin et al [228] prepared pH and redox dual-stage responsive release of curcumin with Dox through specific cleavable PEGylation and hydrogel coating (crosslinked by disulfide bonds). The used MSNs were loaded with Dox, whereas the curcumin was encapsulated in a hydrogel coating.…”

Section: Redox-responsive Releasementioning

confidence: 99%

“…In further investigations, they found that the plausible mechanism contributing to anticancer effects is the generation of intracellular ROS and the induction of apoptosis. Lin et al [228] tailored a co-delivery system of Dox loaded into MSNs as the core and curcumin loaded into the polymeric coating shell. The results indicate the long duration of blood circulation due to the PEG shell, GSH-sensitive release effect for drugs, and high cellular uptake resulting in synergistic anticancer effects through enhanced apoptosis of Hela cells.…”

Section: Curcuminmentioning

confidence: 99%

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Delivery of Natural Agents by Means of Mesoporous Silica Nanospheres as a Promising Anticancer Strategy

AbouAitah

Łojkowski

2021

Pharmaceutics

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Natural prodrugs derived from different natural origins (e.g., medicinal plants, microbes, animals) have a long history in traditional medicine. They exhibit a broad range of pharmacological activities, including anticancer effects in vitro and in vivo. They have potential as safe, cost-effective treatments with few side effects, but are lacking in solubility, bioavailability, specific targeting and have short half-lives. These are barriers to clinical application. Nanomedicine has the potential to offer solutions to circumvent these limitations and allow the use of natural pro-drugs in cancer therapy. Mesoporous silica nanoparticles (MSNs) of various morphology have attracted considerable attention in the search for targeted drug delivery systems. MSNs are characterized by chemical stability, easy synthesis and functionalization, large surface area, tunable pore sizes and volumes, good biocompatibility, controlled drug release under different conditions, and high drug-loading capacity, enabling multifunctional purposes. In vivo pre-clinical evaluations, a significant majority of results indicate the safety profile of MSNs if they are synthesized in an optimized way. Here, we present an overview of synthesis methods, possible surface functionalization, cellular uptake, biodistribution, toxicity, loading strategies, delivery designs with controlled release, and cancer targeting and discuss the future of anticancer nanotechnology-based natural prodrug delivery systems.

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Section: Redox-responsive Releasementioning

confidence: 99%

Section: Curcuminmentioning

confidence: 99%

Delivery of Natural Agents by Means of Mesoporous Silica Nanospheres as a Promising Anticancer Strategy

AbouAitah

Łojkowski

2021

Pharmaceutics

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“…Smart nanomaterials (e.g., pH-sensitive and redox-sensitive nanoparticles) can be applied for targeted delivery of curcumin and DOX, to release their cargo in response to the tumor microenvironment. Besides, the surface of nanoparticles can be modified by receptors and ligands (such as hyaluronic acid and RGD) to promote accumulation in cancer cells (Figure 6) [222][223][224][225][226][227][228][229][230][231][232][233][234]. In Table 3, different nanocarriers applied for codelivery of curcumin and DOX are described.…”

Section: Codelivery Via Biological Nanovehiclesmentioning

confidence: 99%

Polychemotherapy with Curcumin and Doxorubicin via Biological Nanoplatforms: Enhancing Antitumor Activity

et al. 2020

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Doxorubicin (DOX) is a well-known chemotherapeutic agent extensively applied in the field of cancer therapy. However, similar to other chemotherapeutic agents such as cisplatin, paclitaxel, docetaxel, etoposide and oxaliplatin, cancer cells are able to obtain chemoresistance that limits DOX efficacy. In respect to dose-dependent side effect of DOX, enhancing its dosage is not recommended for effective cancer chemotherapy. Therefore, different strategies have been considered for reversing DOX resistance and diminishing its side effects. Phytochemical are potential candidates in this case due to their great pharmacological activities. Curcumin is a potential antitumor phytochemical isolated from Curcuma longa with capacity of suppressing cancer metastasis and proliferation and affecting molecular pathways. Experiments have demonstrated the potential of curcumin for inhibiting chemoresistance by downregulating oncogene pathways such as MMP-2, TGF-β, EMT, PI3K/Akt, NF-κB and AP-1. Furthermore, coadministration of curcumin and DOX potentiates apoptosis induction in cancer cells. In light of this, nanoplatforms have been employed for codelivery of curcumin and DOX. This results in promoting the bioavailability and internalization of the aforementioned active compounds in cancer cells and, consequently, enhancing their antitumor activity. Noteworthy, curcumin has been applied for reducing adverse effects of DOX on normal cells and tissues via reducing inflammation, oxidative stress and apoptosis. The current review highlights the anticancer mechanism, side effects and codelivery of curcumin and DOX via nanovehicles.

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“…Combined treatment of at least two biomolecules in chemotherapy has also obtained much attention from researchers, which is confirmed to be beneficial to kill tumor with reduced chemotherapeutic dosage, less side effects, and good prognosis 127 . A DOX/ p‐Cur (phosphorylated curcumin) co‐delivered hierarchical responsive nanocarrier was designed by encapsulating DOX into mesoporous silica nanoparticles (MSNs) and adding p‐Cur in the outside hydrogel coating layer 128 . Researchers found that drugs (DOX and p‐Cur) were released in sequence due to the pH‐responsive collapse of MSNs and the GSH‐triggered hydrogel coating (PEG) dissociation, outside in cancer tissue and inside of tumor cells, respectively.…”

Section: The Application Of Hydrogels In Localized Tumor Treatmentmentioning

confidence: 99%

Advances and trends of hydrogel therapy platform in localized tumor treatment: A review

Tan

Huang

et al. 2020

J Biomedical Materials Res

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Due to limitations of treatment and the stubbornness of infiltrative tumor cells, the outcome of conventional antitumor treatment is often compromised by a variety of factors, including severe side effects, unexpected recurrence, and massive tissue loss during the treatment. Hydrogel‐based therapy is becoming a promising option of cancer treatment, because of its controllability, biocompatibility, high drug loading, prolonged drug release, and specific stimuli‐sensitivity. Hydrogel‐based therapy has good malleability and can reach some areas that cannot be easily touched by surgeons. Furthermore, hydrogel can be used not only as a carrier for tumor treatment agents, but also as a scaffold for tissue repair. In this review, we presented the latest researches in hydrogel applications of localized tumor therapy and highlighted the recent progress of hydrogel‐based therapy in preventing postoperative tumor recurrence and improving tissue repair, thus proposing a new trend of hydrogel‐based technology in localized tumor therapy. And this review aims to provide a novel reference and inspire thoughts for a more accurate and individualized cancer treatment.

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Hierarchical bioresponsive nanocarriers for codelivery of curcumin and doxorubicin

Cited by 20 publications

References 39 publications

Delivery of Natural Agents by Means of Mesoporous Silica Nanospheres as a Promising Anticancer Strategy

Delivery of Natural Agents by Means of Mesoporous Silica Nanospheres as a Promising Anticancer Strategy

Polychemotherapy with Curcumin and Doxorubicin via Biological Nanoplatforms: Enhancing Antitumor Activity

Advances and trends of hydrogel therapy platform in localized tumor treatment: A review

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