Hierarchical Assembly of Nanodimensional Silver–Silver Oxide Physical Gels Controlling Nosocomial Infections

Abstract

Microbial infections originating from medical care facilities are raising serious concerns across the globe. Therefore, nanotechnology-derived nanostructures have been investigated and explored due to their promising characteristics. In view of this, silver-based antimicrobial hydrogels as an alternative to antibiotic-based creams could play a crucial role in combating such infections. Toward this goal, we report a simple method for the synthesis and assembly of silver nanoparticles in a biopolymer physical gel derived from Abroma augusta plant in imparting antimicrobial properties against nosocomial pathogens. Synthesized silver nanoparticles (diameter, 30 ± 10 nm) were uniformly distributed inside the hydrogel. Such synthesized hydrogel assembly of silver nanoparticles dispersed in the biopolymer matrix exhibited hemocompatibility and antimicrobial and antibiofilm characteristics against nosocomial pathogens. The developed hydrogel as a surface coating offers reduced hardness and modulus value, thereby minimizing the brittleness tendency of the gel in the dried state. Hence, we believe that the hierarchical assembly of our hydrogel owing to its functional activity, host toxicity, and stability could possibly be used as an antimicrobial ointment for bacterial infection control.

Ag2O Nanoparticles as a Candidate for Antimicrobial Compounds of the New Generation

“…Ag 2 O NPs not only effectively inhibited bacterial growth, but also killed them. Therefore, Ag 2 O NPs are a perfect candidate for the role of a therapeutic agent against nosocomial bacterial infections [37]. The antimicrobial effect against Gram-positive bacteria is more pronounced than against Gram-negative ones.…”

A Novel Biodegradable Composite Polymer Material Based on PLGA and Silver Oxide Nanoparticles with Unique Physicochemical Properties and Biocompatibility with Mammalian Cells

“…In our study, we proposed that 0.001% of silver oxide nanoparticles is similar to minimum inhibitory concentration (MIC) 10 µg/mL. MIC, in case of silver oxide nanoparticles coated other by polyethersulfone, cellulose, and hydrogel, is above 2-8000 µg/mL (Table 1) [17][18][19]95,96]. Moreover, the nanocomposite is suitable for anchoring and spreading mammalian cells (Figure 11).…”

“…[15][16][17][18]. In addition, polymer films supplemented by metal oxide NPs and the surfaces of such films acquire antibacterial properties [19][20][21][22][23]. At present, such nanocomposites are already used to create cover, textile, and even building materials with antibacterial properties [23,24].…”

Cytotoxic, Antidiabetic, and Antioxidant Study of Biogenically Improvised Elsholtzia blanda and Chitosan-Assisted Zinc Oxide Nanoparticles

“…Engineered metal oxide NPs such as copper oxides, 18 manganese oxides, 19 titanium oxides, 20 aluminium oxides, 21 iron oxides, 22 cerium oxides, 23 and silver oxides 24 are among the most common NPs having unique properties and applicability in diverse fields. Behaving as a good n-type semiconductor, ZnO NPs are gaining significant interest among researchers.…”

“…16 Faisal et al synthesized zinc oxide NPs using the aqueous fruit extract of Myristica fragrans which had good antibacterial, antidiabetic, antioxidant, antiparasitic, and larvicidal properties. 17 Engineered metal oxide NPs such as copper oxides, 18 manganese oxides, 19 titanium oxides, 20 aluminium oxides, 21 iron oxides, 22 cerium oxides, 23 and silver oxides 24 are among the most common NPs having unique properties and applicability in diverse fields. Behaving as a good n-type semiconductor, ZnO NPs are gaining significant interest among researchers.…”