Hibernoma

Chatterton, Barry E.; Mensforth, Dominic; Coventry, Brendon J.; Cohen, Penelope

doi:10.1097/00003072-200205000-00016

Cited by 27 publications

(9 citation statements)

References 6 publications

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“…These findings include hypointensity to fatty tissue on T2-weighted images and hyperintense signal intensity on TIRM images. Large intratumoural blood vessels, heterogeneous contrast enhancement and strong FDG uptake are further imaging signs [ 2 , 3 , 10 , 15 , 16 ].…”

Section: Discussionmentioning

confidence: 99%

“…In 18 F-fluorodeoxyglucose (FDG) positron emission tomography-computed tomography (PET/CT) high uptake is measured in hibernomas due to the metabolic activity of brown fat. Therefore, differentiation from malignant tumours is difficult [ 3 , 10 , 15 , 16 ]. Compared to liposarcomas, hibernomas often show higher standardized uptake values (SUVs) and change of FDG avidity in follow-up.…”

Section: Introductionmentioning

confidence: 99%

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Hibernoma – two patients with a rare lipoid soft-tissue tumour

et al. 2015

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BackgroundHibernomas are rare benign soft-tissue tumours arising from brown fat tissue. Although imaging characteristics are not specific certain imaging features, common locations and patient demographics may suggest hibernoma as a differential diagnosis.Case presentationWe report on two 48-year-old male patients with hibernoma. The tumour presented with local swelling of the inguinal region in the first patient and was an incidental imaging finding in the second patient. Imaging included magnetic resonance imaging in both patients and computed tomography as well as 18 F-fluorodeoxyglucose positron emission tomography-computed tomography in the second patient. In both cases histological diagnosis was initially based on excisional and needle core biopsy, respectively. Complete surgical resection confirmed the diagnosis of hibernoma thereafter.ConclusionIn soft tissue tumours with fatty components hibernoma may be included into the differential diagnosis. Because of the risk of sampling errors in hibernoma-like tissue components of myxoid and well-differentiated liposarcoma, complete resection is mandatory. This article also reviews the current imaging literature of hibernomas.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Hibernoma – two patients with a rare lipoid soft-tissue tumour

et al. 2015

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“…Due to the lack of specific symptoms, it is not rare to detect the lesion as an incidental finding [1-3]. Imaging features of MRI are not characteristic with predominantly hypointense or isointense signal in the fatty tissue on T2-weighted images [3]. On CT scan hibernoma can appear as a low-attenuation mass with diffuse enhancement [2].…”

Section: Discussionmentioning

confidence: 99%

“…Typically the tumor occurs in people aged between 30 and 50 years [2]. In the evaluation of this type of lesion, the traditional diagnostic techniques (including computed tomography (CT) and magnetic resonance imaging (MRI) are not able to distinguish with certainty between benign tumor, such as hibernoma or lipoma, and malignant tumor, such as liposarcoma [3]. Therefore after the identification of a potential neoplasia with fat tissue characteristics, further diagnostic investigations are necessary [4-7].…”

Section: Introductionmentioning

confidence: 99%

A Rare Case of Hibernoma Occasionally Identified by 18F-fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in a Patient with Lung Cancer

Penna¹,

Quartuccio

Testa³

et al. 2017

Cureus

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Hibernoma is a benign tumor arising from brown fat tissue. Conventional imaging techniques are not able to differentiate it from other benign lesions or malignant fatty tumors. We report the case of a 73-year-old patient who underwent a thorax computed tomography (CT) and was then referred to our department for metabolic assessment of a solitary lung nodule. An F18-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG-PET/CT) scan was performed and demonstrated, in addition, a highly metabolic fat-containing lesion mimicking a malignant fatty tumor in the left great pectoralis muscle. The lesion was excised and resulted to be a hibernoma. This case shows that hibernoma can appear as a malignant-like lesion on 18F-FDG-PET/CT scan as per other imaging techniques, and the grade of FDG uptake does not accurately reflect malignancy in this fat-containing tumor. However, 18F-FDG-PET/CT with its whole-body scanning capability may represent a useful imaging tool in identifying, in the course of an imaging study for oncological evaluation, additional incidental findings such as benign fat-containing lesions that may require a surgical approach.

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“…[12131415] This feature is not typically seen with either a lipoma or a well-differentiated liposarcoma; as this is due to the increased vascularity and increased cellular activity with increased glucose turn over as seen in hibernomas. [115] These typically do not undergo malignant transformation and complete surgical resection is the treatment. [1] These imaging features help us to narrow the differential diagnosis and adequately plan the treatment.…”

Section: Discussionmentioning

confidence: 99%