Hexosomes formed from glycerate surfactants—Formulation as a colloidal carrier for irinotecan

Boyd, Ben J.; Whittaker, Darryl V.; Khoo, Shui‐Mei; Davey, Greg

doi:10.1016/j.ijpharm.2006.03.010

Cited by 133 publications

(86 citation statements)

References 24 publications

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“…The feasibility of cubosomes as carriers for parenteral, topical, and buccal delivery of drugs has been reported in the literature (14)(15)(16)(17)(18)(19). Formulations based on this technology have been reported to have improved tolerance and drug bioavailability (20).…”

Section: Introductionmentioning

confidence: 99%

Nanostructured Cubosomes in a Thermoresponsive Depot System: An Alternative Approach for the Controlled Delivery of Docetaxel

et al. 2015

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Abstract. The aim of the present study was to develop and evaluate a thermoresponsive depot system comprising of docetaxel-loaded cubosomes. The cubosomes were dispersed within a thermoreversible gelling system for controlled drug delivery. The cubosome dispersion was prepared by dilution method, followed by homogenization using glyceryl monooleate, ethanol and Pluronic ® F127 in distilled water. The cubosome dispersion was then incorporated into a gelling system prepared with Pluronic ® F127 and Pluronic ® F68 in various ratios to formulate a thermoresponsive depot system. The thermoresponsive depot formulations undergo a thermoreversible gelation process i.e., they exists as free flowing liquids at room temperature, and transforms into gels at higher temperatures e.g., body temperature, to form a stable depot in aqueous environment. The mean particle size of the cubosomes in the dispersion prepared with Pluronic ® F127, with and without the drug was found to be 170 and 280 nm, respectively. The prepared thermoresponsive depot system was evaluated by assessing various parameters like time for gelation, injectability, gel erosion, and in-vitro drug release. The drug-release studies of the cubosome dispersion before incorporation into the gelling system revealed that a majority (∼97%) of the drug was released within 12 h. This formulation also showed a short lag time (∼3 min). However, when incorporated into a thermoresponsive depot system, the formulation exhibited an initial burst release of ∼21%, and released only ∼39% drug over a period of 12 h, thus indicating its potential as a controlled drug delivery system.

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Section: Introductionmentioning

confidence: 99%

Nanostructured Cubosomes in a Thermoresponsive Depot System: An Alternative Approach for the Controlled Delivery of Docetaxel

et al. 2015

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“…5) would not be expected if drug was rapidly released from the particles. The high surface area and short diffusional distance for release from cubosomes and hexosomes means that burst release is expected in the presence of a sink condition [13,49]. Gastric emptying of the formulation into the intestine would be required to facilitate release and absorption.…”

Section: Discussionmentioning

confidence: 99%

“…The use of V 2 and H 2 phases as drug delivery carriers for various routes of administration in the form of bulk systems and as cubosomes or hexosomes has been proposed [11][12][13][14][15][16][17][18]. Several studies have examined the use of liquid-crystalline carriers as oral delivery systems in vitro using glyceryl monooleate (GMO) systems [19][20][21]; however, there are few examples in the literature where in vivo sustained release performance has been reported.…”

Section: Introductionmentioning

confidence: 99%

Nanostructured reverse hexagonal liquid crystals sustain plasma concentrations for a poorly water-soluble drug after oral administration

Nguyen

Hanley

Porter

et al. 2011

Drug Deliv. and Transl. Res.

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Reverse hexagonal (H2) liquid crystals formed from selachyl alcohol were demonstrated to sustain the absorption of the poorly water-soluble drug cinnarizine (CZ) after oral administration to rats. When CZ was administered as a bolus lipid solution in selachyl alcohol, the T max was observed to be 23.5 ± 5.9 h, significantly longer than the control suspension (1 h). Administration of selachyl alcohol as dispersed nanoparticles (hexosomes) also resulted in a sustained plasma profile, with drug concentrations maintained from 20 to 40 ng/mL over the first 24 h after administration. Sustained absorption of CZ from the selachyl alcohol hexosomes led to a significant enhancement (p < 0.05) in oral bioavailability (F% = 17%) compared to the control CZ suspension (9%). Analysis of selachyl alcohol hexosomes using small-angle x-ray scattering indicated that neither the presence of CZ (7 mg/g) nor simulated intestinal fluid altered the H2 nanostructure. Selachyl alcohol is not susceptible to digestion. Prolonged absorption from the selachyl alcohol-based H2 systems was attributed to the non-digestible nature of the lipid, similar to non-digestible phytantriol cubic (V2) systems previously reported. Furthermore, the likely presence of non-sink conditions in the gastric compartment provides a drug reservoir requiring gastric emptying to stimulate drug release from the formulation. This study highlights the potential use of non-digestible liquid crystalline systems generally and nanostructured liquid crystalline particles in particular as novel sustained oral drug delivery systems.

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“…These particles are internally self-assembled, hence they are also called "isasomes" ("somes" here refers to particles) [69]. More specifically, the particles with the cubic self-assembly are called "cubosomes" [66], while "hexosomes" are the particles having an interior of the hexagonal type [70]. It is possible to modulate the internal self-assembly into other nanostructures including lamellar phase, sponge phase, micellar cubic phase and inverse micelles [15].…”

Section: Lipid Nanostructured Emulsions: Next Level Of Structural Hiementioning

confidence: 99%

Lipid Self-Assemblies and Nanostructured Emulsions for Cosmetic Formulations

Kulkarni

2016

Cosmetics

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A majority of cosmetic products that we encounter on daily basis contain lipid constituents in solubilized or insolubilized forms. Due to their amphiphilic nature, the lipid molecules spontaneously self-assemble into a remarkable range of nanostructures when mixed with water. This review illustrates the formation and finely tunable properties of self-assembled lipid nanostructures and their hierarchically organized derivatives, as well as their relevance to the development of cosmetic formulations. These lipid systems can be modulated into various physical forms suitable for topical administration including fluids, gels, creams, pastes and dehydrated films. Moreover, they are capable of encapsulating hydrophilic, hydrophobic as well as amphiphilic active ingredients owing to their special morphological characters. Nano-hybrid materials with more elegant properties can be designed by combining nanostructured lipid systems with other nanomaterials including a hydrogelator, silica nanoparticles, clays and carbon nanomaterials. The smart materials reviewed here may well be the future of innovative cosmetic applications.

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Hexosomes formed from glycerate surfactants—Formulation as a colloidal carrier for irinotecan

Cited by 133 publications

References 24 publications

Nanostructured Cubosomes in a Thermoresponsive Depot System: An Alternative Approach for the Controlled Delivery of Docetaxel

Nanostructured Cubosomes in a Thermoresponsive Depot System: An Alternative Approach for the Controlled Delivery of Docetaxel

Nanostructured reverse hexagonal liquid crystals sustain plasma concentrations for a poorly water-soluble drug after oral administration

Lipid Self-Assemblies and Nanostructured Emulsions for Cosmetic Formulations

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