Hexamoll DINCH plasticised PVC containers for the storage of platelets

Nair, C Sundaresan; Vidya, R.; Ashalatha, P M

doi:10.4103/0973-6247.75972

Cited by 11 publications

(9 citation statements)

References 15 publications

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“…Studies that evaluated canine PC in 100% plasma observed a significant reduction of platelet count, it was associated with platelet activation and formation of microaggregates, fragmentation or loss of platelet integrity, and these may be the reasons of reduction of platelet count during the storage period [ 20 , 21 ]. Our results are in agreement with previous studies evaluating human PC in SSP+ and Composol, where no variation in platelet count was observed [ 3 , 15 , 19 ]. Van der Meer (2012) stated difference in this parameter, the authors suggest that the low viscosity of the PAS, makes it necessary to adapt and standardize the centrifugation protocols [ 24 , 25 ].…”

Section: Discussionsupporting

confidence: 93%

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In vitro properties of concentrated canine platelets stored in two additive solutions: a comparative study

Hlavac

Lasta²,

Dalmolin³

et al. 2017

BMC Vet Res

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BackgroundPlatelet transfusion therapy poses many challenges in veterinary clinical practice. Lack of readily available blood donors, short shelf-life, and inability to administer a sufficient number of platelets to meet a dog’s transfusion need are the major difficulties encountered. Platelet additive solutions are already in use at American and European human blood banks, showing to be a realistic alternative. This study compares the in vitro platelet function in plasma, Composol, or SSP+ during storage for 13 days. Platelet rich plasma-platelet concentrate with 35% plasma and 65% platelet additive solutions (Composol or SSP+) and a control group (100% plasma) were prepared. Swirling, platelet count, blood gases, metabolic variables, platelet activation markers, and apoptosis markers were analyzed on days 1, 5, 9 and 13.ResultsSwirling was well preserved and pH was acceptable (> 6.2) during storage for all platelet additive solutions units until day 9. SSP + units showed more stable pH and metabolic variables until day 13. Platelets in plasma showed higher glucose consumption than in Composol or in SSP+. The platelet additive solutions units showed better platelet metabolism maintenance, reduced glucose consumption and lactate production. The apoptotic markers were still low for 9 days in platelet concentrates with platelet additive solutions, suggesting the possibility to extend the shelf life with the use of SSP+ or Composol.ConclusionsOur findings suggest that the uses of Composol and SSP+ in canine platelet concentrates are potential alternatives in veterinary blood banks.Electronic supplementary materialThe online version of this article (10.1186/s12917-017-1236-8) contains supplementary material, which is available to authorized users.

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Section: Discussionsupporting

confidence: 93%

“…Swirling is a non-invasive method for assessing platelet viability; it is caused by light diffraction due to the alignment of normal discoid shaped platelets. In this evaluation zero indicates no swirling and 3 indicates great swirling [ 15 ]. Residual leukocyte count was performed using the Nageotte chamber.…”

Section: Methodsmentioning

confidence: 99%

In vitro properties of concentrated canine platelets stored in two additive solutions: a comparative study

Hlavac

Lasta²,

Dalmolin³

et al. 2017

BMC Vet Res

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“…Despite what has been reported in the literature for decades, bags containing plasticizers known to disrupt AAG-drug binding continue to be widely used for blood collection with the intended use in both research and in the clinical setting. DEHP is essential in maintaining the shelf life of blood products up to 42 days as it protects the membrane of the red blood cell (133). Transfusion recipients routinely receive blood that has been collected and stored in these bags.…”

Section: Effect Of Plasticizers On Drug-protein Bindingmentioning

confidence: 99%

Pharmacokinetic and Pharmacodynamic Considerations for Drugs Binding to Alpha-1-Acid Glycoprotein

Smith¹,

Waters

2018

Pharm Res

106

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According to the free drug hypothesis only the unbound drug is available to act at physiological sites of action, and as such the importance of plasma protein binding primarily resides in its impact on pharmacokinetics and pharmacodynamics. Of the major plasma proteins, alpha-1-acid glycoprotein (AAG) represents an intriguing one primarily due to the high affinity, low capacity properties of this protein.In addition, there are marked species and age differences in protein expression, homology and drug binding affinity. As such, a thorough understanding of drug binding to AAG can help aid and improve the translation of pharmacokinetic/pharmacodynamic (PK/PD) relationships from preclinical species to human as well as adults to neonates. This review provides a comprehensive overview of our current understanding of the biochemistry of AAG; endogenous function, impact of disease, utility as a biomarker, and impact on PK/PD. Experimental considerations are discussed as well as recommendations for understanding the potential impact of AAG on PK through drug discovery and early development.

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“…PLT storage containers with polyolefin are also FDA approved and in use, which do not contain phthalates 46 . Also in development is a nonphthalate plastic container, 1,2‐cyclohexane‐dicarboxylic acid, di‐isononylester for PLT storage 47 …”

Section: Alternativesmentioning

confidence: 99%