Hexagonal cobalt oxide nanosheet-based enzymeless electrochemical uric acid sensor with improved sensitivity

Nagal, Vandana; Khan, Marya; Masrat, Sakeena; Alam, Shamshad; Ahmad, Akil; Alshammari, Mohammed B.; Bhat, Kiesar Sideeq; Ahmad, Rafiq

doi:10.1039/d2nj06331j

Cited by 14 publications

(7 citation statements)

References 39 publications

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“…The electrochemical analysis was performed using EIS, CV, and DPV measurements. We utilized the previously optimized cobalt oxide amount and pH to get the optimum sensing response of the fabricated sensor [ 36 , 37 , 38 ]. The CV was performed in a 5 mM probe solution of potassium hexacyanoferrate (purity ≥ 9 9%, K 3 [Fe(CN) 6 ]) in 0.1 M KCl under varying scan rates from 10 mVs −1 to 200 mVs −1 .…”

Section: Methodsmentioning

confidence: 99%

“…Nanostructures of cobalt oxide are being used to construct non-enzymatic electrochemical sensors due to simple and low-cost synthesis processes, chemical stability, and fast charge transfer property [ 29 , 30 , 35 ]. Recently, nano-berry, porous, and hexagonal nanosheet-like nanostructures of cobalt oxides were utilized to fabricate non-enzymatic UA sensors [ 36 , 37 , 38 ]. Kogularasu et al synthesized polyhedron-shaped Co 3 O 4 nanostructures to construct a high-sensitivity hydrogen peroxide sensor [ 39 ].…”

Section: Introductionmentioning

confidence: 99%

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Highly Sensitive Electrochemical Non-Enzymatic Uric Acid Sensor Based on Cobalt Oxide Puffy Balls-like Nanostructure

et al. 2023

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Early-stage uric acid (UA) abnormality detection is crucial for a healthy human. With the evolution of nanoscience, metal oxide nanostructure-based sensors have become a potential candidate for health monitoring due to their low-cost, easy-to-handle, and portability. Herein, we demonstrate the synthesis of puffy balls-like cobalt oxide nanostructure using a hydrothermal method and utilize them to modify the working electrode for non-enzymatic electrochemical sensor fabrication. The non-enzymatic electrochemical sensor was utilized for UA determination using cyclic voltammetry (CV) and differential pulse voltammetry (DPV). The puffy balls-shaped cobalt oxide nanostructure-modified glassy carbon (GC) electrode exhibited excellent electro-catalytic activity during UA detection. Interestingly, when we compared the sensitivity of non-enzymatic electrochemical UA sensors, the DPV technique resulted in high sensitivity (2158 µA/mM.cm2) compared to the CV technique (sensitivity = 307 µA/mM.cm2). The developed non-enzymatic electrochemical UA sensor showed good selectivity, stability, reproducibility, and applicability in the human serum. Moreover, this study indicates that the puffy balls-shaped cobalt oxide nanostructure can be utilized as electrode material for designing (bio)sensors to detect a specific analyte.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Highly Sensitive Electrochemical Non-Enzymatic Uric Acid Sensor Based on Cobalt Oxide Puffy Balls-like Nanostructure

et al. 2023

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“…Initially, CV and EIS response were measured in a 5 mM potassium hexacyanoferrate (ΙΙΙ) probe solution having KCl (0.1 M). All the UA sensing analysis was performed in PBS solution at room temperature (25 °C) and at an optimized pH (i.e., 7.4). ,, …”

Section: Experimental Sectionmentioning

confidence: 99%

“…All the UA sensing analysis was performed in PBS solution at room temperature (25 °C) and at an optimized pH (i.e., 7.4). 14,50,51 Nanomaterial Characterizations. The crystal phase and crystallinity of the ZnO and ZnO NR-CuO NS hybrid nanostructures were characterized using XRD in the range of 25−75°with a screening speed of 5°/minute.…”

Section: ■ Experimental Sectionmentioning

confidence: 99%

Electrochemical Sensing of Uric Acid with Zinc Oxide Nanorods Decorated with Copper Oxide Nanoseeds

Masrat,

Nagal,

Khan

et al. 2023

ACS Appl. Nano Mater.

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The use of hybrid nanostructured nanomaterials in sensor development has the potential to overcome the sensitivity issue due to the combination of different nanoscale features of the desired nanomaterials that are accumulated together and offer entirely different characteristics. The sensitive quantification of biomolecules is required for early disease diagnosis. Herein, a hybrid (zinc oxide nanorods modified with copper oxide nanoseeds (ZnO NRs-CuO NSs)) nanostructured nanomaterial-integrated sensor that detects uric acid (UA) is reported. A low-temperature solution-based method was described for ZnO NR and ZnO NR-CuO NS hybrid nanomaterial syntheses. The use of the ZnO NR-CuO NS hybrid nanomaterial resulted in ultra-high sensitivity (1477.88 μA/mM cm 2 ) toward UA detection using the differential pulse voltammetry (DPV) technique. DPV resulted in ∼7.7 times better sensitivity compared to cyclic voltammetry (CV)-measured sensitivity (187.32 μA/mM cm 2 ). The surface modification of ZnO NRs with CuO NS "hybrid nanostructures" showed a significant impact and synergistic effect that enhanced the sensing performance. Furthermore, selectivity, stability, fabrication reproducibility, and applicability in the real sample are other crucial factors of this ZnO NR-CuO NS hybrid nanomaterial-based UA sensor.

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“…The different nanostructured forms of cobalt oxide are used for sensing various analytes. [10][11][12][13] Researchers have adopted different methods for the recovery of valuable metals from spent batteries. The recycling of lithium and cobalt metals is done by various techniques including electrodialysis coupled with chelation, 14 leaching with inorganic acids [15][16][17][18][19][20][21] and hydrometallurgical methods involving natural organic acids.…”

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confidence: 99%

Development of Pd@MWCNT-Co₃O₄ Electrode Sensors Using Cobalt Recovered from Spent Lithium Ion Batteries

Reshma,

Manu

2023

J. Electrochem. Soc.

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The rampant use of various types of energy storage devices for different applications poses a great threat to the environment as most of the materials are not recycled properly after their usage. Battery materials that are exposed to the environment without proper recycling or recovery protocol are of more concern. In the present work, the chemical components recovered from spent lithium batteries were processed through suitable methods and utilized for the fabrication of electrode materials for sensor application. The present work demonstrates a highly sensitive and cost-effective method for fabricating disposable non-enzymatic glucose sensors based on Pd functionalized multiwall carbon nanotube (MWCNT)-Co3O4 electrode using cobalt recovered from a spent Li-ion battery. The incorporation of palladium onto the MWCNT and further deposition of this composite onto the Co3O4 substrate greatly enhanced the glucose sensing characteristics. The sensing behavior of the Co3O4 electrode and Pd@MWCNT-Co3O4 electrode towards glucose electro-oxidation were compared using cyclic voltammetry and chronoamperometric techniques. A very low detection limit of 0.6µM was obtained by the Pd@MWCNT-Co3O4 electrode towards glucose sensing. The sensor fabrication process was economical and possessed excellent stability, selectivity and good reproducibility.

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Hexagonal cobalt oxide nanosheet-based enzymeless electrochemical uric acid sensor with improved sensitivity

Abstract: Enzymeless sensors have been known as highly stable, fast, and reliable devices for several biomolecule detection and early disease diagnosis. Hence, it is crucial to fabricate enzymeless sensors with high...

Cited by 14 publications

References 39 publications

Highly Sensitive Electrochemical Non-Enzymatic Uric Acid Sensor Based on Cobalt Oxide Puffy Balls-like Nanostructure

Highly Sensitive Electrochemical Non-Enzymatic Uric Acid Sensor Based on Cobalt Oxide Puffy Balls-like Nanostructure

Electrochemical Sensing of Uric Acid with Zinc Oxide Nanorods Decorated with Copper Oxide Nanoseeds

Development of Pd@MWCNT-Co₃O₄ Electrode Sensors Using Cobalt Recovered from Spent Lithium Ion Batteries

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Hexagonal cobalt oxide nanosheet-based enzymeless electrochemical uric acid sensor with improved sensitivity

Abstract: Enzymeless sensors have been known as highly stable, fast, and reliable devices for several biomolecule detection and early disease diagnosis. Hence, it is crucial to fabricate enzymeless sensors with high...

Cited by 14 publications

References 39 publications

Highly Sensitive Electrochemical Non-Enzymatic Uric Acid Sensor Based on Cobalt Oxide Puffy Balls-like Nanostructure

Highly Sensitive Electrochemical Non-Enzymatic Uric Acid Sensor Based on Cobalt Oxide Puffy Balls-like Nanostructure

Electrochemical Sensing of Uric Acid with Zinc Oxide Nanorods Decorated with Copper Oxide Nanoseeds

Development of Pd@MWCNT-Co3O4 Electrode Sensors Using Cobalt Recovered from Spent Lithium Ion Batteries

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Development of Pd@MWCNT-Co₃O₄ Electrode Sensors Using Cobalt Recovered from Spent Lithium Ion Batteries