Heterylferrocenes. Synthesis and use

Organometallic Tetrazole Derivatives: Preparation and Application to Organic Synthesis

“…These reagents alkylate the 5-R-tetrazoles or the corresponding salts in neutral or acid media to afford isomeric N-(α-ferrocenylalkyl)-5-R-tetrazoles. By this procedure tetrazoles 73 and 74 were obtained [82][83][84][85]. oxychloride environment.…”

Synthesis of 4-(1-adamantyl)-3-polyfluoromethyl-1H-pyrazoles

“…The chemistry of hetaryl-substituted adamantanes was reviewed in [3,4]. Some adamantyl-substituted pyrazoles were synthesized from adamantyl-containing 1,3-diketones [4][5][6][7]. However, there are no published data on fluorinated adamantyl-containing pyrazoles and methods for their preparation.…”

“…Introduction of an adamantane fragment into organic molecules changes their properties and often enhances or modifies their biological activity [2]. The chemistry of hetaryl-substituted adamantanes was reviewed in [3,4]. Some adamantyl-substituted pyrazoles were synthesized from adamantyl-containing 1,3-diketones [4][5][6][7].…”

Adamantylation of azoles by 1,3-dehydroadamantane: I. N-adamantylation of imidazoles by 1,3-dehydroadamantane

“…The main procedure for preparation of certain adamantyl-containing azoles, in particular, imidazoles, is the acid-catalyzed adamantylation of the corresponding azoles with various functional derivatives of adamantane [1][2][3][4][5][6]. However this method provides relatively low yields of the target products (45-75%), and strong acids are used.…”

“…The chemistry of adamantyl-containing heterocyclic compounds was recently under vigorous development [1,2]. This is due to the possibility of their application as biologically active compounds.…”