Heteroxanthin, diatoxanthin and diadinoxanthin from tribonema aequale

Strain, Harold H.; Benton, F. L.; Grandolfo, M.; Aitzetmüller, K.; Svec, Walter A.; Katz, Joseph

doi:10.1016/s0031-9422(00)85778-7

Cited by 29 publications

(18 citation statements)

References 5 publications

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“…Heteroxanthin was also found in Euglena gracilis (274,275), and Xanthophyceae species (276). The principal crystallizable xanthophylls of Tribonema aequala were diatoxanthin, heteroxanthin, and diadinoxanthin (277).…”

Section: Metabolites Of Macro-and Microalgal Speciesmentioning

confidence: 90%

Anticancer activity of natural and synthetic acetylenic lipids

Dembitsky¹

2006

Lipids

128

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This review is a comprehensive survey of acetylenic lipids and their derivatives, obtained from living organisms, that have anticancer activity. Acetylenic metabolites belong to a class of molecules containing triple bond(s). They are found in plants, fungi, microorganisms, and marine invertebrates. Although acetylenes are common as components of terrestrial plants, fungi, and bacteria, it is only within the last 30 years that biologically active polyacetylenes having unusual structural features have been reported from plants, cyanobacteria, algae, invertebrates, and other sources. Naturally occurring aquatic acetylenes are of particular interest since many of them display important biological activities and possess antitumor, antibacterial, antimicrobial, antifouling, antifungal, pesticidal, phototoxic, HIV-inhibitory, and immunosuppressive properties. There is no doubt that they are of great interest, especially for the medicinal and/or pharmaceutical industries. This review presents structures and describes cytotoxic and anticancer activities only for more than 300 acetylenic lipids and their derivatives isolated from living organisms.

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Section: Metabolites Of Macro-and Microalgal Speciesmentioning

confidence: 90%

Anticancer activity of natural and synthetic acetylenic lipids

Dembitsky¹

2006

Lipids

128

View full text Add to dashboard Cite

show abstract

“…Heteroxanthin was also found in Euglena gracilis [66], and Xanthophyceae species [67]. The principal crystallizable xanthophylls of Tribonema aequale were diatoxanthin, heteroxanthin, and diadinoxanthin [68].…”

Section: Extracts Ofmentioning

confidence: 99%

Acetylenic Aquatic Anticancer Agents and Related Compounds

Dembitsky

Levitsky

Gloriozova

et al. 2006

Natural Product Communications

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Although acetylenes are common as components of terrestrial plants, it is only within the last 30 years that biologically active polyacetylenes having unusual structural features have been reported from aquatic organisms: cyanobacteria, algae, fungi, invertebrates, and other sources. Naturally occurring aquatic acetylenes are of particular interest since many of them display important biological activities and possess antitumor, antibacterial, antimicrobial, antifouling, antifungal, pesticidal, phototoxic, HIV inhibitory, and immuno-suppressive properties. There is no doubt that they are of great interest, especially for the medicinal and/or pharmaceutical industries. This review presents structures and describes cytotoxic and anticancer activities of more than 230 acetylenic metabolites isolated from aquatic organisms. With the computer program PASS some additional biological activities are also predicted, which point toward possible new applications of these compounds. This review emphasizes the role of aquatic acetylenic compounds as an important source of leads for drug discovery.

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“…Several attempts had been made to identi~ the chloroplast pigments of the Xanthophyceae (Kuhn & Brockman, 1932;~arter, Heilbron & Lythgoe, 1939;Seybold, Egle & Hiilsbruch, 1941 ;Heilbron, 1942;Strain, Manning & Hardin, 1944;Jamikorn, 1954;Strain, 1958;gestfik, 1963;Allen et al, 1964;Thomas & Goodwin, 1965;Chapman & Haxo, 1966) before Kleinig & Egger (1967) reported that Vaucheria and Botrydium contained p-carotene, chlorophyll a, antheraxanthin, three tri-esters of the previously undescribed xanthophyll vaucheriaxanthin, an unknown pigment which was subsequently identified by Falk & Kleinig (1968) as trollixanthin, and traces of cryptoxanthin epoxide and zeaxanthin, the latter pigment being produced by a light-induced conversion of antheraxanthin (Kleinig, 1967). Subsequent studies largely fall into two groups, those primarily dealing with the correct identification of the pigments (Falk & Kleinig, 1968;Egger, Nitsche & Kleinig, 1969;Strain et al, 1968Strain et al, , 1970Stransky & Hager, 1970a) and those primarily concerned with recognition of the fact that some of the unicellular forms belong to a separate taxonomic group (Whittle & Casselton, 1969, 1975Guillard & Lorenzen, 1972) corresponding to the Eustigmatophyceae of Hibberd & Leedale (1970, 1971b, 1972. Falk & Kleinig (1968) claimed that Tribonema had the same pigments as Vaucheria and Botrydium, except that the minor xanthophyll cryptoxanthin was missing.…”

Section: T H E C H L O R O P L a S T P I G M E N T S Of T H E A L G Amentioning

confidence: 99%

“…Whittle & Casselton (1969) agreed with them and also suggested that the pigments of Mischococcus sphaerocephalus resembled those of Tribonema. It now appears that the pigment which was isolated by both Kleinig & Egger (1967) and Whittle & Casselton (1969) and identified as antheraxanthin is, in fact, the closely related xanthophyll diadinoxanthin (Strain et al, 1968(Strain et al, , 1970Egger et al, 1969;Stransky & Hager, 1970a). Stransky & Hager (1970a) used a very sensitive system of thin-layer chromatography (TLC) in conjunction with infrared spectroscopy and microchemical tests for identifying functional groups to study the carotenoids of eight members of the Xanthophyceae sensu stricto.…”

Section: T H E C H L O R O P L a S T P I G M E N T S Of T H E A L G Amentioning

confidence: 99%