Heterotrimeric G proteins control stem cell proliferation through <scp>CLAVATA</scp> signaling in <i>Arabidopsis</i>

Ishida, Takashi; Tabata, Ryo; Yamada, Masakazu; Aida, Mitsuhiro; Mitsumasu, Kanako; Yamaguchi, Katsushi; Shigenobu, Shuji; Higuchi, Makie; Tsuji, Hiroyuki; Shimamoto, Ko; Hasebe, Mitsuyasu; Fukuda, Hiroo; Sawa, Shinichiro

doi:10.15252/embr.201678010

Cited by 39 publications

(64 citation statements)

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“…These are present in ciliates as well as in unikonts up to mammals (Plattner & Verkhratsky, , ). There are examples of the presence of some signalling pathways in animals and plants, but with fragmentary evidence for ciliates. There are only suggestions for the occurrence of trimeric G‐proteins in ciliates, although they are well documented for unikonts, from Dictyostelium discoideum (Manahan et al, ) to man, and for ‘higher’ bikonts, such as plants (Ishida et al, ). One may expect their identification also in ciliates.…”

Section: Discussionmentioning

confidence: 99%

Signalling in ciliates: long- and short-range signals and molecular determinants for cellular dynamics

Plattner

2015

Biol Rev

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In ciliates, unicellular representatives of the bikont branch of evolution, inter- and intracellular signalling pathways have been analysed mainly in Paramecium tetraurelia, Paramecium multimicronucleatum and Tetrahymena thermophila and in part also in Euplotes raikovi. Electrophysiology of ciliary activity in Paramecium spp. is a most successful example. Established signalling mechanisms include plasmalemmal ion channels, recently established intracellular Ca -release channels, as well as signalling by cyclic nucleotides and Ca . Ca -binding proteins (calmodulin, centrin) and Ca -activated enzymes (kinases, phosphatases) are involved. Many organelles are endowed with specific molecules cooperating in signalling for intracellular transport and targeted delivery. Among them are recently specified soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs), monomeric GTPases, H -ATPase/pump, actin, etc. Little specification is available for some key signal transducers including mechanosensitive Ca -channels, exocyst complexes and Ca -sensor proteins for vesicle-vesicle/membrane interactions. The existence of heterotrimeric G-proteins and of G-protein-coupled receptors is still under considerable debate. Serine/threonine kinases dominate by far over tyrosine kinases (some predicted by phosphoproteomic analyses). Besides short-range signalling, long-range signalling also exists, e.g. as firmly installed microtubular transport rails within epigenetically determined patterns, thus facilitating targeted vesicle delivery. By envisaging widely different phenomena of signalling and subcellular dynamics, it will be shown (i) that important pathways of signalling and cellular dynamics are established already in ciliates, (ii) that some mechanisms diverge from higher eukaryotes and (iii) that considerable uncertainties still exist about some essential aspects of signalling.

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Section: Discussionmentioning

confidence: 99%

Signalling in ciliates: long- and short-range signals and molecular determinants for cellular dynamics

Plattner

2015

Biol Rev

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“…Unlike animals, plant genomes encode few GPCRs, and plant Gα could be self‐activated (Johnston et al ; Urano et al ; Bradford et al ; Pandey and Vijayakumar ), suggesting that plant G proteins sense signals in different ways from those of animals. Several studies implied that receptor‐like kinases (RLKs) are potential factors that percept and transduce signals to G proteins (Lease et al ; Llorente et al ; Bommert et al ; Liu et al ; Ishida et al ; Aranda‐Sicilia et al ; Choudhury and Pandey ; Liang et al ; Yu et al ; Peng et al ). Plant genomes encode hundreds of RLKs, which are single‐transmembrane proteins (De Smet et al ).…”

Section: The Potential Mechanisms Of G Proteins In Sensing Upstream Smentioning

confidence: 99%

Control of grain size by G protein signaling in rice

2019

JIPB

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Heterotrimeric G proteins are involved in multiple cellular processes in eukaryotes by sensing and transducing various signals. G protein signaling in plants is quite different from that in animals, and the mechanisms of plant G protein signaling are still largely unknown. Several recent studies have provided new insights into the mechanisms of G protein signaling in rice grain size and yield control. In this review, we summarize recent advances on the function of G proteins in rice grain size control and discuss the potential genetic and molecular mechanisms of plant G protein signaling.

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“…Moreover, we found that AGB1 and FER act additively or synergistically in salt response, suggesting that the AGB1 and FER pathways overlap but are not in a linear relationship. A synergistic relationship has also been observed for AGB1 and the RLK RPK2 in SAM maintenance (Ishida et al, ). These results suggest that RLK signalling has both G protein‐dependent and AGB1‐independent aspects, and that epistatic relationships between AGB1 and FER differ across different phenotypes.…”

Section: Discussionmentioning

confidence: 81%

“…In recent years, RLKs have been implicated as functioning together with G proteins in plant development and defence responses and may serve as plant G protein‐coupled receptor (GPCRs) distinct from the classical 7TM‐domain GPCRs of animals. For example, in Arabidopsis, AGB1 physically interacts with RECEPTOR‐LIKE PROTEIN KINASE 2 (RPK2) but not CLAVATA 1 (CLV1) or CLV2, and acts synergistically with RPK2 in shoot apical meristem (SAM) maintenance (Ishida et al, ). In maize, the Gα subunit COMPACT PLANTS2 (CT2) and a CLAVATA RLK FASCIATED EAR2 (FEA2) appeared in an immunoprecipitate with CT2 and showed epistasis in the control of SAM diameter (Bommert, Nagasawa, & Jackson, ; Je et al, ).…”

Section: Discussionmentioning

confidence: 99%

Inter‐relationships between the heterotrimeric Gβ subunit AGB1, the receptor‐like kinase FERONIA, and RALF1 in salinity response

Assmann

2018

Plant Cell & Environment

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Plant heterotrimeric G proteins modulate numerous developmental stress responses. Recently, receptor-like kinases (RLKs) have been implicated as functioning with G proteins and may serve as plant G-protein-coupled-receptors. The RLK FERONIA (FER), in the Catharantus roseus RLK1-like subfamily, is activated by a family of polypeptides called rapid alkalinization factors (RALFs). We previously showed that the Arabidopsis G protein β subunit, AGB1, physically interacts with FER, and that RALF1 regulation of stomatal movement through FER requires AGB1. Here, we investigated genetic interactions of AGB1 and FER in plant salinity response by comparing salt responses in the single and double mutants of agb1 and fer. We show that AGB1 and FER act additively or synergistically depending on the conditions of the NaCl treatments. We further show that the synergism likely occurs through salt-induced ROS production. In addition, we show that RALF1 enhances salt toxicity through increasing Na accumulation and decreasing K accumulation rather than by inducing ROS production, and that the RALF1 effect on salt response occurs in an AGB1-independent manner. Our results indicate that RLK epistatic relationships are not fixed, as AGB1 and FER display different genetic relationships to RALF1 in stomatal versus salinity responses.

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Heterotrimeric G proteins control stem cell proliferation through CLAVATA signaling in Arabidopsis

Cited by 39 publications

References 0 publications

Signalling in ciliates: long- and short-range signals and molecular determinants for cellular dynamics

Signalling in ciliates: long- and short-range signals and molecular determinants for cellular dynamics

Control of grain size by G protein signaling in rice

Inter‐relationships between the heterotrimeric Gβ subunit AGB1, the receptor‐like kinase FERONIA, and RALF1 in salinity response

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