Heterotheca inuloides: Anti-inflammatory and analgesic effect

Gene, R. M.; Segura, Laura; Adzet, T.; Marín, Eva; Iglesias, José

doi:10.1016/s0378-8741(97)00155-4

Cited by 133 publications

(100 citation statements)

References 12 publications

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“…Acetic acid-induced abdominal constriction test is used for the evaluation of peripheral analgesic activity (Gene et al, 1998;Faruk et al 2015). The test material demonstrated significant analgesic activity in acetic acid-induced writhing test in mice.…”

Section: Discussionmentioning

confidence: 99%

In vitro Membrane Stabilizing and In vivo Analgesic Activities of Boehmeria glomerulifera Miq. in Swiss-Albino Mice Model

et al. 2016

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Boehmeria glomerulifera Miq. is an indigenous plant of Bangladesh. Traditional healers use this plant to treat various diseases. The crude methanol extract of whole plant of B. glomerulifera and its Kupchan fractions were screened for in vitro membrane stabilizing and only the crude extract at doses of 200-and 400-mg/kg body weight were screened for analgesic activity in mice model in order to establish the medicinal values of this plant. The membrane stabilizing activity of the extractives was evaluated by the ability of test materials to inhibit hypotonic solution-and heat-induced haemolysis of human erythrocytes. Moreover, the analgesic activity of methanol extract was evaluated by acetic acid induced writhing method and tail immersion method in mice. In hypotonic solution-and heat-induced conditions, the crude methanol extract showed inhibition of haemolysis by 64.80±0.34% and 21.63±0.76%, respectively as compared to 77.74±0.67% and 40.41±0.69% demonstrated by the standard, acetyl salicylic acid. On the other hand, the analgesic activity was determined for its peripheral and central pharmacological responses using acetic acid-induced writhing test and tail immersion method at doses of 200-and 400-mg/kg body weight. The extract reduced the acetic acid-induced writhings significantly (p < 0.05) in a dose dependent manner with the highest activity observed at 400 mg/kg (46.0%) body weight when compared to that of Diclofenac sodium (64.0%), as the standard drug. A significant increase (p < 0.01) of latency period was also found in tail immersion method. Therefore, the present study established that the methanol extract of B. glomerulifera possesses moderate membrane stabilizing and significant analgesic activities.

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Section: Discussionmentioning

confidence: 99%

In vitro Membrane Stabilizing and In vivo Analgesic Activities of Boehmeria glomerulifera Miq. in Swiss-Albino Mice Model

et al. 2016

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“…21 The method has been associated with prostanoids in general, e.g. increased levels of prostaglandins E2 (PGE2) and PGF2α in peritoneal fl uids, 22,23 as well as lipoxygenase products. 24,25 The abdominal contraction is related to the sensitization of nociceptive receptors to PG.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the Antinociceptive potential of Ethanolic extract of leaves of Bryophyllum pinnatum in Experimental animals.

Handique

Dutta

Lahkar

2015

Int J Basic Clin Pharmacol

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“…To ascertain analgesic activity, we performed both acetic acid-induced writhing and formalininduced pain tests. The first method is extensively used for the assessment of peripheral antinociceptive activity [26]. It is very sensitive and able to detect anti-nociceptive effect of compounds at dose levels that may appear inactive in other methods such as the tailflick test [27].…”

Section: Discussionmentioning

confidence: 99%

Central Nervous System Depressant, Analgesic and Antidiarrheal Effects of the Seed Extracts of <i>Dimocarpus longan</i> Lour in Rats

Ripa¹,

Morshed²,

Sharmin³

et al. 2014

Trop. J. Pharm Res

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Heterotheca inuloides: Anti-inflammatory and analgesic effect

Cited by 133 publications

References 12 publications

In vitro Membrane Stabilizing and In vivo Analgesic Activities of Boehmeria glomerulifera Miq. in Swiss-Albino Mice Model

In vitro Membrane Stabilizing and In vivo Analgesic Activities of Boehmeria glomerulifera Miq. in Swiss-Albino Mice Model

Evaluation of the Antinociceptive potential of Ethanolic extract of leaves of Bryophyllum pinnatum in Experimental animals.

Central Nervous System Depressant, Analgesic and Antidiarrheal Effects of the Seed Extracts of <i>Dimocarpus longan</i> Lour in Rats

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