Heteropterys tomentosa (A. Juss.) infusion counteracts Cyclosporin a side effects on the ventral prostate

Freitas, Karine Moura de; Monteiro, Juliana Castro; Gomes, Marcos de Lucca Moreira; Taboga, Sebastião Roberto; Dolder, Heidi

doi:10.1186/1472-6882-13-30

Cited by 5 publications

(10 citation statements)

References 37 publications

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“…The treatment protocol was similar to that previously employed (Monteiro et al 2008, Freitas et al 2013.…”

Section: Experimental Animals and Protocolmentioning

confidence: 99%

“…The methodology used for infusion preparation was the same as that used by previous authors (Monteiro et al 2008, Freitas et al 2012b, 2013. In brief, Heteropterys tomentosa A. Juss.…”

Section: Preparation Of the Treatment Solutionsmentioning

confidence: 99%

“…Cyclosporin A (Sandimmun Neoral ® , Novartis Pharma AG, Switzerland) was administered in a therapeutic dose (15mg/kg body weight) as in previous studies (Chung et al 2005, Kotolová et al 2006, Monteiro et al 2008, Bohmer et al 2011, Freitas et al 2012a, 2013.…”

Section: Preparation Of the Treatment Solutionsmentioning

confidence: 99%

“…The administrations of CsA for 21 (Buffoli et al 2005, Rezzani et al 2005a, b, Türk et al 2007 or 56 days (Monteiro et al 2008, Freitas et al 2012a, 2013 were chosen based on previous experiments reported in literature.…”

Section: Experimental Animals and Protocolmentioning

confidence: 99%

“…The antioxidant properties of H. tomentosa root extract (BST0298) were demonstrated by Mattei et al (2001), and this same extract was also efficient in the recovery of learning and memory of aged rats (Galvão et al 2002). H. tomentosa root infusion has been successfully used to reduce CsA-related effects on testicular tissue (Monteiro et al 2008), ventral prostate and biochemical parameters related to hepatotoxicityplasma levels of glutamic oxaloacetic transaminase, total and indirect bilirubin and cholesterol (Freitas et al 2013).…”

Section: Introductionmentioning

confidence: 99%

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The effects of Cyclosporin A and Heteropterys tomentosaon the rat liver

Freitas

Almeida

Monteiro

et al. 2015

An. Acad. Bras. Ciênc.

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Cyclosporin A (CsA) is a widely employed immunosuppressive drug that is associated with several side effects, among then hepatotoxicity. Heteropterys tomentosa is a Brazilian plant efficient in reducing damage caused by CsA on the rat testis and prostate. The aim of this study was to evaluate the effect of CsA and H. tomentosa (administered isolated or simultaneously) on the liver of Wistar rats. The animals were treated daily with water (control), CsA (15mg/kg/day), H. tomentosa infusion or CsA+H. tomentosa, for 21 or 56 days. The treatments did not alter liver morphology or cause fibrosis. H. tomentosa administered for 21 days increased the number of hepatocyte nuclei and Kupffer cell volumetric proportion. After 56 days of treatment, H. tomentosa administration did not alter the parameters analyzed. Biochemical plasma dosages and liver stereology showed impairment caused by CsA-treatment after 21 days; these results were not observed after 56 days of treatment. The simultaneous treatment with CsA and H. tomentosa for 21 or 56 days did not alleviate nor accentuate CsA hepatic effects. The present study showed that the 21 days treatment with CsA caused more alteration to the liver than the 56 days treatment; this could be related to hepatic recovery after the long term treatment.

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“…The treatment protocol was similar to that previously employed (Monteiro et al 2008, Freitas et al 2013.…”

Section: Experimental Animals and Protocolmentioning

confidence: 99%

“…The methodology used for infusion preparation was the same as that used by previous authors (Monteiro et al 2008, Freitas et al 2012b, 2013. In brief, Heteropterys tomentosa A. Juss.…”

Section: Preparation Of the Treatment Solutionsmentioning

confidence: 99%

Section: Preparation Of the Treatment Solutionsmentioning

confidence: 99%

Section: Experimental Animals and Protocolmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The effects of Cyclosporin A and Heteropterys tomentosaon the rat liver

Freitas

Almeida

Monteiro

et al. 2015

An. Acad. Bras. Ciênc.

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Immunosuppressants and Male Reproduction

Drobnis

Nangia

2017

Advances in Experimental Medicine and Biology

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Prolonged use of immunosuppressant medications is occasionally seen in infertile men with chronic inflammatory conditions; autoimmune disorders; or an organ or hematopoietic stem cell transplant. Chronic inflammation impacts negatively on male reproductive endpoints, so immunosuppressant therapy can produce improvements. Corticosteroids have been used to treat antisperm antibodies and even as an empirical treatment for male infertility in general. Trials of these methods have provided mixed results on semen quality and fertility, with improvement, no change and negative effects reported by different investigators. In a substantial number of observational studies, patients on long-term therapy with prednisone for chronic inflammatory disease, testosterone levels were lower compared to untreated controls, though randomized controlled trials have not been conducted. Similarly decreases in testosterone have been reported in men receiving corticosteroids to minimize transplant rejection; however, most were treated with multiple immunosuppressive medications that may have contributed to this effect. A large number of trials of healthy men treated with corticosteroids have shown some disruption in reproductive hormone levels, but other studies reported no effect. Studies in monkeys, rats (at human equivalent dose), cattle, sheep, and horses have shown endocrine disruption, including low testosterone with dexamethasone treatment. Of the cytostatic immunosuppressives, which have high potential for cellular damage, cyclophosphamide has received the most attention, sometimes lowering sperm counts significantly. Methotrexate may decrease sperm numbers in humans and has significant negative impacts in rodents. Other chemotherapeutic drugs used as immunosuppressants are likely to impact negatively on male fertility endpoints, but few data have been collected. The TNF-α Inhibitors have also received little experimental attention. There is some evidence that the immunophilin modulators: cyclosporine, sirolimus, and everolimus cause endocrine disruption and semen quality impairment. As we review in this chapter, results in experimental species are concerning, and well-designed studies are lacking for the effects of these medications on reproductive endpoints in men.

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