The effects of Cyclosporin A and Heteropterys tomentosaon the rat liver

Abstract

Cyclosporin A (CsA) is a widely employed immunosuppressive drug that is associated with several side effects, among then hepatotoxicity. Heteropterys tomentosa is a Brazilian plant efficient in reducing damage caused by CsA on the rat testis and prostate. The aim of this study was to evaluate the effect of CsA and H. tomentosa (administered isolated or simultaneously) on the liver of Wistar rats. The animals were treated daily with water (control), CsA (15mg/kg/day), H. tomentosa infusion or CsA+H. tomentosa, for 21 or 56 days. The treatments did not alter liver morphology or cause fibrosis. H. tomentosa administered for 21 days increased the number of hepatocyte nuclei and Kupffer cell volumetric proportion. After 56 days of treatment, H. tomentosa administration did not alter the parameters analyzed. Biochemical plasma dosages and liver stereology showed impairment caused by CsA-treatment after 21 days; these results were not observed after 56 days of treatment. The simultaneous treatment with CsA and H. tomentosa for 21 or 56 days did not alleviate nor accentuate CsA hepatic effects. The present study showed that the 21 days treatment with CsA caused more alteration to the liver than the 56 days treatment; this could be related to hepatic recovery after the long term treatment.

Costus afer leaf extract protects against testicle damage caused by cyclosporine A in adult male Wistar rats through an antioxidant mechanism

“…Furthermore, previous studies reported that the utilisation of cyclosporine A harmed testicular function, causing sperm counts, sperm motility and fertility to decline (Gawish et al, 2016; Monteiro, Predes, Matta, & Dolder, 2008; Srinivas et al, 1998). The main mechanism that underlies most of the cyclosporine‐induced toxicities is reported to be the generation of oxygen free radicals (De Freitas et al, 2015). Cyclosporine A induced structural and functional toxicity in the testicular tissue via oxidative stress mechanisms (Türk et al, 2007).…”

Heteropterys tomentosaA. Juss: Toxicological and adaptogenic effects in experimental models

“…Results opposite to those of Galvão et al (2011) on the learning and memory of rats were reported by Paula-Freire et al (2013) during an 80-day treatment with the hydroethanolic extract of the H. tomentosa roots, as well as no evidence of an adaptogenic effect. De Freitas (2015) also reported hepatotoxicity on oral administration (75.76 mg/kg) of the aqueous infusion of H. tomentosa in rats treated for 21 days.…”

Immunosuppressive treatment affects morphology and apoptotic intensity of the liver in pregnant Wistar rats

“…These medicines are used in combined therapy, usually as a complex of three different drugs, following kidney transplantation. C by binding cyclophilin inhibits calcineurin and therefore leads to decreased interleukin-2 transcription and thus deactivates T cells [7]. It can be replaced by Tc, which acts differently in an initial pathway, as Tc binds to FK506.…”

“…E exhibits antineoplastic and antiproliferative properties such as inhibiting fibroblast proliferation and fibrosis, but it also inhibits replication of the hepatitis C virus (HCV) [5]. Mycophenolate mofetil is an immunosuppressive drug acting by inhibition of inosine monophosphate dehydrogenase and thus selectively inhibits lymphocyte proliferation [7]. From above-mentioned drugs E and MMF are contraindicated during pregnancy [5].…”