Abstract:p-Tolyl 2-thienyl ketone (I) condensed with dimethyl succinate in the presence of potassium t-butoxide to give the trans (SC,H,/CO,Me) half-ester (IIIa) whose configuration was deduced by cyclization to the corresponding benzo[b]thiophene derivatives. Carbamates, esters, cyclic hydrazides and substituted phenolic and acetic acids useful as antibacterial and antiinflamatory agents were obtained. T h e reaction of ketone I with malononitrile to give ylidenemalononitrile I1 was also considered.
Aus dem Thienyl‐keton (I) erhält man mit Bernsteinsäureester (II) das Kondensat (IIIa), das zu (IIIb) verseift und mit Hydrazin zu (IVa) kondensiert wird ; Methylisocyanat ergibt das Addukt (IVb).
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