Heterologous Biosynthesis of Health-Promoting Baicalein in Lycopersicon esculentum

Liao, Jingjing; Xie, Lei; Liu, Tingyao; Mo, Changming; Cui, Shengrong; Jia, Xunli; Huang, Xueliang; Luo, Zuliang; Ma, Xiaojun

doi:10.3390/molecules27103086

Cited by 5 publications

(1 citation statement)

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“…Combined with phylogenetic analysis, four SbUGAT genes were screened out to be able to use UDP-glucuronic acid as a sugar donor to catalyze the conversion of baicalein to baicalin. On the basis of the illumination of the biosynthesis pathway, heterologous production of baicalin has been successfully realized in both E. coli [ 209 ] and model plant Lycopersicon esculentum [ 210 ].…”

Section: Flavonoidsmentioning

confidence: 99%

Biosynthesis Investigations of Terpenoid, Alkaloid, and Flavonoid Antimicrobial Agents Derived from Medicinal Plants

et al. 2022

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The overuse of antibiotics in the past decades has led to the emergence of a large number of drug-resistant microorganisms. In recent years, the infection rate caused by multidrug-resistant microorganisms has been increasing, which has become one of the most challenging problems in modern medicine. Plant-derived secondary metabolites and their derivatives have been identified to display significant antimicrobial abilities with good tolerance and less adverse side effects, potentially having different action mechanisms with antibiotics of microbial origin. Thus, these phyto-antimicrobials have a good prospect in the treatment of multidrug-resistant microorganisms. Terpenoids, alkaloids, and flavonoids made up the predominant part of the currently reported phytochemicals with antimicrobial activities. Synthetic biology research around these compounds is one of the hotspot fields in recent years, which not only has illuminated the biosynthesis pathways of these phyto-antimicrobials but has also offered new methods for their production. In this review, we discuss the biosynthesis investigations of terpenoid, alkaloid, and flavonoid antimicrobial agents—using artemisinin and oleanolic acid (terpenoids), berberine and colchicine (alkaloids), and baicalin (flavonoids) as examples—around their antimicrobial action mechanisms, biosynthesis pathway elucidation, key enzyme identification, and heterologous production, in order to provide useful hints for plant-derived antimicrobial agent discovery and development.

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Section: Flavonoidsmentioning

confidence: 99%