The role of redox active copper(II) on antioxidant properties of the flavonoid baicalein: DNA protection under Cu(II)-Fenton reaction and Cu(II)-ascorbate system conditions

Jomová, Klaudia; Cvik, Marcel; Lauro, Peter; Valko, Marián; Čižmár, E.; Alomar, Suliman Yousef; Alwasel, Saleh; Olekšák, Patrik; Chrienová, Žofia; Nepovimová, Eugenie; Kuča, Kamil; Rhodes, Christopher J.

doi:10.1016/j.jinorgbio.2023.112244

Cited by 9 publications

(4 citation statements)

References 53 publications

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“…Most importantly, the outcomes are strongly supported by the experimental data. 58 Antioxidative Activity Type III. Aside from the presented behaviors, antioxidants may also interfere with biological targets and repair them following hydrogen atom or electron transfer reactions.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

Unveiling the Antioxidative Potential of Galangin: Complete and Detailed Mechanistic Insights through Density Functional Theory Studies

Spiegel

2024

J. Org. Chem.

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Section: ■ Results and Discussionmentioning

confidence: 99%

Unveiling the Antioxidative Potential of Galangin: Complete and Detailed Mechanistic Insights through Density Functional Theory Studies

Spiegel

2024

J. Org. Chem.

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“…Presumably, the inhibitory effect of polyphenols on the oxidative burst of neutrophils is brought about through various mechanisms [102,105]. As was mentioned above, they can scavenge ROS and bind transition metal ions, which, under certain conditions, leads to the inhibition of the Fenton reaction [106][107][108][109][110] and protection of cells against the damage mediated by metal ions [110][111][112].…”

Section: Discussionmentioning

confidence: 99%

A Comparative Study of the Inhibitory Effect of Some Flavonoids and a Conjugate of Taxifolin with Glyoxylic Acid on the Oxidative Burst of Neutrophils

Shubina,

Kozina,

Shatalin

2023

IJMS

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During the storage, processing, and digestion of flavonoid-rich foods and beverages, a condensation of flavonoids with toxic carbonyl compounds occurs. The effect of the resulting products on cells remains largely unknown. The aim of the present study was to evaluate the effects of quercetin, taxifolin, catechin, eriodictyol, hesperetin, naringenin, and a condensation product of taxifolin with glyoxylic acid on the oxidative burst of neutrophils. It was found that the flavonoids and the condensation product inhibited the total production of ROS. Flavonoids decreased both the intra and extracellular ROS production. The condensation product had no effect on intracellular ROS production but effectively inhibited the extracellular production of ROS. Thus, the condensation of flavonoids with toxic carbonyl compounds may lead to the formation of compounds exhibiting potent inhibitory effects on the oxidative burst of neutrophils. The data also suggest that, during these reactions, the influence of a fraction of flavonoids and their polyphenolic derivatives on cellular functions may change. On the whole, the results of the study provide a better understanding of the effects of polyphenols on human health. In addition, these results reveal the structure–activity relationship of these polyphenols and may be useful in a search for new therapeutic agents against diseases associated with oxidative stress.

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“…98,99 Due to the unique phenolic OH groups of FPPs, they can chelate highly redox-active metal ions to form stable complexes, thus enhancing their protective effect against oxidative damage. 100 This complex formation reduces the involvement of free metal ions in the Fenton reaction 101 and other processes that generate free radicals, thus reducing the extent of oxidative stress 102 and allowing the in vitro assessment of antioxidant activity. Kim et al found that Sargassum horneri ethanol (SHE) (0 to 500 μg/mL) extract containing polyphenols chelated with transition metals (such as Si, Mg, Al, Ti, and Fe) on the surface of MLE-12 cells.…”

Section: Fpps Classification and Antioxidant Propertiesmentioning

confidence: 99%

Recent Advances in the Inhibition of Membrane Lipid Peroxidation by Food-Borne Plant Polyphenols via the Nrf2/GPx4 Pathway

Zhang,

Liu,

et al. 2024

J. Agric. Food Chem.

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Lipid peroxidation (LP) leads to changes in the fluidity and permeability of cell membranes, affecting normal cellular function and potentially triggering apoptosis or necrosis. This process is closely correlated with the onset of many diseases. Evidence suggests that the phenolic hydroxyl groups in food-borne plant polyphenols (FPPs) make them effective antioxidants capable of preventing diseases triggered by cell membrane LP. Proper dietary intake of FPPs can attenuate cellular oxidative stress, especially damage to cell membrane phospholipids, by activating the Nrf2/GPx4 pathway. Nuclear factor E2-related factor 2 (Nrf2) is an oxidative stress antagonist. The signaling pathway regulated by Nrf2 is a defense transduction pathway of the organism against external stimuli such as reactive oxygen species and exogenous chemicals. Glutathione peroxidase 4 (GPx4), under the regulation of Nrf2, is the only enzyme that reduces cell membrane lipid peroxides with specificity, thus playing a pivotal role in regulating cellular ferroptosis and counteracting oxidative stress. This study explored the Nrf2/GPx4 pathway mechanism, antioxidant activity of FPPs, and mechanism of LP. It also highlighted the bioprotective properties of FPPs against LP and its associated mechanisms, including (i) activation of the Nrf2/GPx4 pathway, with GPx4 potentially serving as a central target protein, (ii) regulation of antioxidant enzyme activities, leading to a reduction in the production of ROS and other peroxides, and (iii) antioxidant effects on LP and downstream phospholipid structure. In conclusion, FPPs play a crucial role as natural antioxidants in preventing LP. However, further in-depth analysis of FPPs coregulation of multiple signaling pathways is required, and the combined effects of these mechanisms need further evaluation in experimental models. Human trials could provide valuable insights into new directions for research and application.

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The role of redox active copper(II) on antioxidant properties of the flavonoid baicalein: DNA protection under Cu(II)-Fenton reaction and Cu(II)-ascorbate system conditions

Cited by 9 publications

References 53 publications

Unveiling the Antioxidative Potential of Galangin: Complete and Detailed Mechanistic Insights through Density Functional Theory Studies

Unveiling the Antioxidative Potential of Galangin: Complete and Detailed Mechanistic Insights through Density Functional Theory Studies

A Comparative Study of the Inhibitory Effect of Some Flavonoids and a Conjugate of Taxifolin with Glyoxylic Acid on the Oxidative Burst of Neutrophils

Recent Advances in the Inhibition of Membrane Lipid Peroxidation by Food-Borne Plant Polyphenols via the Nrf2/GPx4 Pathway

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