Heteroleptic oxidovanadium(IV)-malate complex improves glucose uptake in HepG2 and enhances insulin action in streptozotocin-induced diabetic rats

Nigro, Thanise Pitelli de; Manica, Graciele Cristiane More; Souza, Susan Webber de; Jesus, Carlos Henrique Alves; Bottini, Rúbia Camila Ronqui; Missina, Juliana Morais; Valdameri, Gláucio; Nunes, Giovana G.; Cunha, Joice Maria da; Picheth, Geraldo; Rego, Fabiane Gomes de Moraes

doi:10.1007/s10534-022-00413-5

Cited by 2 publications

(6 citation statements)

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“…In contrast, it has been demonstrated that vanadyl compounds [ 59 ] and oxidovanadium(IV)-malate complex [ 60 ] can enhance the effectiveness of administered insulin in animal models. Similarly, vanadyl sulfate improves hepatic and muscle insulin sensitivity in patients with type 2 diabetes [ 61 ].…”

Section: Discussionmentioning

confidence: 99%

“…We have previously evaluated the [VO(bpy)(mal)]·H 2 O insulin-like properties. Similarly, this compound was found to improve glycemia only in association with insulin; however, 30 mg/kg (0.0469 mmol/kg) of [VO(bpy)(mal)]·H 2 O, the maximum dose tested, associated with insulin decreased blood glucose concentrations by 30% compared to that in the insulin treatment [ 60 ]. Comparatively, Vox2 was more efficient, promoting and associated with insulin and a return to glycemia, similar to the control group at concentrations of 30 and 100 mg/kg.…”

Section: Discussionmentioning

confidence: 99%

“…Selection of Vox2 dose: The Vox2 compound was initially analyzed using a neurobehavioral test to determine the doses to be used in the prolonged stage of this study. The doses of 30 and 100 mg/kg were chosen based on range extracted from the literature [ 14 , 60 , 62 ] available and on solubilization in distilled water. The oral doses tested did not affect animals neurobehavior.…”

Section: Methodsmentioning

confidence: 99%

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A Non-Toxic Binuclear Vanadium(IV) Complex as Insulin Adjuvant Improves the Glycemic Control in Streptozotocin-Induced Diabetic Rats

Lopes,

Baptistella,

Nunes

et al. 2024

Pharmaceuticals

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Diabetes mellitus (DM) complications are a burden to health care systems due to the associated consequences of poor glycemic control and the side effects of insulin therapy. Recently. adjuvant therapies, such as vanadium compounds, have gained attention due to their potential to improve glucose homeostasis in patients with diabetes. In order to determine the anti-diabetic and antioxidant effects of the oxidovanadium(IV) complex (Et3NH)2[{VO(OH}2)(ox)2(µ–ox)] or Vox2), rats with streptozotocin (STZ)-induced diabetes were treated with 30 and 100 mg/kg of Vox2, orally administered for 12 days. Vox2 at 100 mg/kg in association with insulin caused a 3.4 times decrease in blood glucose in STZ rats (424 mg/dL), reaching concentrations similar to those in the normoglycemic animals (126 mg/dL). Compared to insulin alone, the association with Vox2 caused an additional decrease in blood glucose of 39% and 65% at 30 and 100 mg/kg, respectively, and an increased pancreatic GSH levels 2.5 times. Vox2 alone did not cause gastrointestinal discomfort, diarrhea, and hepatic or renal toxicity and was not associated with changes in blood glucose level, lipid profile, or kidney or liver function. Our results highlight the potential of Vox2 in association with insulin in treating diabetes.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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A Non-Toxic Binuclear Vanadium(IV) Complex as Insulin Adjuvant Improves the Glycemic Control in Streptozotocin-Induced Diabetic Rats

Lopes,

Baptistella,

Nunes

et al. 2024

Pharmaceuticals

Self Cite

View full text Add to dashboard Cite

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“…Vanadium-based compounds are known to exert insulin-enhancing activity and have demonstrated their antidiabetic activity in vitro and in vivo [ 1 , 2 , 3 , 4 ]. Vanadium complexes demonstrate superior biological effects in contrast to salts.…”

Section: Introductionmentioning

confidence: 99%

“…Despite this, new alternatives for glycemic control in these patients have been studied using an insulin-resistant diabetic animal model induced via dexamethasone [ 26 ]. In this context, oxidovanadium complexes have emerged as an efficient therapeutic proposal capable of controlling metabolic disorders associated with DM [ 1 , 2 , 3 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

Dexamethasone-Induced Insulin Resistance Attenuation by Oral Sulfur–Oxidovanadium(IV) Complex Treatment in Mice

Batista,

Lima,

Gomes

et al. 2024

Pharmaceuticals

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Vanadium compounds are known to exert insulin-enhancing activity, normalize elevated blood glucose levels in diabetic subjects, and show significant activity in models of insulin resistance (IR). Faced with insulin resistance, the present work investigates the antidiabetic performance of a known oxidovanadium(IV)-based coordination compound—[VIVO(octd)]—and effects associated with glucocorticoid-induced insulin resistance in mice. The effects of [VIVO(octd)] were evaluated in a female Swiss mice model of insulin resistance induced by seven days of dexamethasone treatment in comparison with groups receiving metformin treatment. Biological assays such as hematological, TyG index, hepatic lipids, glycogen, oxidative stress in the liver, and oral glucose tolerance tests were evaluated. [VIVO(octd)] was characterized with 51V NMR, infrared spectroscopy (FTIR), electron paramagnetic resonance (EPR), electronic absorption spectroscopy, and mass spectrometry (ESI–FT–MS). The [VIVO(octd)] oral treatment (50 mg/kg) had an antioxidant effect, reducing 50% of fast blood glucose (p < 0.05) and 25% of the TyG index, which is used to estimate insulin resistance (p < 0.05), compared with the non-treated group. The oxidovanadium–sulfur compound is a promising antihyperglycemic therapeutic, including in cases aggravated by insulin resistance induced by glucocorticoid treatment.

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Heteroleptic oxidovanadium(IV)-malate complex improves glucose uptake in HepG2 and enhances insulin action in streptozotocin-induced diabetic rats

Cited by 2 publications

References 64 publications

A Non-Toxic Binuclear Vanadium(IV) Complex as Insulin Adjuvant Improves the Glycemic Control in Streptozotocin-Induced Diabetic Rats

A Non-Toxic Binuclear Vanadium(IV) Complex as Insulin Adjuvant Improves the Glycemic Control in Streptozotocin-Induced Diabetic Rats

Dexamethasone-Induced Insulin Resistance Attenuation by Oral Sulfur–Oxidovanadium(IV) Complex Treatment in Mice

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