Heterogeneous Chitosan@copper Catalyzed Selective C(sp3)–H Sulfonylation of Ketone Hydrazones with Sodium Sulfinates: Direct Access to β-Ketosulfones

Abstract

The exploration of inexpensive and stable heterogeneous catalysts for C–S coupling reactions remains a challenging issue. Herein, we successfully prepared a new biomass-derived copper catalyst and applied it to the selective C(sp3)–H-directed sulfonylation of ketone hydrazones with commercial sodium sulfinates. The catalyst was characterized using different spectroscopic and microscopic techniques. Importantly, the prepared biomass-supported Cu catalyst catalyzed the C–S coupling reaction with considerably high activity. A variety of aryl and alkyl sulfinates were converted to the corresponding sulfones with good yields. In particular, the heterogeneous catalyst could be recovered easily after the synthesis and consecutively used at least five times with no appreciable decrease in the catalytic activity. Lastly, the copper catalyst is expected to have further applications in organic reactions catalyzed by Cu/CuO2.

The role of oil solutions of thiosulfonates in the modulation of antioxidant parameters in rat kidneys

“…In thiosulfonate studies, investigating the antioxidant system of the kidneys and spleen allows for an assessment of whether these compounds can induce oxidative stress and cellular damage in these organs. Research may involve measuring the levels of antioxidants such as glutathione, superoxide dismutase (SOD), catalase, and other antioxidant enzymes, as well as evaluating the levels of oxidative markers such as malondialdehyde (MDA) [17] or reactive oxygen species (ROS). In our study, we investigated the radical scavenging and antiradical activities of S-ethyl-4-aminobenzenethiosulfonate (ETS), S-allyl-4aminobenzenethiosulfonate (ATS), and S-allyl-4-acetylaminobenzenethiosulfonate (AATS) in vivo to establish the relationship between their structure and activity.…”