Abstract:1 The aim of this study was to identify the a,-adrenoceptor subtypes present on the circular and longitudinal myometrial layers of the dioestrous guinea-pig uterus.2 Homogenate binding studies using [3H]WB-4 10 1 identified one saturable binding site in preparations of circular myometrium. Pre-incubation of homogenates with chloroethylclonidine (50 ,UM) reduced binding by N 82%. Noradrenaline competed for two [3H]WB-4 10 1 binding sites except after chloroethylclonidine pre-incubation, when it competed for one… Show more
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