Heterogeneity of symptom pattern, psychosocial factors, and pathophysiological mechanisms in severe functional dyspepsia

Fischler, Benjamin; Tack, Jan; Gucht, Véronique De; Shkedy, Ziv; Persoons, Philippe; Broekaert, Dorine; Molenberghs, Geert; Janssens, Jozef

doi:10.1053/gast.2003.50155

Cited by 129 publications

(127 citation statements)

References 32 publications

(32 reference statements)

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“…In this study, early satiety symptom was associated with delayed gastric emptying and days of sickness leave. By contrast, epigastric pain and epigastric burning symptoms were correlated with gastric hypersensitivity and psychopathology or somatization (Fischler et al, 2003). Some gut hormones are known to be the cause of delayed gastric emptying e.g.…”

Section: Discussionmentioning

confidence: 93%

Helicobacter pylori Infection Impacts on Functional Dyspepsia in Thailand

Piriyapong

Tangaroonsanti²,

Mahachai³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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Section: Discussionmentioning

confidence: 93%

Helicobacter pylori Infection Impacts on Functional Dyspepsia in Thailand

Piriyapong

Tangaroonsanti²,

Mahachai³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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“…The FD symptom subtypes were developed as a result of factor analysis studies, [29][30][31] as well as reports that up to 80% of patients reported symptom aggravation after ingestion of a meal, 32 and the observation that response to therapy differed by symptom subgroup in clinical trials of proton pump inhibitors in FD. 33 Novel therapies for dyspepsia continue to be developed and tested based on these subtypes.…”

Section: Prevalence Of Erosive Esophagitis According To Fd Definitionmentioning

confidence: 99%

The Rome III Criteria for the Diagnosis of Functional Dyspepsia in Secondary Care Are Not Superior to Previous Definitions

et al. 2014

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“…The pathophysiology of FD is poorly understood. Recent studies showed that FD is a heterogeneous disorder wherein different pathophysiologic disturbances underlie different symptoms (11). Delayed gastric emptying and abnormalities of gastrointestinal motility have been observed in a considerable proportion of patients with FD (5).…”

Section: Discussionmentioning

confidence: 99%

Association between polymorphism of dopamine D2 receptor genes and therapeutic effect of domperidone in functional dyspepsia

Xiang

Ma²,

Mou³

et al. 2015

Turk J Gastroenterol

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Background/Aims: Functional dyspepsia (FD) is a common gastrointestinal disease, for which domperidone is one of the most commonly used drugs. This study aimed to investigate the potential causes of the varying therapeutic effects of domperidone among FD patients. Materials and Methods: The effects of domperidone therapy in patients with FD were evaluated using a clinical symptom score combined with real-time ultrasonography examination of antral motor index. Single nucleotide polymorphism (SNP) of the dopamine D 2 receptor genes 141C Ins/Del, A-241G, and TaqI, were analyzed by ligase detection reaction. Results: The results of real-time ultrasonography correlated with clinical symptom scores. Single nucleotide polymorphism analysis of dopamine D 2 receptor TaqI gene showed that the genotype frequencies of "C/C", "C/T", and "T/T" in the effective group were 51.35%, 31.08%, and 17.57%, respectively; the allele frequencies were 66.89% and 33.11%. In the ineffective group, the genotype frequencies of "C/C", "C/T", and "T/T" were 17.81%, 52.05%, and 30.14%, respectively; and the allele frequencies were 43.84% and 56.16%. The difference was statistically different between the two groups (p<0.01). Conclusion: Clinical symptom scores combined with real-time ultrasonography is effective in evaluating the therapeutic effect of domperidone in patients with functional dyspepsia. The therapeutic effect of domperidone in these patients was associated with polymorphism of dopamine D 2 receptor TaqI gene.

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Heterogeneity of symptom pattern, psychosocial factors, and pathophysiological mechanisms in severe functional dyspepsia

Abstract: In a tertiary care population, functional dyspepsia is a heterogeneous condition characterized by 4 major dimensions differentially associated with psychopathological and physiopathological mechanisms.

Cited by 129 publications

References 32 publications

Helicobacter pylori Infection Impacts on Functional Dyspepsia in Thailand

Helicobacter pylori Infection Impacts on Functional Dyspepsia in Thailand

The Rome III Criteria for the Diagnosis of Functional Dyspepsia in Secondary Care Are Not Superior to Previous Definitions

Association between polymorphism of dopamine D2 receptor genes and therapeutic effect of domperidone in functional dyspepsia

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