Heterogeneity of human Platelets

Karpatkin, Simon; Charmatz, Arthur

doi:10.1172/jci106063

Cited by 348 publications

(38 citation statements)

References 24 publications

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“…Another alternate approach may be to rely on mean platelet volume (MPV) as a surrogate for platelet function instead of measuring directly platelet aggregability [20–22]. Higher MPV indicates larger platelets on average which may be more reactive, and which can be measured more routinely in labs as part of complete blood cell counts.…”

Section: Discussionmentioning

confidence: 99%

Platelet function as a risk factor for venous thromboembolism in the Framingham Heart Study

Puurunen

Hwang

O’Donnell

et al. 2017

Thrombosis Research

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Introduction The relationship of venous thromboembolism (VTE) with platelet reactivity is unclear. Platelet function plays a key role in arterial thrombosis. Evidence suggests antiplatelet agents also effects in reducing VTE. Our aim is to describe the role of baseline platelet function in development of VTE in the community-based Framingham Heart Study (FHS) cohort. Materials and Methods Participants in the Framingham Offspring cohort fifth examination and Omni cohort first examination were eligible. We used light transmission aggregometry to measure platelet aggregation in response to collagen and a range of ADP and epinephrine doses. The study population consisted of 2831 participants [average age 54.3 y; 57% female]. Results and Conclusions During a median follow-up of 20.4 years, we observed 138 incident VTE events. In age-, sex- and cohort-adjusted analysis an increase in collagen lag time was associated with increased risk for incident VTE (HR 1.01 [1.00–1.02]; p=0.049). Increased maximal aggregation to low dose epinephrine (1.0uM) was associated with lower VTE risk (HR 0.84 [0.71–0.99]; p=0.042]. However, additional multivariable analyses attenuated the collagen-VTE and epinephrine-VTE associations to trends, primarily due to adjustment for baseline body mass index (BMI), a VTE risk factor and potential modifier of platelet function. Secondary analyses considering varying follow-up periods, cancer incidence and interim aspirin use did not dramatically affect the collagen and epinephrine trends observed. Baseline platelet aggregability was only weakly associated with incident VTE, and in a paradoxical direction, in a community-based population. Other markers of platelet function and hemostasis could prove to be more useful predictors.

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Section: Discussionmentioning

confidence: 99%

Platelet function as a risk factor for venous thromboembolism in the Framingham Heart Study

Puurunen

Hwang

O’Donnell

et al. 2017

Thrombosis Research

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“…The increased sensitivity of the radioisotope incorporation method may be due to the measurement of rates of thrombopoiesis as distinguished from measurements of the concentration of the circulating platelet pool. Furthermore, the newly formed younger platelets have been reported to be larger than older platelets (10,11). Therefore, we would expect a greater proportion of larger platelets in the recently stimulated animal, with a greater increase in total platelet mass than increase in number of circulating platelets.…”

Section: Channels Ratio Methodmentioning

confidence: 93%

“…1 mice (Carworth, Inc., New City, N.Y.) were used. Thrombopoietically active plasma was obtained from rats sacrificed [5][6][7][8][9][10][11][12][13][14][15][16][17][18] hr after injection of a rabbit antirat platelet serum (APS), which was prepared as described (1). The donors were bled from the abdominal aorta into siliconized syringes containing 0.15 vol of acid citrate dextrose solution, formula A (ACD) per vol of blood.…”

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confidence: 99%

Demonstration of a Circulating Factor Regulating Blood Platelet Production using 35S-Sulfate in Rats and Mice

Cooper¹,

Cooper²,

Chang³

1970

Experimental Biology and Medicine

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“…Circulating platelets are heterogeneous in size, density and activity [8,9]. Mean platelet volume (MPV), a measure of platelet size available in every blood count, is increasingly recognized as an important marker of platelet activity [10].…”

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confidence: 99%

Mean platelet volume and prevalence of peripheral artery disease, the National Health and Nutrition Examination Survey, 1999–2004

et al. 2010

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Objectives We sought to determine whether mean platelet volume (MPV) is associated with the prevalence of peripheral artery disease (PAD). Background Platelets play a pivotal role in the pathogenesis of atherosclerosis and PAD. MPV, a measure of platelet size available in every blood count, is increasingly recognized as an important marker of platelet activity. Methods We analyzed data from 6354 participants aged 40 years and older from the 1999 to 2004 National Health and Nutrition Examination Survey (NHANES), a nationally representative sample of the US population. PAD was defined as an ankle brachial index ≤0.90 in either leg. Odds ratios and 95% confidence intervals were estimated by logistic regression. Results The prevalence of PAD in the cohort was 5.7%. MPV was significantly associated with PAD prevalence (tertile 1 – 4.4%, tertile 2 – 6.1%, tertile 3 – 7.0%, P for trend = 0.003). After adjustment for age, sex, and race, the odds ratio of PAD comparing the highest tertile to the lowest tertile was 1.57 (95% confidence interval 1.15–2.13). After further adjustment for smoking status, hypertension, hypercholesterolemia, diabetes, glomerular filtration rate, body mass index, and platelet count the corresponding odds ratio was 1.58 (95% confidence interval 1.14–2.19). The addition of triglycerides, hemoglobin A1c, and C-reactive protein did not affect the results. The significant association between MPV and PAD was unchanged when MPV was used as a continuous variable. Conclusions Mean platelet volume is independently associated with PAD. These findings support the hypothesis that platelet size is an independent predictor of increased risk for PAD.

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Heterogeneity of human Platelets

Cited by 348 publications

References 24 publications

Platelet function as a risk factor for venous thromboembolism in the Framingham Heart Study

Platelet function as a risk factor for venous thromboembolism in the Framingham Heart Study

Demonstration of a Circulating Factor Regulating Blood Platelet Production using 35S-Sulfate in Rats and Mice

Mean platelet volume and prevalence of peripheral artery disease, the National Health and Nutrition Examination Survey, 1999–2004

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