Mean platelet volume and prevalence of peripheral artery disease, the National Health and Nutrition Examination Survey, 1999–2004

Abstract

Objectives We sought to determine whether mean platelet volume (MPV) is associated with the prevalence of peripheral artery disease (PAD). Background Platelets play a pivotal role in the pathogenesis of atherosclerosis and PAD. MPV, a measure of platelet size available in every blood count, is increasingly recognized as an important marker of platelet activity. Methods We analyzed data from 6354 participants aged 40 years and older from the 1999 to 2004 National Health and Nutrition Examination Survey (NHANES), a nationally representative sample of the US population. PAD was defined as an ankle brachial index ≤0.90 in either leg. Odds ratios and 95% confidence intervals were estimated by logistic regression. Results The prevalence of PAD in the cohort was 5.7%. MPV was significantly associated with PAD prevalence (tertile 1 – 4.4%, tertile 2 – 6.1%, tertile 3 – 7.0%, P for trend = 0.003). After adjustment for age, sex, and race, the odds ratio of PAD comparing the highest tertile to the lowest tertile was 1.57 (95% confidence interval 1.15–2.13). After further adjustment for smoking status, hypertension, hypercholesterolemia, diabetes, glomerular filtration rate, body mass index, and platelet count the corresponding odds ratio was 1.58 (95% confidence interval 1.14–2.19). The addition of triglycerides, hemoglobin A1c, and C-reactive protein did not affect the results. The significant association between MPV and PAD was unchanged when MPV was used as a continuous variable. Conclusions Mean platelet volume is independently associated with PAD. These findings support the hypothesis that platelet size is an independent predictor of increased risk for PAD.

MPV may reflect subcinical platelet activation in diabetic patients with and without diabetic retinopathy

“…12,13 Previous studies disclosed that MPV was linked with coronary artery disease, myocardial infarction, peripheral artery disease, and cerebral ischemia. [5][6][7][8] Several studies have showed that there were aggregates of thyrombocytes in retinal capillaries of diabetic rats. 14, 15 Tuzcu et al 9 conducted an experiment with 192 patients and showed a correlation between MPV levels and DR.…”

“…5 It is a marker indicating subclinical platelet activation and is an independent risk factor for various vascular episodes such as acute myocardial infarction, 5 coronary artery disease, 6 cerebral ischemia, 7 and peripheral artery disease. 8 There are limited reports in literature showing relation between DR and platelet indices. Increased MPV has been found to be associated with increased risk of retinopathy in diabetic patients.…”

The association between mean platelet volume levels and poststroke depression

“…As a meta‐analysis comprising 24 trials demonstrated, MPV is a positively associated with incidence of myocardial infarction as well as restenosis after coronary angioplasty (Chu et al, 2010). Meanwhile, high MPV levels had been found in patients with aortic arterial stiffness, peripheral artery disease (Balta et al, 2014; Berger, Eraso, Xie, Sha, & Mohler, 2010). Previous studies reported that high MPV levels were correlated with increased risk of ischemic stroke as well as unfavorable prognosis among survivors of stroke (Bath, Algert, Chapman, & Neal, 2004; Muscari et al, 2009).…”

Mean Platelet Volume: Is It a Predictive Parameter in Diagnosis of Acute Mesenteric Ischemia?

“…7 In patients with a myocardial infarction or cerebrovascular disease, [7][8][9][10][11][12] platelet volume has been found to be increased, and MPV is independently associated with peripheral artery disease. 13 However, data in mesenteric vascular disease are lacking. Our objective in this study is to discuss the usability of MPV, which is associated with numerous vascular pathologies, in the early diagnosis of AMI.…”